The stapedius reflex in the diagnosis of myasthenia gravis
The contralateral stapedius reflex, elicited by a clearly-defined auditory stimulus, was studied in 3 patients with myasthenia gravis. The reflex was assessed by recording the change which occurred in the acoustic impedance of the middle ear. In all patients a decay (decrement) of the reflex was fou...
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| Veröffentlicht in: | Journal of the neurological sciences 1974, Vol.21 (1), p.71-76 |
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| container_title | Journal of the neurological sciences |
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| creator | Blom, S. Zakrisson, J.E. |
| description | The contralateral stapedius reflex, elicited by a clearly-defined auditory stimulus, was studied in 3 patients with myasthenia gravis. The reflex was assessed by recording the change which occurred in the acoustic impedance of the middle ear. In all patients a decay (decrement) of the reflex was found, interpreted as a sign of increased fatiguability at the neuromuscular junction of the stapedius muscle. The reflex recovered rapidly after the intravenous injection of a cholinesterase inhibitor (Tensilone̊g;).
It is concluded that the stapedius reflex test can be of value in the diagnosis of myasthenia gravis, since it can be well-standardized, involves a muscle innervated by the facial nerve and is not disturbing to the patient, whose active cooperation is not necessary. |
| doi_str_mv | 10.1016/0022-510X(74)90107-5 |
| format | Article |
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It is concluded that the stapedius reflex test can be of value in the diagnosis of myasthenia gravis, since it can be well-standardized, involves a muscle innervated by the facial nerve and is not disturbing to the patient, whose active cooperation is not necessary.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(74)90107-5</identifier><identifier>PMID: 4443816</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Adolescent ; Aged ; Ear, Middle ; Edrophonium ; Electromyography ; Female ; Humans ; Male ; Middle Aged ; Muscles - physiopathology ; Myasthenia Gravis - diagnosis ; Myasthenia Gravis - physiopathology ; Reflex</subject><ispartof>Journal of the neurological sciences, 1974, Vol.21 (1), p.71-76</ispartof><rights>1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-8a05ad3dce22f52d046c78e61412d0e108a444c85c98890dcd25734b7a72c3e63</citedby><cites>FETCH-LOGICAL-c357t-8a05ad3dce22f52d046c78e61412d0e108a444c85c98890dcd25734b7a72c3e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022510X74901075$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4443816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blom, S.</creatorcontrib><creatorcontrib>Zakrisson, J.E.</creatorcontrib><title>The stapedius reflex in the diagnosis of myasthenia gravis</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>The contralateral stapedius reflex, elicited by a clearly-defined auditory stimulus, was studied in 3 patients with myasthenia gravis. The reflex was assessed by recording the change which occurred in the acoustic impedance of the middle ear. In all patients a decay (decrement) of the reflex was found, interpreted as a sign of increased fatiguability at the neuromuscular junction of the stapedius muscle. The reflex recovered rapidly after the intravenous injection of a cholinesterase inhibitor (Tensilone̊g;).
It is concluded that the stapedius reflex test can be of value in the diagnosis of myasthenia gravis, since it can be well-standardized, involves a muscle innervated by the facial nerve and is not disturbing to the patient, whose active cooperation is not necessary.</description><subject>Acoustic Stimulation</subject><subject>Adolescent</subject><subject>Aged</subject><subject>Ear, Middle</subject><subject>Edrophonium</subject><subject>Electromyography</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscles - physiopathology</subject><subject>Myasthenia Gravis - diagnosis</subject><subject>Myasthenia Gravis - physiopathology</subject><subject>Reflex</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUJOoofVJJtsUg-CFL-g4KWCt5AmszWyHzXZLfbfm9rSo6dhZt6Zd-ZB6JySG0pocUsIY5mg5ONK8usxoURm4gANqZIqE0rlh2i4lxyjkxi_CCGFUuMBGnDOc0WLIbqbfQKOnVmC833EAcoKfrBvcJfqzptF00YfcVviem1iKjbe4EUwKx9P0VFpqghnuzhC70-Ps8lLNn17fp08TDObC9llyhBhXO4sMFYK5ggvrFRQUE5TApQok66xSthxuo0465iQOZ9LI5nNochH6HK7dxna7x5ip2sfLVSVaaDto1asYCxZJSHfCm1oY0yv6GXwtQlrTYneINMbHnrDQ0uu_5BpkcYudvv7eQ1uP7RjlPr32z6kJ1cego7WQ2MTsQC20671_xv8AlKKeec</recordid><startdate>1974</startdate><enddate>1974</enddate><creator>Blom, S.</creator><creator>Zakrisson, J.E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1974</creationdate><title>The stapedius reflex in the diagnosis of myasthenia gravis</title><author>Blom, S. ; Zakrisson, J.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-8a05ad3dce22f52d046c78e61412d0e108a444c85c98890dcd25734b7a72c3e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Acoustic Stimulation</topic><topic>Adolescent</topic><topic>Aged</topic><topic>Ear, Middle</topic><topic>Edrophonium</topic><topic>Electromyography</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscles - physiopathology</topic><topic>Myasthenia Gravis - diagnosis</topic><topic>Myasthenia Gravis - physiopathology</topic><topic>Reflex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blom, S.</creatorcontrib><creatorcontrib>Zakrisson, J.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blom, S.</au><au>Zakrisson, J.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The stapedius reflex in the diagnosis of myasthenia gravis</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1974</date><risdate>1974</risdate><volume>21</volume><issue>1</issue><spage>71</spage><epage>76</epage><pages>71-76</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>The contralateral stapedius reflex, elicited by a clearly-defined auditory stimulus, was studied in 3 patients with myasthenia gravis. The reflex was assessed by recording the change which occurred in the acoustic impedance of the middle ear. In all patients a decay (decrement) of the reflex was found, interpreted as a sign of increased fatiguability at the neuromuscular junction of the stapedius muscle. The reflex recovered rapidly after the intravenous injection of a cholinesterase inhibitor (Tensilone̊g;).
It is concluded that the stapedius reflex test can be of value in the diagnosis of myasthenia gravis, since it can be well-standardized, involves a muscle innervated by the facial nerve and is not disturbing to the patient, whose active cooperation is not necessary.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4443816</pmid><doi>10.1016/0022-510X(74)90107-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1974, Vol.21 (1), p.71-76 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acoustic Stimulation Adolescent Aged Ear, Middle Edrophonium Electromyography Female Humans Male Middle Aged Muscles - physiopathology Myasthenia Gravis - diagnosis Myasthenia Gravis - physiopathology Reflex |
| title | The stapedius reflex in the diagnosis of myasthenia gravis |
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