A fluorometrical study on the reaction of rat synaptic membranes with cholinergic drugs
The response of synaptic membranes(SM) derived from the cerebral cortex of rats to the cholinergic drugs, acetylcholine(ACh) and acetylthiocholine(ATCh), was observed by the mehtod of fluorometry with 1-anilinonaphthalene-8-sulfonate sodium salt(ANS). The effects of atropine and hexamethonium on the...
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| Veröffentlicht in: | Pharmacological research communications 1974-08, Vol.6 (4), p.363-368 |
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| container_end_page | 368 |
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| container_title | Pharmacological research communications |
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| creator | Sekiya, M. Kikuno, M. |
| description | The response of synaptic membranes(SM) derived from the cerebral cortex of rats to the cholinergic drugs, acetylcholine(ACh) and acetylthiocholine(ATCh), was observed by the mehtod of fluorometry with 1-anilinonaphthalene-8-sulfonate sodium salt(ANS).
The effects of atropine and hexamethonium on the SM-ANS complex and the differences in responsiveness of SM to each of the drugs were observed.
Ca
2+ions were supposed to have a certain role in the cholinergic reaction of ACh at the SM. |
| doi_str_mv | 10.1016/S0031-6989(74)80036-6 |
| format | Article |
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The effects of atropine and hexamethonium on the SM-ANS complex and the differences in responsiveness of SM to each of the drugs were observed.
Ca
2+ions were supposed to have a certain role in the cholinergic reaction of ACh at the SM.</description><identifier>ISSN: 0031-6989</identifier><identifier>EISSN: 1879-2936</identifier><identifier>DOI: 10.1016/S0031-6989(74)80036-6</identifier><identifier>PMID: 4438403</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>Acetylcholine - analogs & derivatives ; Acetylcholine - pharmacology ; Anilino Naphthalenesulfonates ; Animals ; Atropine - pharmacology ; Calcium - pharmacology ; Cerebral Cortex - ultrastructure ; Hexamethonium Compounds - pharmacology ; In Vitro Techniques ; Nerve Tissue Proteins - analysis ; Parasympathomimetics - pharmacology ; Physostigmine - pharmacology ; Rats ; Spectrometry, Fluorescence ; Synaptic Membranes - analysis ; Synaptic Membranes - drug effects</subject><ispartof>Pharmacological research communications, 1974-08, Vol.6 (4), p.363-368</ispartof><rights>1974 The Italian Phannacological Society</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-14125fed886d229d5f5574988c71787708406f76c8ad255a5b2c1d1dd296992d3</citedby><cites>FETCH-LOGICAL-c360t-14125fed886d229d5f5574988c71787708406f76c8ad255a5b2c1d1dd296992d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4438403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sekiya, M.</creatorcontrib><creatorcontrib>Kikuno, M.</creatorcontrib><title>A fluorometrical study on the reaction of rat synaptic membranes with cholinergic drugs</title><title>Pharmacological research communications</title><addtitle>Pharmacol Res Commun</addtitle><description>The response of synaptic membranes(SM) derived from the cerebral cortex of rats to the cholinergic drugs, acetylcholine(ACh) and acetylthiocholine(ATCh), was observed by the mehtod of fluorometry with 1-anilinonaphthalene-8-sulfonate sodium salt(ANS).
The effects of atropine and hexamethonium on the SM-ANS complex and the differences in responsiveness of SM to each of the drugs were observed.
