A study on the physiological disposition of acetophenetidin by the diabetic man
1. The rate of acetophenetidin metabolism after oral administration has been studied in normal and diabetic human subjects. 2. The rate of metabolism of the drug was slower in the diabetics, as judged by the larger quantities of unchanged compound as well as by the lower urinary levels of the de-eth...
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| Veröffentlicht in: | Comparative and general pharmacology 1974-01, Vol.5 (1), p.1-9 |
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| container_title | Comparative and general pharmacology |
| container_volume | 5 |
| creator | Dajani, R.M. Kayyali, S. Saheb, S.E. Birbari, A. |
| description | 1.
The rate of acetophenetidin metabolism after oral administration has been studied in normal and diabetic human subjects.
2.
The rate of metabolism of the drug was slower in the diabetics, as judged by the larger quantities of unchanged compound as well as by the lower urinary levels of the de-ethylated and conjugated derivatives excreted during identical intervals of time.
3.
Differences in the rate of excretion were more pronounced in patients with more severe diabetes.
4.
Treatment and stabilization of the diabetic state with insulin tended to revert the rate of metabolism of the drug to near normal values.
5.
Possible mechanisms for the altered pattern of the disposition of acetophenetidin are suggested. |
| doi_str_mv | 10.1016/S0306-3623(74)80003-0 |
| format | Article |
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The rate of acetophenetidin metabolism after oral administration has been studied in normal and diabetic human subjects.
2.
The rate of metabolism of the drug was slower in the diabetics, as judged by the larger quantities of unchanged compound as well as by the lower urinary levels of the de-ethylated and conjugated derivatives excreted during identical intervals of time.
3.
Differences in the rate of excretion were more pronounced in patients with more severe diabetes.
4.
Treatment and stabilization of the diabetic state with insulin tended to revert the rate of metabolism of the drug to near normal values.
5.
Possible mechanisms for the altered pattern of the disposition of acetophenetidin are suggested.</description><identifier>ISSN: 0010-4035</identifier><identifier>EISSN: 1878-2388</identifier><identifier>DOI: 10.1016/S0306-3623(74)80003-0</identifier><identifier>PMID: 4459026</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Acetophenetidin ; Administration, Oral ; Adult ; diabetes mellitus ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - metabolism ; drug metabolism ; Female ; glucuronide conjugates ; Humans ; insulin ; Insulin - pharmacology ; Insulin - therapeutic use ; Kinetics ; Male ; Middle Aged ; N-acetyl- p-aminophenol ; p-phenetidin ; phenacetin ; Phenacetin - administration & dosage ; Phenacetin - metabolism ; Phenacetin - urine ; Phenols - metabolism</subject><ispartof>Comparative and general pharmacology, 1974-01, Vol.5 (1), p.1-9</ispartof><rights>1974 Pergamon Press</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-b137900c5dd3ac491585fffb9c2f55b35f36d5c1ae35e8d6c15e9fc3e6bae79e3</citedby><cites>FETCH-LOGICAL-c360t-b137900c5dd3ac491585fffb9c2f55b35f36d5c1ae35e8d6c15e9fc3e6bae79e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4459026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dajani, R.M.</creatorcontrib><creatorcontrib>Kayyali, S.</creatorcontrib><creatorcontrib>Saheb, S.E.</creatorcontrib><creatorcontrib>Birbari, A.</creatorcontrib><title>A study on the physiological disposition of acetophenetidin by the diabetic man</title><title>Comparative and general pharmacology</title><addtitle>Comp Gen Pharmacol</addtitle><description>1.
The rate of acetophenetidin metabolism after oral administration has been studied in normal and diabetic human subjects.
2.
The rate of metabolism of the drug was slower in the diabetics, as judged by the larger quantities of unchanged compound as well as by the lower urinary levels of the de-ethylated and conjugated derivatives excreted during identical intervals of time.
3.
Differences in the rate of excretion were more pronounced in patients with more severe diabetes.
4.
Treatment and stabilization of the diabetic state with insulin tended to revert the rate of metabolism of the drug to near normal values.
5.
