Aminopeptidases in the serum of pregnant and nonpregnant women
According to repeated gel permeation studies the serum of nonpregnant women contained one homogeneous enzyme peak acting on n-l-leucyl-2-naphthylamine. In late pregnancy the serum displayed an additional aminopeptidase fraction with a higher molecular weight than the enzyme(s) in the nonpregnancy sa...
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| Veröffentlicht in: | Biochemical medicine 1974-11, Vol.11 (3), p.210-216 |
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| container_title | Biochemical medicine |
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| creator | Mäkinen, Pirkko-Liisa Raekallio, Jyrki |
| description | According to repeated gel permeation studies the serum of nonpregnant women contained one homogeneous enzyme peak acting on
n-l-leucyl-2-naphthylamine. In late pregnancy the serum displayed an additional aminopeptidase fraction with a higher molecular weight than the enzyme(s) in the nonpregnancy samples. In isoelectric focusing, the enzyme activity of the pregnancy serum appeared as several heterogeneous peaks differing in their isoelectric points from those demonstrable in the nonpregnancy samples. Further, the aminopeptidases from both of the serum sources showed differences in their affector characteristics and substrate specificity. |
| doi_str_mv | 10.1016/0006-2944(74)90117-3 |
| format | Article |
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n-l-leucyl-2-naphthylamine. In late pregnancy the serum displayed an additional aminopeptidase fraction with a higher molecular weight than the enzyme(s) in the nonpregnancy samples. In isoelectric focusing, the enzyme activity of the pregnancy serum appeared as several heterogeneous peaks differing in their isoelectric points from those demonstrable in the nonpregnancy samples. Further, the aminopeptidases from both of the serum sources showed differences in their affector characteristics and substrate specificity.</description><identifier>ISSN: 0006-2944</identifier><identifier>EISSN: 1557-7996</identifier><identifier>DOI: 10.1016/0006-2944(74)90117-3</identifier><identifier>PMID: 4433345</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aminopeptidases - antagonists & inhibitors ; Aminopeptidases - blood ; Calcium - pharmacology ; Chromatography, Gel ; Cobalt - pharmacology ; Enzyme Activation - drug effects ; Female ; Humans ; Isoelectric Focusing ; Magnesium - pharmacology ; Naphthols ; Nickel - pharmacology ; Placenta - enzymology ; Pregnancy ; Pregnancy Trimester, Third ; Spectrophotometry ; Strontium - pharmacology ; Structure-Activity Relationship ; Zinc - pharmacology</subject><ispartof>Biochemical medicine, 1974-11, Vol.11 (3), p.210-216</ispartof><rights>1974</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-dc728d1e719ae8e4538e89ee9ce14b21e5b099106b03c43d3183ce51e9551d623</citedby><cites>FETCH-LOGICAL-c357t-dc728d1e719ae8e4538e89ee9ce14b21e5b099106b03c43d3183ce51e9551d623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4433345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mäkinen, Pirkko-Liisa</creatorcontrib><creatorcontrib>Raekallio, Jyrki</creatorcontrib><title>Aminopeptidases in the serum of pregnant and nonpregnant women</title><title>Biochemical medicine</title><addtitle>Biochem Med</addtitle><description>According to repeated gel permeation studies the serum of nonpregnant women contained one homogeneous enzyme peak acting on
n-l-leucyl-2-naphthylamine. In late pregnancy the serum displayed an additional aminopeptidase fraction with a higher molecular weight than the enzyme(s) in the nonpregnancy samples. In isoelectric focusing, the enzyme activity of the pregnancy serum appeared as several heterogeneous peaks differing in their isoelectric points from those demonstrable in the nonpregnancy samples. Further, the aminopeptidases from both of the serum sources showed differences in their affector characteristics and substrate specificity.