Ca
2+ions were supposed to have a certain role in the cholinergic reaction of ACh at the SM.</description><subject>Acetylcholine - analogs & derivatives</subject><subject>Acetylcholine - pharmacology</subject><subject>Anilino Naphthalenesulfonates</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Calcium - pharmacology</subject><subject>Cerebral Cortex - ultrastructure</subject><subject>Hexamethonium Compounds - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Nerve Tissue Proteins - analysis</subject><subject>Parasympathomimetics - pharmacology</subject><subject>Physostigmine - pharmacology</subject><subject>Rats</subject><subject>Spectrometry, Fluorescence</subject><subject>Synaptic Membranes - analysis</subject><subject>Synaptic Membranes - drug effects</subject><issn>0031-6989</issn><issn>1879-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEUha2qiIa0PwHJq4ouptie8WuFUNSWSkgsAHVpOfYd4mpmnNoeUP49DonYdnV1dM59fQidU_KdEiou7wlpaSO00hey-6aqEo34gBZUSd0w3YqPaPEe-YTOcv5bJROUnKLTrmtVR9oF-nON-2GOKY5QUnB2wLnMfofjhMsGcALrSqgi9jjZgvNustsSHB5hXCc7QcYvoWyw28QhTJCequXT_JQ_o5PeDhm-HOsSPf788bC6aW7vfv1eXd82rhWkNLSjjPfglRKeMe15z7nstFJOUqmkJPVK0UvhlPWMc8vXzFFPvWdaaM18u0RfD3O3Kf6bIRczhuxgGOptcc5GMc4EaXUN8kPQpZhzgt5sUxht2hlKzB6oeQNq9rSM7MwbUCNq3_lxwbwewb93HQlW_-rgQ_3yOUAy2QWYHPiQwBXjY_jPhlfLIIUu</recordid><startdate>197408</startdate><enddate>197408</enddate><creator>Sekiya, M.</creator><creator>Kikuno, M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197408</creationdate><title>A fluorometrical study on the reaction of rat synaptic membranes with cholinergic drugs</title><author>Sekiya, M. ; Kikuno, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-14125fed886d229d5f5574988c71787708406f76c8ad255a5b2c1d1dd296992d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Acetylcholine - analogs & derivatives</topic><topic>Acetylcholine - pharmacology</topic><topic>Anilino Naphthalenesulfonates</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Calcium - pharmacology</topic><topic>Cerebral Cortex - ultrastructure</topic><topic>Hexamethonium Compounds - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Nerve Tissue Proteins - analysis</topic><topic>Parasympathomimetics - pharmacology</topic><topic>Physostigmine - pharmacology</topic><topic>Rats</topic><topic>Spectrometry, Fluorescence</topic><topic>Synaptic Membranes - analysis</topic><topic>Synaptic Membranes - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Sekiya, M.</creatorcontrib><creatorcontrib>Kikuno, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sekiya, M.</au><au>Kikuno, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A fluorometrical study on the reaction of rat synaptic membranes with cholinergic drugs</atitle><jtitle>Pharmacological research communications</jtitle><addtitle>Pharmacol Res Commun</addtitle><date>1974-08</date><risdate>1974</risdate><volume>6</volume><issue>4</issue><spage>363</spage><epage>368</epage><pages>363-368</pages><issn>0031-6989</issn><eissn>1879-2936</eissn><abstract>The response of synaptic membranes(SM) derived from the cerebral cortex of rats to the cholinergic drugs, acetylcholine(ACh) and acetylthiocholine(ATCh), was observed by the mehtod of fluorometry with 1-anilinonaphthalene-8-sulfonate sodium salt(ANS).
The effects of atropine and hexamethonium on the SM-ANS complex and the differences in responsiveness of SM to each of the drugs were observed.
Ca
2+ions were supposed to have a certain role in the cholinergic reaction of ACh at the SM.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>4438403</pmid><doi>10.1016/S0031-6989(74)80036-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6989 |
| ispartof | Pharmacological research communications, 1974-08, Vol.6 (4), p.363-368 |
| issn | 0031-6989 1879-2936 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acetylcholine - analogs & derivatives Acetylcholine - pharmacology Anilino Naphthalenesulfonates Animals Atropine - pharmacology Calcium - pharmacology Cerebral Cortex - ultrastructure Hexamethonium Compounds - pharmacology In Vitro Techniques Nerve Tissue Proteins - analysis Parasympathomimetics - pharmacology Physostigmine - pharmacology Rats Spectrometry, Fluorescence Synaptic Membranes - analysis Synaptic Membranes - drug effects |
| title | A fluorometrical study on the reaction of rat synaptic membranes with cholinergic drugs |
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