Possible mechanisms for the altered pattern of the disposition of acetophenetidin are suggested.</description><subject>Acetophenetidin</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - metabolism</subject><subject>drug metabolism</subject><subject>Female</subject><subject>glucuronide conjugates</subject><subject>Humans</subject><subject>insulin</subject><subject>Insulin - pharmacology</subject><subject>Insulin - therapeutic use</subject><subject>Kinetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>N-acetyl- p-aminophenol</subject><subject>p-phenetidin</subject><subject>phenacetin</subject><subject>Phenacetin - administration & dosage</subject><subject>Phenacetin - metabolism</subject><subject>Phenacetin - urine</subject><subject>Phenols - metabolism</subject><issn>0010-4035</issn><issn>1878-2388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EKqXwEyrlhOAQWMex45xQVfGSKvUAnC3HXlOjNA5xitR_T_oQV04r7czsaD9CphTuKFBx_wYMRMpExm6K_FYCAEvhhIypLGSaMSlPyRiAQpoD4-fkIsYvgGxI0hEZ5TkvIRNjspwlsd_YbRKapF9h0q620Yc6fHqj68T62Iboez-owSXaYB_aFTbYe-ubpNruM9bratiYZK2bS3LmdB3x6jgn5OPp8X3-ki6Wz6_z2SI1TECfVpQVJYDh1jJt8pJyyZ1zVWkyx3nFuGPCckM1Mo7SCkM5ls4wFJXGokQ2IdeHu20XvjcYe7X20WBd6wbDJiqZCUlLWgxGfjCaLsTYoVNt59e62yoKagdS7UGqHUhV5GoPUsGQmx4LNtUa7V_qSG7QHw46Dl_-eOxUNB4bg9Z3aHplg_-n4Rfn8IOF</recordid><startdate>19740101</startdate><enddate>19740101</enddate><creator>Dajani, R.M.</creator><creator>Kayyali, S.</creator><creator>Saheb, S.E.</creator><creator>Birbari, A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19740101</creationdate><title>A study on the physiological disposition of acetophenetidin by the diabetic man</title><author>Dajani, R.M. ; Kayyali, S. ; Saheb, S.E. ; Birbari, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-b137900c5dd3ac491585fffb9c2f55b35f36d5c1ae35e8d6c15e9fc3e6bae79e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Acetophenetidin</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - metabolism</topic><topic>drug metabolism</topic><topic>Female</topic><topic>glucuronide conjugates</topic><topic>Humans</topic><topic>insulin</topic><topic>Insulin - pharmacology</topic><topic>Insulin - therapeutic use</topic><topic>Kinetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>N-acetyl- p-aminophenol</topic><topic>p-phenetidin</topic><topic>phenacetin</topic><topic>Phenacetin - administration & dosage</topic><topic>Phenacetin - metabolism</topic><topic>Phenacetin - urine</topic><topic>Phenols - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Dajani, R.M.</creatorcontrib><creatorcontrib>Kayyali, S.</creatorcontrib><creatorcontrib>Saheb, S.E.</creatorcontrib><creatorcontrib>Birbari, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative and general pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dajani, R.M.</au><au>Kayyali, S.</au><au>Saheb, S.E.</au><au>Birbari, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study on the physiological disposition of acetophenetidin by the diabetic man</atitle><jtitle>Comparative and general pharmacology</jtitle><addtitle>Comp Gen Pharmacol</addtitle><date>1974-01-01</date><risdate>1974</risdate><volume>5</volume><issue>1</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0010-4035</issn><eissn>1878-2388</eissn><abstract>1.
The rate of acetophenetidin metabolism after oral administration has been studied in normal and diabetic human subjects.
2.
The rate of metabolism of the drug was slower in the diabetics, as judged by the larger quantities of unchanged compound as well as by the lower urinary levels of the de-ethylated and conjugated derivatives excreted during identical intervals of time.
3.
Differences in the rate of excretion were more pronounced in patients with more severe diabetes.
4.
Treatment and stabilization of the diabetic state with insulin tended to revert the rate of metabolism of the drug to near normal values.
5.
Possible mechanisms for the altered pattern of the disposition of acetophenetidin are suggested.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>4459026</pmid><doi>10.1016/S0306-3623(74)80003-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Comparative and general pharmacology, 1974-01, Vol.5 (1), p.1-9 |
| issn | 0010-4035 1878-2388 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acetophenetidin Administration, Oral Adult diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism drug metabolism Female glucuronide conjugates Humans insulin Insulin - pharmacology Insulin - therapeutic use Kinetics Male Middle Aged N-acetyl- p-aminophenol p-phenetidin phenacetin Phenacetin - administration & dosage Phenacetin - metabolism Phenacetin - urine Phenols - metabolism |
| title | A study on the physiological disposition of acetophenetidin by the diabetic man |
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