</description><subject>Aminopeptidases - antagonists & inhibitors</subject><subject>Aminopeptidases - blood</subject><subject>Calcium - pharmacology</subject><subject>Chromatography, Gel</subject><subject>Cobalt - pharmacology</subject><subject>Enzyme Activation - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Isoelectric Focusing</subject><subject>Magnesium - pharmacology</subject><subject>Naphthols</subject><subject>Nickel - pharmacology</subject><subject>Placenta - enzymology</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third</subject><subject>Spectrophotometry</subject><subject>Strontium - pharmacology</subject><subject>Structure-Activity Relationship</subject><subject>Zinc - pharmacology</subject><issn>0006-2944</issn><issn>1557-7996</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcKeRA-rmU2y2VwKpfgFBS96DrvJVCPdZE22iv_eri09ehqG92OYh5BzoDdAobyllJZ5oTi_kvxaUQCZswMyBiFkLpUqD8l4bzkmJyl9UFpUnMOIjDhnjHExJtNZ63zosOudrROmzPmsf8csYVy3WVhmXcQ3X_s-q73NfPD7_Tu06E_J0bJeJTzbzQl5vb97mT_mi-eHp_lskRsmZJ9bI4vKAkpQNVbIBauwUojKIPCmABQNVQpo2VBmOLMMKmZQACohwJYFm5DLbW8Xw-caU69blwyuVrXHsE66KoSirBiMfGs0MaQUcam76No6_migesCmByZ6YKIl13_YNNvELnb966ZFuw_tOG306VbHzZNfDqNOxqE3aF1E02sb3P8HfgGdR3s5</recordid><startdate>197411</startdate><enddate>197411</enddate><creator>Mäkinen, Pirkko-Liisa</creator><creator>Raekallio, Jyrki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197411</creationdate><title>Aminopeptidases in the serum of pregnant and nonpregnant women</title><author>Mäkinen, Pirkko-Liisa ; Raekallio, Jyrki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-dc728d1e719ae8e4538e89ee9ce14b21e5b099106b03c43d3183ce51e9551d623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Aminopeptidases - antagonists & inhibitors</topic><topic>Aminopeptidases - blood</topic><topic>Calcium - pharmacology</topic><topic>Chromatography, Gel</topic><topic>Cobalt - pharmacology</topic><topic>Enzyme Activation - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Isoelectric Focusing</topic><topic>Magnesium - pharmacology</topic><topic>Naphthols</topic><topic>Nickel - pharmacology</topic><topic>Placenta - enzymology</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Third</topic><topic>Spectrophotometry</topic><topic>Strontium - pharmacology</topic><topic>Structure-Activity Relationship</topic><topic>Zinc - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Mäkinen, Pirkko-Liisa</creatorcontrib><creatorcontrib>Raekallio, Jyrki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mäkinen, Pirkko-Liisa</au><au>Raekallio, Jyrki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aminopeptidases in the serum of pregnant and nonpregnant women</atitle><jtitle>Biochemical medicine</jtitle><addtitle>Biochem Med</addtitle><date>1974-11</date><risdate>1974</risdate><volume>11</volume><issue>3</issue><spage>210</spage><epage>216</epage><pages>210-216</pages><issn>0006-2944</issn><eissn>1557-7996</eissn><abstract>According to repeated gel permeation studies the serum of nonpregnant women contained one homogeneous enzyme peak acting on
n-l-leucyl-2-naphthylamine. In late pregnancy the serum displayed an additional aminopeptidase fraction with a higher molecular weight than the enzyme(s) in the nonpregnancy samples. In isoelectric focusing, the enzyme activity of the pregnancy serum appeared as several heterogeneous peaks differing in their isoelectric points from those demonstrable in the nonpregnancy samples. Further, the aminopeptidases from both of the serum sources showed differences in their affector characteristics and substrate specificity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4433345</pmid><doi>10.1016/0006-2944(74)90117-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2944 |
| ispartof | Biochemical medicine, 1974-11, Vol.11 (3), p.210-216 |
| issn | 0006-2944 1557-7996 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aminopeptidases - antagonists & inhibitors Aminopeptidases - blood Calcium - pharmacology Chromatography, Gel Cobalt - pharmacology Enzyme Activation - drug effects Female Humans Isoelectric Focusing Magnesium - pharmacology Naphthols Nickel - pharmacology Placenta - enzymology Pregnancy Pregnancy Trimester, Third Spectrophotometry Strontium - pharmacology Structure-Activity Relationship Zinc - pharmacology |
| title | Aminopeptidases in the serum of pregnant and nonpregnant women |
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