Effect of Calcitonin and Hexestrol on Urinary Excretion of Hydroxyproline in a Patient with Prostatic Cancer and Bone Metastases
Salmon calcitonin was administered intravenously at a dose of 5 MRC units per day to a patient with prostatic cancer and bone metastases during 20 days period. Serum calcium maintained pretreatment level during the period of administration with a slight decrease after cessation of the treatment. Uri...
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| Veröffentlicht in: | Endocrinologia Japonica 1974, Vol.21(2), pp.109-113 |
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| container_end_page | 113 |
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| container_issue | 2 |
| container_start_page | 109 |
| container_title | Endocrinologia Japonica |
| container_volume | 21 |
| creator | MATSUSHITA, YOSHIKI HASEGAWA, KOICHI SUGIMURA, RYOHEI OTOMO, SEIMA MORII, HIROTOSHI OKAMOTO, TERUO WADA, MASAHISA |
| description | Salmon calcitonin was administered intravenously at a dose of 5 MRC units per day to a patient with prostatic cancer and bone metastases during 20 days period. Serum calcium maintained pretreatment level during the period of administration with a slight decrease after cessation of the treatment. Urinary total hydroxyproline showed a gradual decrease during the treatment. Serum alkaline phosphatase increased gradually, and the elevated level continued even after cessation of the administration. Urinary phosphorus increased transiently after the initiation of the administration. When hexestrol was administered intramuscularly at a total dose of 765 mg, enlarged cervical lymph nodes and metastatic lung infiltration disappeared completely at the end of the treatment. Urinary hydroxyproline began to increase at the initiation of administration, and the high value was maintained during and after the hexestrol therapy. |
| doi_str_mv | 10.1507/endocrj1954.21.109 |
| format | Article |
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Serum calcium maintained pretreatment level during the period of administration with a slight decrease after cessation of the treatment. Urinary total hydroxyproline showed a gradual decrease during the treatment. Serum alkaline phosphatase increased gradually, and the elevated level continued even after cessation of the administration. Urinary phosphorus increased transiently after the initiation of the administration. When hexestrol was administered intramuscularly at a total dose of 765 mg, enlarged cervical lymph nodes and metastatic lung infiltration disappeared completely at the end of the treatment. Urinary hydroxyproline began to increase at the initiation of administration, and the high value was maintained during and after the hexestrol therapy.</description><identifier>ISSN: 0013-7219</identifier><identifier>EISSN: 2185-6370</identifier><identifier>DOI: 10.1507/endocrj1954.21.109</identifier><identifier>PMID: 4408206</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Acid Phosphatase - blood ; Alkaline Phosphatase - blood ; Bone Neoplasms - blood ; Bone Neoplasms - enzymology ; Bone Neoplasms - urine ; Calcitonin - administration & dosage ; Calcitonin - pharmacology ; Calcium - blood ; Calcium - urine ; Hexestrol - administration & dosage ; Hexestrol - pharmacology ; Humans ; Hydroxyproline - urine ; Male ; Middle Aged ; Neoplasm Metastasis ; Phosphorus - urine ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - enzymology ; Prostatic Neoplasms - urine</subject><ispartof>Endocrinologia Japonica, 1974, Vol.21(2), pp.109-113</ispartof><rights>The Japan Endocrine Society</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4408206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATSUSHITA, YOSHIKI</creatorcontrib><creatorcontrib>HASEGAWA, KOICHI</creatorcontrib><creatorcontrib>SUGIMURA, RYOHEI</creatorcontrib><creatorcontrib>OTOMO, SEIMA</creatorcontrib><creatorcontrib>MORII, HIROTOSHI</creatorcontrib><creatorcontrib>OKAMOTO, TERUO</creatorcontrib><creatorcontrib>WADA, MASAHISA</creatorcontrib><title>Effect of Calcitonin and Hexestrol on Urinary Excretion of Hydroxyproline in a Patient with Prostatic Cancer and Bone Metastases</title><title>Endocrinologia Japonica</title><addtitle>Endocrinol Japon</addtitle><description>Salmon calcitonin was administered intravenously at a dose of 5 MRC units per day to a patient with prostatic cancer and bone metastases during 20 days period. Serum calcium