Labilization of C—N Linkages by Dibenzocyclohepten-5-yl Ring System

The hydrolysis of several 5-aminodibenzo[a,d]cycloheptenes is discussed. The relative reactivity of the various compounds was closely related to the amino substituents at position 5 of the tricyclic nucleus. Both secondary and tertiary amines were prepared. They showed instability in aqueous solutio...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1974-12, Vol.63 (12), p.1908-1914
Hauptverfasser:	Maulding, H.V., Michaelis, A.F., Nazareno, J.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminodibenzo[a,d]cycloheptenes—hydrolysis rates, compared to cycloheptanes, effect of 5-amino substituents 5-Aminodibenzo]a Amines - chemical synthesis Chemical Phenomena Chemistry Chromatography, Thin Layer compared to cycloheptanes d[cycloheptenes d[cycloheptenes-hydrolysis rates d[cycloheptenes-hydrolysis rates compared to cycloheptanes Dibenzo[a,d]cycloheptenes—hydrolysis rates compared to cycloheptanes, effect of 5-amino substituents Dibenzo]a Dibenzocycloheptenes - chemical synthesis Drug Stability effect of 5-amino substituents Fluorenes Hydrogen-Ion Concentration Hydrolysis Hydrolysis-dibenzo]a Hydrolysis—dibenzo[a,d]cycloheptenes, effect of 5-amino substituents Kinetics Morpholines Oxidation-Reduction Solubility Spectrophotometry, Ultraviolet Temperature
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