Influence of dietary factors on the gastrointestinal absorption of lead
Gastrointestinal absorption of lead was investigated in mice after oral administration of lead acetate labeled with 210Pb. When doses of 0.2, 2 and 20 mg of Pb/kg were given, the magnitude of the dose did not appear to affect significantly the percent absorbed. The presence of food in the gastrointe...
Gespeichert in:
| Veröffentlicht in: | Toxicology and applied pharmacology 1974-03, Vol.27 (3), p.685-691 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 691 |
|---|---|
| container_issue | 3 |
| container_start_page | 685 |
| container_title | Toxicology and applied pharmacology |
| container_volume | 27 |
| creator | Garber, Brad T. Wei, Eddie |
| description | Gastrointestinal absorption of lead was investigated in mice after oral administration of lead acetate labeled with
210Pb. When doses of 0.2, 2 and 20 mg of Pb/kg were given, the magnitude of the dose did not appear to affect significantly the percent absorbed. The presence of food in the gastrointestinal tract reduced lead absorption when a tracer dose was administered but did not affect absorption after 2 mg of Pb/kg po. The chelators nitrilotriacetic acid and sodium citrate increased absorption of lead, as did orange juice, a source of citric acid. Milk and the chelating agents, ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid, did not affect significantly lead absorption. |
| doi_str_mv | 10.1016/0041-008X(74)90048-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_82469909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0041008X74900489</els_id><sourcerecordid>82469909</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-e0daa83a88886b483f5f89425bdc6d089c73a99ddcdfc3afdc683fd1239536033</originalsourceid><addsrcrecordid>eNp9kM1KAzEUhYMotVbfQGFWoovRm0k6k2wEKVoLBTcK7kKaH41MJzXJCL69GVu6NJuQnHNucj6EzjHcYMD1LQDFJQB7u2roNc8nVvIDNMbA6xIIIYdovLcco5MYPwGAU4pHaEQrXAFjYzRfdLbtTadM4W2hnUky_BRWquRDLHxXpA9TvMuYgnddMjG5TraFXEUfNsllPadaI_UpOrKyjeZst0_Q6-PDy-ypXD7PF7P7ZanItEmlAS0lI5LlVa8oI3ZqGafVdKVVrYFx1RDJudZKW0WkzbfZo3FF-JTUudUEXW7nboL_6vN_xNpFZdpWdsb3UbCK1pwDz0a6NargYwzGik1w61xOYBADPzHAEQMc0VDxx08MsYvd_H61Nnof2gHL-t1WN7nktzNBROUGfNoFo5LQ3v3_wC8GLn_8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>82469909</pqid></control><display><type>article</type><title>Influence of dietary factors on the gastrointestinal absorption of lead</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Garber, Brad T. ; Wei, Eddie</creator><creatorcontrib>Garber, Brad T. ; Wei, Eddie</creatorcontrib><description>Gastrointestinal absorption of lead was investigated in mice after oral administration of lead acetate labeled with
210Pb. When doses of 0.2, 2 and 20 mg of Pb/kg were given, the magnitude of the dose did not appear to affect significantly the percent absorbed. The presence of food in the gastrointestinal tract reduced lead absorption when a tracer dose was administered but did not affect absorption after 2 mg of Pb/kg po. The chelators nitrilotriacetic acid and sodium citrate increased absorption of lead, as did orange juice, a source of citric acid. Milk and the chelating agents, ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid, did not affect significantly lead absorption.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/0041-008X(74)90048-9</identifier><identifier>PMID: 4212088</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acetates - metabolism ; Animals ; Chelating Agents - pharmacology ; Diet ; Dose-Response Relationship, Drug ; Edetic Acid - pharmacology ; Intestinal Absorption ; Lead - metabolism ; Male ; Mice ; Nitrilotriacetic Acid - pharmacology ; Penicillamine - pharmacology ; Pentetic Acid - pharmacology ; Radioisotopes ; Time Factors</subject><ispartof>Toxicology and applied pharmacology, 1974-03, Vol.27 (3), p.685-691</ispartof><rights>1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e0daa83a88886b483f5f89425bdc6d089c73a99ddcdfc3afdc683fd1239536033</citedby><cites>FETCH-LOGICAL-c357t-e0daa83a88886b483f5f89425bdc6d089c73a99ddcdfc3afdc683fd1239536033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0041008X74900489$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4212088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garber, Brad T.