The Effect of Isoproterenol Sulfate Aerosol on the Small Airways in Asymptomatic Asthmatic Patients
In 19 asymptomatic asthmatic patients the effect of isoproterenol sulfate aerosol on small airways was assessed. All patients were symptom-free for at least three days before the investigation. On the day of examination, before inhalation of isoproterenol, the total lung resistance (RL) was normal,...
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| Veröffentlicht in: | Chest 1974-08, Vol.66 (2), p.133-135 |
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| container_title | Chest |
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| creator | Rubin, Ami-Hai E. Schey, George Bruderman, Israel |
| description | In 19 asymptomatic asthmatic patients the effect of isoproterenol sulfate aerosol on small airways was assessed. All patients were symptom-free for at least three days before the investigation. On the day of examination, before inhalation of isoproterenol, the total lung resistance (RL) was normal, while the frequency dependence of lung compliance (Cdyn) was increased, indicating an obstruction of airways with an inner diameter of less than 2 to 3 mm. After inhalation of 400 micrograms of isoproterenol, no statistically significant change in Cdyn occurred up to one hour. From our results we assume that in the early stage of recovery from an acute asthmatic attack, isoproterenol aerosol has no effect on the obstruction of peripheral airways. |
| doi_str_mv | 10.1378/chest.66.2.133 |
| format | Article |
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All patients were symptom-free for at least three days before the investigation. On the day of examination, before inhalation of isoproterenol, the total lung resistance (RL) was normal, while the frequency dependence of lung compliance (Cdyn) was increased, indicating an obstruction of airways with an inner diameter of less than 2 to 3 mm. After inhalation of 400 micrograms of isoproterenol, no statistically significant change in Cdyn occurred up to one hour. From our results we assume that in the early stage of recovery from an acute asthmatic attack, isoproterenol aerosol has no effect on the obstruction of peripheral airways.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.66.2.133</identifier><identifier>PMID: 4854763</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aerosols ; Airway Obstruction - drug therapy ; Airway Resistance - drug effects ; Asthma - drug therapy ; Female ; Humans ; Isoproterenol - administration & dosage ; Isoproterenol - pharmacology ; Isoproterenol - therapeutic use ; Lung Compliance - drug effects ; Male ; Middle Aged ; Muscle Tonus - drug effects ; Muscle, Smooth - drug effects ; Respiration - drug effects</subject><ispartof>Chest, 1974-08, Vol.66 (2), p.133-135</ispartof><rights>1974 The American College of Chest Physicians</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-6903b11c5e82deded4ac8cc08595eaa7ee5d98e87038e188c38bbaa09645bda3</citedby><cites>FETCH-LOGICAL-c378t-6903b11c5e82deded4ac8cc08595eaa7ee5d98e87038e188c38bbaa09645bda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4854763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rubin, Ami-Hai E.</creatorcontrib><creatorcontrib>Schey, George</creatorcontrib><creatorcontrib>Bruderman, Israel</creatorcontrib><title>The Effect of Isoproterenol Sulfate Aerosol on the Small Airways in Asymptomatic Asthmatic Patients</title><title>Chest</title><addtitle>Chest</addtitle><description>In 19 asymptomatic asthmatic patients the effect of isoproterenol sulfate aerosol on small airways was assessed. All patients were symptom-free for at least three days before the investigation. On the day of examination, before inhalation of isoproterenol, the total lung resistance (RL) was normal, while the frequency dependence of lung compliance (Cdyn) was increased, indicating an obstruction of airways with an inner diameter of less than 2 to 3 mm. After inhalation of 400 micrograms of isoproterenol, no statistically significant change in Cdyn occurred up to one hour. From our results we assume that in the early stage of recovery from an acute asthmatic attack, isoproterenol aerosol has no effect on the obstruction of peripheral airways.