Vascular invasion and hematogenous dissemination of Hodgkin's disease
The clinical records and pathologic material of 125 Hodgkin's disease patients consecutively admitted to the Baltimore Cancer Research Center for staging laparotomy were reviewed. Diagnostic lymph node biopsies from 91 of these patients studied for evidence of vascular invasion revealed 4 biops...
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| Veröffentlicht in: | Cancer 1974-10, Vol.34 (4), p.1159-1162 |
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| container_title | Cancer |
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| creator | Kirschner, Robert H. Abt, Arthur B. O'Connell, Michael J. Sklansky, B. Donald Greene, William H. Wiernik, Peter H. |
| description | The clinical records and pathologic material of 125 Hodgkin's disease patients consecutively admitted to the Baltimore Cancer Research Center for staging laparotomy were reviewed. Diagnostic lymph node biopsies from 91 of these patients studied for evidence of vascular invasion revealed 4 biopsies that were positive (4.4%). The course of the disease in these patients has not been distinguished by extranodal dissemination or shortened survival. In contrast, vascular invasion in the spleen, present in 7 of 44 spleens involved by Hodgkin's disease (16%), was associated with hepatic and bone marrow metastases, early relapse, and shortened survival. The results indicate that while vascular invasion in diagnostic lymph node biopsies may not have prognostic implications, the presence of vascular invasion in the spleen is an ominous sign. |
| doi_str_mv | 10.1002/1097-0142(197410)34:4<1159::AID-CNCR2820340427>3.0.CO;2-Z |
| format | Article |
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Donald ; Greene, William H. ; Wiernik, Peter H.</creator><creatorcontrib>Kirschner, Robert H. ; Abt, Arthur B. ; O'Connell, Michael J. ; Sklansky, B. Donald ; Greene, William H. ; Wiernik, Peter H.</creatorcontrib><description>The clinical records and pathologic material of 125 Hodgkin's disease patients consecutively admitted to the Baltimore Cancer Research Center for staging laparotomy were reviewed. Diagnostic lymph node biopsies from 91 of these patients studied for evidence of vascular invasion revealed 4 biopsies that were positive (4.4%). The course of the disease in these patients has not been distinguished by extranodal dissemination or shortened survival. In contrast, vascular invasion in the spleen, present in 7 of 44 spleens involved by Hodgkin's disease (16%), was associated with hepatic and bone marrow metastases, early relapse, and shortened survival. The results indicate that while vascular invasion in diagnostic lymph node biopsies may not have prognostic implications, the presence of vascular invasion in the spleen is an ominous sign.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(197410)34:4<1159::AID-CNCR2820340427>3.0.CO;2-Z</identifier><identifier>PMID: 4425084</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Biopsy ; Blood Vessels - pathology ; Bone Marrow Diseases ; Child ; Female ; Hodgkin Disease - pathology ; Humans ; Liver Neoplasms ; Lymph Nodes - pathology ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Spleen - pathology</subject><ispartof>Cancer, 1974-10, Vol.34 (4), p.1159-1162</ispartof><rights>Copyright © 1974 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4637-4eb165cb6a4fc799b5ea5a1944c2a8ed721249a0d70f3f8bdf2e6a5c8cf00fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4425084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirschner, Robert H.</creatorcontrib><creatorcontrib>Abt, Arthur B.</creatorcontrib><creatorcontrib>O'Connell, Michael J.</creatorcontrib><creatorcontrib>Sklansky, B. 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The results indicate that while vascular invasion in diagnostic lymph node biopsies may not have prognostic implications, the presence of vascular invasion in the spleen is an ominous sign.