MICROBIAL CONVERSION OF ANTIBIOTICS. I: DEACYLATION OF MARIDOMYCIN BY BACTERIA

Maridomycin, a macrolide antibiotic, was hydrolyzed to 4"-deacylmaridomycin byesterases obtained from many bacteria. Among these bacteria, Bacillus megaterium91277 showed the highest activity. The properties of the esterase were investigated by using cell-free extract obtained from B. megateriu...

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Veröffentlicht in:	Journal of antibiotics 1974, Vol.27(6), pp.425-432
Hauptverfasser:	NAKAHAMA, KAZUO, IZAWA, MOTOWO, MUROI, MASAYUKI, KISHI, TOYOKAZU, UCHIDA, MINORU, IGARASI, SEIZI
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Anti-Bacterial Agents - metabolism Bacillus megaterium - enzymology Bacteria - enzymology Chemical Phenomena Chemistry Chromatography, Thin Layer Esterases - analysis Esterases - metabolism Hydrogen-Ion Concentration Hydrolysis
Online-Zugang:	Volltext
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