Ceramide biosynthesis in mouse brain microsomes: Comparison between C57/BL controls and quaking mutants

The biosynthesis of ceramides by mouse brain microsomes from sphingosine and stearoyl or lignoceroyl CoA was investigated. Microsomes from Quaking and normal mice showed similar activities when the acyl donor was stearate, but the Quaking mice exhibited about 55% less activity than normals when the...

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Veröffentlicht in:	Brain research 1974-12, Vol.81 (3), p.511-518
Hauptverfasser:	Zalc, Bernard, Pollet, Serge A., Harpin, Marie-Luce, Baumann, Nicole A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain - ultrastructure Brain Chemistry Ceramides - biosynthesis Coenzyme A - metabolism Fatty Acids - analysis Female Galactose - analysis Glucose - analysis Male Mice - metabolism Mice, Inbred C57BL Microsomes - metabolism Mutation Seizures - metabolism Sphingolipids - biosynthesis Sphingosine - analogs & derivatives Sphingosine - analysis Stearic Acids - metabolism Time Factors
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