Friend leukemia: rapid development of erythropoietin-independent hematopoietic precursors

Infection of mice with the polycythemia-inducing strain of Friend leukemia virus caused a rapid emergence of new erythroid precursor cells. These cells which, in the absence of erythropoietin, proliferated in vitro to form colonies and even differnetiated, quickly out-numbered the usual erythropoiet...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1975-01, Vol.54 (1), p.265-267
Hauptverfasser:	Horoszewicz, J S, Leong, S S, Carter, W A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow - physiopathology Cell Division Erythropoiesis Erythropoietin - pharmacology Female Friend murine leukemia virus Leukemia, Erythroblastic, Acute - physiopathology Leukemia, Experimental - physiopathology Male Mice Spleen - physiopathology
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Beschreibung
Zusammenfassung:	Infection of mice with the polycythemia-inducing strain of Friend leukemia virus caused a rapid emergence of new erythroid precursor cells. These cells which, in the absence of erythropoietin, proliferated in vitro to form colonies and even differnetiated, quickly out-numbered the usual erythropoietin-dependent hematopoietic elements in bone marrow and spleen. Ultimately, the marrow and spleen were probably totally repopulated with this erythropoietin-independent cell.
ISSN:	0027-8874
DOI:	10.1093/jnci/54.1.265