Metabolic alterations after total body doses of X-radiation: I. The role of regenerating liver nuclei and cytoplasm in the inhibition due to X-radiation of incorporation of tritium-labeled thymidine into DNA
The effect of X-radiation on the incorporation of [ 3H]TDR into the DNA of nuclei of reconstituted regenerating liver homogenates and into purified DNA incubated with irradiated and non-irradiated regenerating liver cytoplasm was studied. The results indicate that both the nuclei and the cytoplasm a...
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| Veröffentlicht in: | Biochimica et biophysica acta 1960-12, Vol.45, p.57-62 |
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| container_title | Biochimica et biophysica acta |
| container_volume | 45 |
| creator | Van Lancker, Julien L. |
| description | The effect of X-radiation on the incorporation of [
3H]TDR into the DNA of nuclei of reconstituted regenerating liver homogenates and into purified DNA incubated with irradiated and non-irradiated regenerating liver cytoplasm was studied. The results indicate that both the nuclei and the cytoplasm are affected by X-radiation but the effect is more marked on the cytoplasm than on the nucleus. These findings suggest that X-radiation interferes with the activity of the enzymes involved in the incorporation of nucleosides or nucleotides into the DNA. |
| doi_str_mv | 10.1016/0006-3002(60)91424-4 |
| format | Article |
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3H]TDR into the DNA of nuclei of reconstituted regenerating liver homogenates and into purified DNA incubated with irradiated and non-irradiated regenerating liver cytoplasm was studied. The results indicate that both the nuclei and the cytoplasm are affected by X-radiation but the effect is more marked on the cytoplasm than on the nucleus. These findings suggest that X-radiation interferes with the activity of the enzymes involved in the incorporation of nucleosides or nucleotides into the DNA.</description><identifier>ISSN: 0006-3002</identifier><identifier>EISSN: 1878-2434</identifier><identifier>DOI: 10.1016/0006-3002(60)91424-4</identifier><identifier>PMID: 13780004</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cell Nucleus ; DNA - metabolism ; Liver - metabolism ; Liver Regeneration ; Nucleosides - metabolism ; Nucleotides - metabolism ; Old Medline ; Radiation Effects ; Thymidine ; Tritium ; X-Rays</subject><ispartof>Biochimica et biophysica acta, 1960-12, Vol.45, p.57-62</ispartof><rights>1960</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13780004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Lancker, Julien L.</creatorcontrib><title>Metabolic alterations after total body doses of X-radiation: I. The role of regenerating liver nuclei and cytoplasm in the inhibition due to X-radiation of incorporation of tritium-labeled thymidine into DNA</title><title>Biochimica et biophysica acta</title><addtitle>Biochim Biophys Acta</addtitle><description>The effect of X-radiation on the incorporation of [
3H]TDR into the DNA of nuclei of reconstituted regenerating liver homogenates and into purified DNA incubated with irradiated and non-irradiated regenerating liver cytoplasm was studied. The results indicate that both the nuclei and the cytoplasm are affected by X-radiation but the effect is more marked on the cytoplasm than on the nucleus. These findings suggest that X-radiation interferes with the activity of the enzymes involved in the incorporation of nucleosides or nucleotides into the DNA.</description><subject>Cell Nucleus</subject><subject>DNA - metabolism</subject><subject>Liver - metabolism</subject><subject>Liver Regeneration</subject><subject>Nucleosides - metabolism</subject><subject>Nucleotides - metabolism</subject><subject>Old Medline</subject><subject>Radiation Effects</subject><subject>Thymidine</subject><subject>Tritium</subject><subject>X-Rays</subject><issn>0006-3002</issn><issn>1878-2434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1960</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkd9uFSEQh4nR2GP1DYzhyujFtrCwLOuFSVP_NWn1pibeERZmWwwLp8A2OU_pK5U9rU2vZjLzzQfJD6G3lBxRQsUxIUQ0jJD2gyAfB8pb3vBnaENlL5uWM_4cbR6RA_Qq57-16RgZXqIDynpZl3yD_l1A0WP0zmDtCyRdXAwZ66n2uMSiPR6j3WEbM2QcJ_ynSdq6PfYJnx3hy2vAKXpYdwmuIOwd4Qp7d1sVYTEeHNbBYrMrcet1nrELuNQzF67d6FYTtgvU157KV58LJqZtTI-Dkiq-zI3XI3iw1bKbnXVhddXzLz9PXqMXk_YZ3jzUQ_T729fL0x_N-a_vZ6cn5w20fCiNGYWeRt11dhoo6RkTTMpJytF0gwBLJ0mpIJ3h3SB7beyowQpqJAzWTJMw7BC9v_duU7xZIBc1u2zAex0gLlnJVvC-JayC7x7AZZzBqm1ys0479T-CCny-B6B-99ZBUtk4CAasS2CKstEpStSauVoDVWugShC1z1xxdgf1p6IH</recordid><startdate>19601204</startdate><enddate>19601204</enddate><creator>Van Lancker, Julien L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19601204</creationdate><title>Metabolic alterations after total body doses of X-radiation: I. The role of regenerating liver nuclei and cytoplasm in the inhibition due to X-radiation of incorporation of tritium-labeled thymidine into DNA</title><author>Van Lancker, Julien L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e249t-cb6afba55df9107336388f88bc596ed1f811605c45987acdbaed61c8e9dcff6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1960</creationdate><topic>Cell Nucleus</topic><topic>DNA - metabolism</topic><topic>Liver - metabolism</topic><topic>Liver Regeneration</topic><topic>Nucleosides - metabolism</topic><topic>Nucleotides - metabolism</topic><topic>Old Medline</topic><topic>Radiation Effects</topic><topic>Thymidine</topic><topic>Tritium</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Lancker, Julien L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimica et biophysica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Lancker, Julien L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic alterations after total body doses of X-radiation: I. The role of regenerating liver nuclei and cytoplasm in the inhibition due to X-radiation of incorporation of tritium-labeled thymidine into DNA</atitle><jtitle>Biochimica et biophysica acta</jtitle><addtitle>Biochim Biophys Acta</addtitle><date>1960-12-04</date><risdate>1960</risdate><volume>45</volume><spage>57</spage><epage>62</epage><pages>57-62</pages><issn>0006-3002</issn><eissn>1878-2434</eissn><abstract>The effect of X-radiation on the incorporation of [
3H]TDR into the DNA of nuclei of reconstituted regenerating liver homogenates and into purified DNA incubated with irradiated and non-irradiated regenerating liver cytoplasm was studied. The results indicate that both the nuclei and the cytoplasm are affected by X-radiation but the effect is more marked on the cytoplasm than on the nucleus. These findings suggest that X-radiation interferes with the activity of the enzymes involved in the incorporation of nucleosides or nucleotides into the DNA.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>13780004</pmid><doi>10.1016/0006-3002(60)91424-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochimica et biophysica acta, 1960-12, Vol.45, p.57-62 |
| issn | 0006-3002 1878-2434 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82647203 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Cell Nucleus DNA - metabolism Liver - metabolism Liver Regeneration Nucleosides - metabolism Nucleotides - metabolism Old Medline Radiation Effects Thymidine Tritium X-Rays |
| title | Metabolic alterations after total body doses of X-radiation: I. The role of regenerating liver nuclei and cytoplasm in the inhibition due to X-radiation of incorporation of tritium-labeled thymidine into DNA |
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