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aerosols</subject><subject>Airway Obstruction - drug therapy</subject><subject>Airway Resistance - drug effects</subject><subject>Asthma - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Isoproterenol - administration & dosage</subject><subject>Isoproterenol - pharmacology</subject><subject>Isoproterenol - therapeutic use</subject><subject>Lung Compliance - drug effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Tonus - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Respiration - drug effects</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFr2zAUxkVZ6bKu194GOu3mTLJsRT6GkraBwgrJXcjyc61iW5kkL-S_38sctl2GQNIH3_t434-Qe86WXKzUN9tBTEsplzlqcUUWvBI8E2UhPpAFYzzPhKzyj-RTjO8MNa_kDbkpVFmspFgQu--AbtoWbKK-pdvoD8EnCDD6nu6mvjUJ6BqCj6j9SBPad4Ppe7p24WhOkbqRruNpOCQ_mOQsitTNv1e8YUzxM7luTR_h7vLekv3jZv_wnL18f9o-rF8yi0VSJismas5tCSpvAE9hrLKWqbIqwZgVQNlUCtSKCQVcKStUXRvDKlmUdWPELfk6x2KDHxNS0YOLFvrejOCnqFWOlatcoHE5Gy3WigFafQhuMOGkOdNnqPo3VC2lzlGfB75ckqd6gOaP_ULxb2Dn3rqjC6DjGRG6xRz17qcwmv6fQDUPAOL46SDoaBGVhQaHbdKNd__b5RenWJl_</recordid><startdate>197408</startdate><enddate>197408</enddate><creator>Rubin, Ami-Hai E.</creator><creator>Schey, George</creator><creator>Bruderman, Israel</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197408</creationdate><title>The Effect of Isoproterenol Sulfate Aerosol on the Small Airways in Asymptomatic Asthmatic Patients</title><author>Rubin, Ami-Hai E. ; Schey, George ; Bruderman, Israel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-6903b11c5e82deded4ac8cc08595eaa7ee5d98e87038e188c38bbaa09645bda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aerosols</topic><topic>Airway Obstruction - drug therapy</topic><topic>Airway Resistance - drug effects</topic><topic>Asthma - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Isoproterenol - administration & dosage</topic><topic>Isoproterenol - pharmacology</topic><topic>Isoproterenol - therapeutic use</topic><topic>Lung Compliance - drug effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Tonus - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Respiration - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rubin, Ami-Hai E.</creatorcontrib><creatorcontrib>Schey, George</creatorcontrib><creatorcontrib>Bruderman, Israel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rubin, Ami-Hai E.</au><au>Schey, George</au><au>Bruderman, Israel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Isoproterenol Sulfate Aerosol on the Small Airways in Asymptomatic Asthmatic Patients</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1974-08</date><risdate>1974</risdate><volume>66</volume><issue>2</issue><spage>133</spage><epage>135</epage><pages>133-135</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><abstract>In 19 asymptomatic asthmatic patients the effect of isoproterenol sulfate aerosol on small airways was assessed. All patients were symptom-free for at least three days before the investigation. On the day of examination, before inhalation of isoproterenol, the total lung resistance (RL) was normal, while the frequency dependence of lung compliance (Cdyn) was increased, indicating an obstruction of airways with an inner diameter of less than 2 to 3 mm. After inhalation of 400 micrograms of isoproterenol, no statistically significant change in Cdyn occurred up to one hour. From our results we assume that in the early stage of recovery from an acute asthmatic attack, isoproterenol aerosol has no effect on the obstruction of peripheral airways.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4854763</pmid><doi>10.1378/chest.66.2.133</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1974-08, Vol.66 (2), p.133-135 |
| issn | 0012-3692 1931-3543 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aerosols Airway Obstruction - drug therapy Airway Resistance - drug effects Asthma - drug therapy Female Humans Isoproterenol - administration & dosage Isoproterenol - pharmacology Isoproterenol - therapeutic use Lung Compliance - drug effects Male Middle Aged Muscle Tonus - drug effects Muscle, Smooth - drug effects Respiration - drug effects |
| title | The Effect of Isoproterenol Sulfate Aerosol on the Small Airways in Asymptomatic Asthmatic Patients |
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