$DDT increases the aminoacyl-tRNA binding activity of liver pH 5 supernatant fraction$

DDT increases the aminoacyl-tRNA binding activity of liver pH 5 supernatant fraction

The incorporation of [ 14C]phenylalanyl-tRNA into peptide was measured in cell-free preparations obtained from the liver of control rats and the liver of rats that had received DDT. Elongation factors 1 (EF 1) and 2 (EF 2), necessary for the binding of aminoacyl-tRNA to ribosomes and for the translo...

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Veröffentlicht in:	Chemico-biological interactions 1974-01, Vol.9 (3), p.155-168
Hauptverfasser:	Cappon, I.D., Nicholls, D.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acyl-tRNA Synthetases - metabolism Animals Carbon Radioisotopes Cell Fractionation Chromatography, Gel Cytosol - metabolism DDT - pharmacology Dose-Response Relationship, Drug Hydrogen-Ion Concentration Liver - drug effects Liver - metabolism Male Microsomes, Liver - metabolism Peptide Chain Elongation, Translational - drug effects Peptide Elongation Factors Phenylalanine Rats Receptors, Drug - drug effects Ribonucleases - metabolism Ribosomes - metabolism RNA, Transfer - metabolism Subcellular Fractions - drug effects Subcellular Fractions - metabolism Time Factors Transfer RNA Aminoacylation - drug effects Ultracentrifugation
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