maintained pretreatment level during the period of administration with a slight decrease after cessation of the treatment. Urinary total hydroxyproline showed a gradual decrease during the treatment. Serum alkaline phosphatase increased gradually, and the elevated level continued even after cessation of the administration. Urinary phosphorus increased transiently after the initiation of the administration. When hexestrol was administered intramuscularly at a total dose of 765 mg, enlarged cervical lymph nodes and metastatic lung infiltration disappeared completely at the end of the treatment. Urinary hydroxyproline began to increase at the initiation of administration, and the high value was maintained during and after the hexestrol therapy.</description><subject>Acid Phosphatase - blood</subject><subject>Alkaline Phosphatase - blood</subject><subject>Bone Neoplasms - blood</subject><subject>Bone Neoplasms - enzymology</subject><subject>Bone Neoplasms - urine</subject><subject>Calcitonin - administration & dosage</subject><subject>Calcitonin - pharmacology</subject><subject>Calcium - blood</subject><subject>Calcium - urine</subject><subject>Hexestrol - administration & dosage</subject><subject>Hexestrol - pharmacology</subject><subject>Humans</subject><subject>Hydroxyproline - urine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Phosphorus - urine</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - enzymology</subject><subject>Prostatic Neoplasms - urine</subject><issn>0013-7219</issn><issn>2185-6370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtrGzEUhUVoSY2TPxAIaJXdOHrOY9kaNw4kJItmPWg0dxKZsZRKMrV3_em9ro0J0UKCe8750D2EXHE245pVt-D7YOOKN1rNBJ9x1pyRieC1LkpZsS9kwhiXRSV4841cprRieEpRVoqdk3OlWC1YOSF_F8MANtMw0LkZrcvBO0-N7-kStpByDCMNnr5E503c0cXWRsgOJxhY7voYtrt39DgPdJ-jzyY78Jn-cfmNPseQMg4ssr2F-J_7I6D3EbJBKUG6IF8HMya4PL5T8vJz8Wu-LB6e7u7n3x8KK3WVi04bJjpRq14rKWQ5CKa1ZoZxZaDrRNlIDbVS0lSS94MWveDclrWWWnRdB3JKbg5c_O7vDW7Wrl2yMI7GQ9ikthaqkQrhUyIORou_TxGG9j26NS7fctbum28_NN8KjuMGQ9dH-qZbQ3-KHHtG_e6gr3DrVzjpJmI7I3xGisOF5JPDvpmINvkPjYyaog</recordid><startdate>19740101</startdate><enddate>19740101</enddate><creator>MATSUSHITA, YOSHIKI</creator><creator>HASEGAWA, KOICHI</creator><creator>SUGIMURA, RYOHEI</creator><creator>OTOMO, SEIMA</creator><creator>MORII, HIROTOSHI</creator><creator>OKAMOTO, TERUO</creator><creator>WADA, MASAHISA</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19740101</creationdate><title>Effect of Calcitonin and Hexestrol on Urinary Excretion of Hydroxyproline in a Patient with Prostatic Cancer and Bone Metastases</title><author>MATSUSHITA, YOSHIKI ; 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Serum calcium maintained pretreatment level during the period of administration with a slight decrease after cessation of the treatment. Urinary total hydroxyproline showed a gradual decrease during the treatment. Serum alkaline phosphatase increased gradually, and the elevated level continued even after cessation of the administration. Urinary phosphorus increased transiently after the initiation of the administration. When hexestrol was administered intramuscularly at a total dose of 765 mg, enlarged cervical lymph nodes and metastatic lung infiltration disappeared completely at the end of the treatment. Urinary hydroxyproline began to increase at the initiation of administration, and the high value was maintained during and after the hexestrol therapy.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>4408206</pmid><doi>10.1507/endocrj1954.21.109</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-7219 |
| ispartof | Endocrinologia Japonica, 1974, Vol.21(2), pp.109-113 |
| issn | 0013-7219 2185-6370 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82493454 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acid Phosphatase - blood Alkaline Phosphatase - blood Bone Neoplasms - blood Bone Neoplasms - enzymology Bone Neoplasms - urine Calcitonin - administration & dosage Calcitonin - pharmacology Calcium - blood Calcium - urine Hexestrol - administration & dosage Hexestrol - pharmacology Humans Hydroxyproline - urine Male Middle Aged Neoplasm Metastasis Phosphorus - urine Prostatic Neoplasms - blood Prostatic Neoplasms - enzymology Prostatic Neoplasms - urine |
| title | Effect of Calcitonin and Hexestrol on Urinary Excretion of Hydroxyproline in a Patient with Prostatic Cancer and Bone Metastases |
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