Homovanillic acid: Entry rate kinetics for transfer from plasma to cerebrospinal fluid

Because some studies have indicated that 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid [HVA]) does not cross the blood-CSF barrier, it is assumed by some that CSF HVA levels, after L-DOPA administration, validly reflect central nervous system (CNS) metabolism of dopamine. These experiments...

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Veröffentlicht in:	Brain research 1974-11, Vol.80 (3), p.435-442
Hauptverfasser:	Prockop, Leon, Fahn, Stanley, Barbour, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Blood-Brain Barrier Carbon Radioisotopes Dogs Homovanillic Acid - blood Homovanillic Acid - cerebrospinal fluid Homovanillic Acid - metabolism Injections, Intravenous Kinetics Levodopa - administration & dosage Levodopa - metabolism Mannitol - metabolism Phenylacetates - metabolism
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