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biopsy</subject><subject>Blood Vessels - pathology</subject><subject>Bone Marrow Diseases</subject><subject>Child</subject><subject>Female</subject><subject>Hodgkin Disease - pathology</subject><subject>Humans</subject><subject>Liver Neoplasms</subject><subject>Lymph Nodes - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Prognosis</subject><subject>Spleen - pathology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFtrFEEQRhtR4hr9CcI8eXmYtbq7enp6FWEZowkEFySI5qXo6UscnUuc3lXy751xl4A-CD4Vxan6qjiMrTksOYB4wcHoHDiKZ9xo5PBc4gpfca7MarU-e5NX76sPohQgEVDo13IJy2rzUuSXd9jidvcuWwBAmSuUn-6zByl9nVotlDxiR4hCQYkLdvLRJrdr7Zg1_Q-bmqHPbO-zL6Gz2-Eq9MMuZb5JKXRNb7czHmJ2Ovirb03_9DcKNoWH7F60bQqPDvWYXbw9uahO8_PNu7NqfZ47LKTOMdS8UK4uLEanjalVsMpyg-iELYPXggs0FryGKGNZ-yhCYZUrXQSIXh6zJ_vY63H4vgtpS12TXGhb24fpUSqFKrUpzDT4eT_oxiGlMUS6HpvOjjfEgWbDNFui2RLtDZNEQpoNE02G6U_DJAmo2pCgyyn78eGJXd0Ff5t8UDpxv-c_mzbc_M_hf979i8hfR96ZQA</recordid><startdate>197410</startdate><enddate>197410</enddate><creator>Kirschner, Robert H.</creator><creator>Abt, Arthur B.</creator><creator>O'Connell, Michael J.</creator><creator>Sklansky, B. 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Donald ; Greene, William H. ; Wiernik, Peter H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4637-4eb165cb6a4fc799b5ea5a1944c2a8ed721249a0d70f3f8bdf2e6a5c8cf00fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biopsy</topic><topic>Blood Vessels - pathology</topic><topic>Bone Marrow Diseases</topic><topic>Child</topic><topic>Female</topic><topic>Hodgkin Disease - pathology</topic><topic>Humans</topic><topic>Liver Neoplasms</topic><topic>Lymph Nodes - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Prognosis</topic><topic>Spleen - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirschner, Robert H.</creatorcontrib><creatorcontrib>Abt, Arthur B.</creatorcontrib><creatorcontrib>O'Connell, Michael J.</creatorcontrib><creatorcontrib>Sklansky, B. Donald</creatorcontrib><creatorcontrib>Greene, William H.</creatorcontrib><creatorcontrib>Wiernik, Peter H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirschner, Robert H.</au><au>Abt, Arthur B.</au><au>O'Connell, Michael J.</au><au>Sklansky, B. Donald</au><au>Greene, William H.</au><au>Wiernik, Peter H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular invasion and hematogenous dissemination of Hodgkin's disease</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1974-10</date><risdate>1974</risdate><volume>34</volume><issue>4</issue><spage>1159</spage><epage>1162</epage><pages>1159-1162</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>The clinical records and pathologic material of 125 Hodgkin's disease patients consecutively admitted to the Baltimore Cancer Research Center for staging laparotomy were reviewed. Diagnostic lymph node biopsies from 91 of these patients studied for evidence of vascular invasion revealed 4 biopsies that were positive (4.4%). The course of the disease in these patients has not been distinguished by extranodal dissemination or shortened survival. In contrast, vascular invasion in the spleen, present in 7 of 44 spleens involved by Hodgkin's disease (16%), was associated with hepatic and bone marrow metastases, early relapse, and shortened survival. The results indicate that while vascular invasion in diagnostic lymph node biopsies may not have prognostic implications, the presence of vascular invasion in the spleen is an ominous sign.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4425084</pmid><doi>10.1002/1097-0142(197410)34:4<1159::AID-CNCR2820340427>3.0.CO;2-Z</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 1974-10, Vol.34 (4), p.1159-1162 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biopsy Blood Vessels - pathology Bone Marrow Diseases Child Female Hodgkin Disease - pathology Humans Liver Neoplasms Lymph Nodes - pathology Male Middle Aged Neoplasm Metastasis Prognosis Spleen - pathology |
| title | Vascular invasion and hematogenous dissemination of Hodgkin's disease |
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