Methylmercury is a potent inhibitor of membrane adenyl cyclase
THE toxicity of methylmercury has taken on added importance since it was discovered that inorganic mercury can be converted to methylmercury by bacteria in bottom sediments of lakes and homogenates of rotting fish 1,2 . The mechanism for methylation of inorganic mercury by bacteria has been describe...
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| Veröffentlicht in: | Nature (London) 1974-08, Vol.250 (5469), p.778-779 |
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| creator | STORM, DAN R. GUNSALUS, ROBERT P. |
| description | THE toxicity of methylmercury has taken on added importance since it was discovered that inorganic mercury can be converted to methylmercury by bacteria in bottom sediments of lakes and homogenates of rotting fish
1,2
. The mechanism for methylation of inorganic mercury by bacteria has been described in some detail
3,4
. Although there have been several documented incidents involving the toxicity of alkylmercury derivates
5–7
, the basis for methylmercury toxicity has not been defined unambiguously. One possible target site for methylmercury—the plasma membrane—is described in this communication. |
| doi_str_mv | 10.1038/250778a0 |
| format | Article |
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1,2
. The mechanism for methylation of inorganic mercury by bacteria has been described in some detail
3,4
. Although there have been several documented incidents involving the toxicity of alkylmercury derivates
5–7
, the basis for methylmercury toxicity has not been defined unambiguously. One possible target site for methylmercury—the plasma membrane—is described in this communication.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/250778a0</identifier><identifier>PMID: 4414664</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenylyl Cyclase Inhibitors ; Adenylyl Cyclases - metabolism ; Animals ; Cell Membrane - enzymology ; Fluorides - pharmacology ; Humanities and Social Sciences ; In Vitro Techniques ; letter ; Liver - cytology ; Liver - enzymology ; Methylmercury Compounds - pharmacology ; multidisciplinary ; Rats ; Science ; Science (multidisciplinary) ; Sulfhydryl Reagents - pharmacology</subject><ispartof>Nature (London), 1974-08, Vol.250 (5469), p.778-779</ispartof><rights>Springer Nature Limited 1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-c67c14f8f80fed2dfbddfe45f351649af7f1a3b76cf7f99078b2599cc0ea5b1a3</citedby><cites>FETCH-LOGICAL-c378t-c67c14f8f80fed2dfbddfe45f351649af7f1a3b76cf7f99078b2599cc0ea5b1a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/250778a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/250778a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4414664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STORM, DAN R.</creatorcontrib><creatorcontrib>GUNSALUS, ROBERT P.</creatorcontrib><title>Methylmercury is a potent inhibitor of membrane adenyl cyclase</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE toxicity of methylmercury has taken on added importance since it was discovered that inorganic mercury can be converted to methylmercury by bacteria in bottom sediments of lakes and homogenates of rotting fish
1,2
. The mechanism for methylation of inorganic mercury by bacteria has been described in some detail
3,4
. Although there have been several documented incidents involving the toxicity of alkylmercury derivates
5–7
, the basis for methylmercury toxicity has not been defined unambiguously. One possible target site for methylmercury—the plasma membrane—is described in this communication.</description><subject>Adenylyl Cyclase Inhibitors</subject><subject>Adenylyl Cyclases - metabolism</subject><subject>Animals</subject><subject>Cell Membrane - enzymology</subject><subject>Fluorides - pharmacology</subject><subject>Humanities and Social Sciences</subject><subject>In Vitro Techniques</subject><subject>letter</subject><subject>Liver - cytology</subject><subject>Liver - enzymology</subject><subject>Methylmercury Compounds - pharmacology</subject><subject>multidisciplinary</subject><subject>Rats</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sulfhydryl Reagents - pharmacology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1LxDAQhoMo67oK_gEhJ9FDddLmqxdBFr9gxYueS5pO3C79WJP20H9vZFcvnmbgeXiZeQk5Z3DDINO3qQCltIEDMmdcyYRLrQ7JHCDVCehMHpOTEDYAIJjiMzLjnHEp-ZzcveKwnpoWvR39ROtADd32A3YDrbt1XdZD72nvaItt6U2H1FTYTQ21k21MwFNy5EwT8Gw_F-Tj8eF9-Zys3p5elverxGZKD4mVyjLutNPgsEorV1aVQy5cJpjkuXHKMZOVStq45TkoXaYiz60FNKKMaEEud7lb33-NGIairYPFpokn9WModCpSITlE8WonWt-H4NEVW1-3xk8Fg-KnquK3qqhe7DPHssXqT9x3E_n1jodIuk_0xaYffRff_J_1DTOJcUU</recordid><startdate>19740830</startdate><enddate>19740830</enddate><creator>STORM, DAN R.</creator><creator>GUNSALUS, ROBERT P.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19740830</creationdate><title>Methylmercury is a potent inhibitor of membrane adenyl cyclase</title><author>STORM, DAN R. ; GUNSALUS, ROBERT P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-c67c14f8f80fed2dfbddfe45f351649af7f1a3b76cf7f99078b2599cc0ea5b1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adenylyl Cyclase Inhibitors</topic><topic>Adenylyl Cyclases - metabolism</topic><topic>Animals</topic><topic>Cell Membrane - enzymology</topic><topic>Fluorides - pharmacology</topic><topic>Humanities and Social Sciences</topic><topic>In Vitro Techniques</topic><topic>letter</topic><topic>Liver - cytology</topic><topic>Liver - enzymology</topic><topic>Methylmercury Compounds - pharmacology</topic><topic>multidisciplinary</topic><topic>Rats</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sulfhydryl Reagents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STORM, DAN R.</creatorcontrib><creatorcontrib>GUNSALUS, ROBERT P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STORM, DAN R.</au><au>GUNSALUS, ROBERT P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylmercury is a potent inhibitor of membrane adenyl cyclase</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1974-08-30</date><risdate>1974</risdate><volume>250</volume><issue>5469</issue><spage>778</spage><epage>779</epage><pages>778-779</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THE toxicity of methylmercury has taken on added importance since it was discovered that inorganic mercury can be converted to methylmercury by bacteria in bottom sediments of lakes and homogenates of rotting fish
1,2
. The mechanism for methylation of inorganic mercury by bacteria has been described in some detail
3,4
. Although there have been several documented incidents involving the toxicity of alkylmercury derivates
5–7
, the basis for methylmercury toxicity has not been defined unambiguously. One possible target site for methylmercury—the plasma membrane—is described in this communication.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4414664</pmid><doi>10.1038/250778a0</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1974-08, Vol.250 (5469), p.778-779 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature |
| subjects | Adenylyl Cyclase Inhibitors Adenylyl Cyclases - metabolism Animals Cell Membrane - enzymology Fluorides - pharmacology Humanities and Social Sciences In Vitro Techniques letter Liver - cytology Liver - enzymology Methylmercury Compounds - pharmacology multidisciplinary Rats Science Science (multidisciplinary) Sulfhydryl Reagents - pharmacology |
| title | Methylmercury is a potent inhibitor of membrane adenyl cyclase |
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