Release of a Water-Soluble Drug from a Wax Matrix Timed-Release Tablet
The purpose of this work was to characterize the release of drug from a wax matrix tablet under relatively mild agitation conditions. It was found that phenylpropanolamine hydrochloride was released from a typical wax matrix by a diffusion mechanism. After an initial rapid release of drug from the t...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1974-11, Vol.63 (11), p.1748-1751 |
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| Hauptverfasser: | , , |
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| container_end_page | 1751 |
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| container_issue | 11 |
| container_start_page | 1748 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 63 |
| creator | Goodhart, Frank W. McCoy, Robert H. Ninger, Fred C. |
| description | The purpose of this work was to characterize the release of drug from a wax matrix tablet under relatively mild agitation conditions. It was found that phenylpropanolamine hydrochloride was released from a typical wax matrix by a diffusion mechanism. After an initial rapid release of drug from the tablet, the amount dissolved was proportional to the square root of time. The advance of the solvent front into the tablet matrix was also proportional to the square root of time. Compression force was not a major factor affecting drug release. Data on drug release from a single tablet face compared to release from a totally exposed tablet indicated that drug release is proportional to the total surface area. |
| doi_str_mv | 10.1002/jps.2600631117 |
| format | Article |
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It was found that phenylpropanolamine hydrochloride was released from a typical wax matrix by a diffusion mechanism. After an initial rapid release of drug from the tablet, the amount dissolved was proportional to the square root of time. The advance of the solvent front into the tablet matrix was also proportional to the square root of time. Compression force was not a major factor affecting drug release. 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Pharm. Sci</addtitle><description>The purpose of this work was to characterize the release of drug from a wax matrix tablet under relatively mild agitation conditions. It was found that phenylpropanolamine hydrochloride was released from a typical wax matrix by a diffusion mechanism. After an initial rapid release of drug from the tablet, the amount dissolved was proportional to the square root of time. The advance of the solvent front into the tablet matrix was also proportional to the square root of time. Compression force was not a major factor affecting drug release. Data on drug release from a single tablet face compared to release from a totally exposed tablet indicated that drug release is proportional to the total surface area.</description><subject>Calcium</subject><subject>Colloids</subject><subject>Delayed-Action Preparations</subject><subject>Diffusion</subject><subject>Drug release-phenylpropanolamine hydrochloride release rate from wax matrix timed-release tablet</subject><subject>Kinetics</subject><subject>mechanisms</subject><subject>mild agitation conditions</subject><subject>Phenylpropanolamine</subject><subject>Phenylpropanolamine hydrochloride-release rate from wax matrix timed-release tablet</subject><subject>Phenylpropanolamine hydrochloride— release rate from wax matrix timed-release tablet, mechanisms</subject><subject>Pressure</subject><subject>Solubility</subject><subject>Surface Properties</subject><subject>Tablets</subject><subject>Time Factors</subject><subject>Timed-release tablets</subject><subject>Timed-release tablets, wax matrix—water-soluble drug release (phenylpropanolamine hydrochloride), mild agitation conditions, mechanisms</subject><subject>Wax matrix (timed-release tablet)-release rate of phenylpropanolamine hydrochloride</subject><subject>Wax matrix (timed-release tablet)—release rate of phenylpropanolamine hydrochloride, mechanisms</subject><subject>wax matrix-water-soluble drug release (phenylpropanolamine hydrochloride)</subject><subject>Waxes</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9P2zAUx60JVLpuV25IOXFLeU78Iz5OZe02CkyjUxEXy0lekFlKOjvZyn-PSwrTDoiDZVnfz_f7_L6EHFIYU4Dk5G7tx4kAECmlVL4jQ8oTiAVQuUeGAUjilDN1QN57fwcBA84HZMBYIpNUDMn0B9ZoPEZNFZloaVp08VVTd3mN0anrbqPKNasnZROdm9bZTbSwKyzjZ9_CBLT9QPYrU3v8uLtH5Of082LyJZ5fzr5OPs3jIgyUMaYAiufhSEWNMgqUEpQqiYIhsFIB40yokrLw0yrLVcaVASi2b1oISEfkuM9du-Z3h77VK-sLrGtzj03ndZZwCYrRAI57sHCN9w4rvXZ2ZdyDpqC3xelQnP5XXDAc7ZK7POz3gu-aCrrq9b-2xoc30vS371f_Zce91_oWNy9e435pIVPJ9fJipic3i_n1Us70WeCznsdQ5R-LTvvC4n2BpXVYtLps7GtrPAKG_JfR</recordid><startdate>197411</startdate><enddate>197411</enddate><creator>Goodhart, Frank W.