High-Energy Bound Phosphate and Diabetes Mellitus

THE problem of whether oxidative phosphorylation is impaired in diabetes mellitus or not remains obscure. Cutolo and Siliprandi 1 and Sacks 2 demonstrated a decrease in high-energy bound phosphate content in alloxan-diabetic rat liver. Vester and Stadie 3 found diminished oxidative phosphorylation i...

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Veröffentlicht in:Nature (London) 1960-08, Vol.187 (4738), p.702-703
Hauptverfasser: GOTO, YOSHIO, ITO, ISAO, KUWANO, AKIHIKO, UJIIE, YUKIO
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container_issue 4738
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container_title Nature (London)
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creator GOTO, YOSHIO
ITO, ISAO
KUWANO, AKIHIKO
UJIIE, YUKIO
description THE problem of whether oxidative phosphorylation is impaired in diabetes mellitus or not remains obscure. Cutolo and Siliprandi 1 and Sacks 2 demonstrated a decrease in high-energy bound phosphate content in alloxan-diabetic rat liver. Vester and Stadie 3 found diminished oxidative phosphorylation in depancreatized cat liver mitochondria but not in alloxan-diabetic rat liver mitochondria. Parks et al. 4 also failed to find an abnormality in alloxan-diabetic rat liver mitochondria. Goranson and Erulkar 5 found uncoupling of oxidative phosphorylation in the heart muscle of alloxan-diabetic rats, but Peterson and his collaborators 6 reported that the high-energy bound phosphate content of skeletal muscle was in the normal range.
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subjects Diabetes Mellitus - metabolism
Humanities and Social Sciences
Humans
letter
multidisciplinary
Old Medline
Phosphates - metabolism
Science
Science (multidisciplinary)
title High-Energy Bound Phosphate and Diabetes Mellitus
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