Deamination of β-phenylethylamine by monoamine oxidase—Inhibition by imipramine

The oxidative deamination of tyramine (Tyr), 5-hydroxytryptamine (5-HT), and β-phenylethylamine (PEA) by mitochondrial preparations of rabbit lung and brain was inhibited by imipramine. This tricyclic iminodibenzyl antidepressant drug was most effective in decreasing the deamination of PEA: at 1 × 1...

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Veröffentlicht in:	Biochemical pharmacology 1974-09, Vol.23 (18), p.2537-2545
Hauptverfasser:	Roth, Jerome A., Gillis, C.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - cytology Carbon Radioisotopes Deamination Desipramine - pharmacology Hydroxyindoleacetic Acid - metabolism Imipramine - pharmacology In Vitro Techniques Iproniazid - pharmacology Kinetics Lung - cytology Lung - metabolism Male Mitochondria - metabolism Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology Oxidation-Reduction Phenethylamines - metabolism Phenylacetates - metabolism Protein Binding Rabbits Serotonin - metabolism Tyramine - metabolism
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