</creator><creator>McCoy, Robert H.</creator><creator>Ninger, Fred C.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197411</creationdate><title>Release of a Water-Soluble Drug from a Wax Matrix Timed-Release Tablet</title><author>Goodhart, Frank W. ; McCoy, Robert H. ; Ninger, Fred C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4277-e30095b095791a9a909961197e64e04d9045469d14006f8b9859a00c14001c603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Calcium</topic><topic>Colloids</topic><topic>Delayed-Action Preparations</topic><topic>Diffusion</topic><topic>Drug release-phenylpropanolamine hydrochloride release rate from wax matrix timed-release tablet</topic><topic>Kinetics</topic><topic>mechanisms</topic><topic>mild agitation conditions</topic><topic>Phenylpropanolamine</topic><topic>Phenylpropanolamine hydrochloride-release rate from wax matrix timed-release tablet</topic><topic>Phenylpropanolamine hydrochloride— release rate from wax matrix timed-release tablet, mechanisms</topic><topic>Pressure</topic><topic>Solubility</topic><topic>Surface Properties</topic><topic>Tablets</topic><topic>Time Factors</topic><topic>Timed-release tablets</topic><topic>Timed-release tablets, wax matrix—water-soluble drug release (phenylpropanolamine hydrochloride), mild agitation conditions, mechanisms</topic><topic>Wax matrix (timed-release tablet)-release rate of phenylpropanolamine hydrochloride</topic><topic>Wax matrix (timed-release tablet)—release rate of phenylpropanolamine hydrochloride, mechanisms</topic><topic>wax matrix-water-soluble drug release (phenylpropanolamine hydrochloride)</topic><topic>Waxes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goodhart, Frank W.</creatorcontrib><creatorcontrib>McCoy, Robert H.</creatorcontrib><creatorcontrib>Ninger, Fred C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goodhart, Frank W.</au><au>McCoy, Robert H.</au><au>Ninger, Fred C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Release of a Water-Soluble Drug from a Wax Matrix Timed-Release Tablet</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1974-11</date><risdate>1974</risdate><volume>63</volume><issue>11</issue><spage>1748</spage><epage>1751</epage><pages>1748-1751</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The purpose of this work was to characterize the release of drug from a wax matrix tablet under relatively mild agitation conditions. It was found that phenylpropanolamine hydrochloride was released from a typical wax matrix by a diffusion mechanism. After an initial rapid release of drug from the tablet, the amount dissolved was proportional to the square root of time. The advance of the solvent front into the tablet matrix was also proportional to the square root of time. Compression force was not a major factor affecting drug release. Data on drug release from a single tablet face compared to release from a totally exposed tablet indicated that drug release is proportional to the total surface area.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>4427236</pmid><doi>10.1002/jps.2600631117</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1974-11, Vol.63 (11), p.1748-1751 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82570941 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Calcium Colloids Delayed-Action Preparations Diffusion Drug release-phenylpropanolamine hydrochloride release rate from wax matrix timed-release tablet Kinetics mechanisms mild agitation conditions Phenylpropanolamine Phenylpropanolamine hydrochloride-release rate from wax matrix timed-release tablet Phenylpropanolamine hydrochloride— release rate from wax matrix timed-release tablet, mechanisms Pressure Solubility Surface Properties Tablets Time Factors Timed-release tablets Timed-release tablets, wax matrix—water-soluble drug release (phenylpropanolamine hydrochloride), mild agitation conditions, mechanisms Wax matrix (timed-release tablet)-release rate of phenylpropanolamine hydrochloride Wax matrix (timed-release tablet)—release rate of phenylpropanolamine hydrochloride, mechanisms wax matrix-water-soluble drug release (phenylpropanolamine hydrochloride) Waxes |
| title | Release of a Water-Soluble Drug from a Wax Matrix Timed-Release Tablet |
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