</creatorcontrib><creatorcontrib>Wei, Eddie</creatorcontrib><title>Influence of dietary factors on the gastrointestinal absorption of lead</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>Gastrointestinal absorption of lead was investigated in mice after oral administration of lead acetate labeled with
210Pb. When doses of 0.2, 2 and 20 mg of Pb/kg were given, the magnitude of the dose did not appear to affect significantly the percent absorbed. The presence of food in the gastrointestinal tract reduced lead absorption when a tracer dose was administered but did not affect absorption after 2 mg of Pb/kg po. The chelators nitrilotriacetic acid and sodium citrate increased absorption of lead, as did orange juice, a source of citric acid. Milk and the chelating agents, ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid, did not affect significantly lead absorption.</description><subject>Acetates - metabolism</subject><subject>Animals</subject><subject>Chelating Agents - pharmacology</subject><subject>Diet</subject><subject>Dose-Response Relationship, Drug</subject><subject>Edetic Acid - pharmacology</subject><subject>Intestinal Absorption</subject><subject>Lead - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Nitrilotriacetic Acid - pharmacology</subject><subject>Penicillamine - pharmacology</subject><subject>Pentetic Acid - pharmacology</subject><subject>Radioisotopes</subject><subject>Time Factors</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEUhYMotVbfQGFWoovRm0k6k2wEKVoLBTcK7kKaH41MJzXJCL69GVu6NJuQnHNucj6EzjHcYMD1LQDFJQB7u2roNc8nVvIDNMbA6xIIIYdovLcco5MYPwGAU4pHaEQrXAFjYzRfdLbtTadM4W2hnUky_BRWquRDLHxXpA9TvMuYgnddMjG5TraFXEUfNsllPadaI_UpOrKyjeZst0_Q6-PDy-ypXD7PF7P7ZanItEmlAS0lI5LlVa8oI3ZqGafVdKVVrYFx1RDJudZKW0WkzbfZo3FF-JTUudUEXW7nboL_6vN_xNpFZdpWdsb3UbCK1pwDz0a6NargYwzGik1w61xOYBADPzHAEQMc0VDxx08MsYvd_H61Nnof2gHL-t1WN7nktzNBROUGfNoFo5LQ3v3_wC8GLn_8</recordid><startdate>197403</startdate><enddate>197403</enddate><creator>Garber, Brad T.</creator><creator>Wei, Eddie</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197403</creationdate><title>Influence of dietary factors on the gastrointestinal absorption of lead</title><author>Garber, Brad T. ; Wei, Eddie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e0daa83a88886b483f5f89425bdc6d089c73a99ddcdfc3afdc683fd1239536033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Acetates - metabolism</topic><topic>Animals</topic><topic>Chelating Agents - pharmacology</topic><topic>Diet</topic><topic>Dose-Response Relationship, Drug</topic><topic>Edetic Acid - pharmacology</topic><topic>Intestinal Absorption</topic><topic>Lead - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Nitrilotriacetic Acid - pharmacology</topic><topic>Penicillamine - pharmacology</topic><topic>Pentetic Acid - pharmacology</topic><topic>Radioisotopes</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garber, Brad T.</creatorcontrib><creatorcontrib>Wei, Eddie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garber, Brad T.</au><au>Wei, Eddie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of dietary factors on the gastrointestinal absorption of lead</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>1974-03</date><risdate>1974</risdate><volume>27</volume><issue>3</issue><spage>685</spage><epage>691</epage><pages>685-691</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><abstract>Gastrointestinal absorption of lead was investigated in mice after oral administration of lead acetate labeled with
210Pb. When doses of 0.2, 2 and 20 mg of Pb/kg were given, the magnitude of the dose did not appear to affect significantly the percent absorbed. The presence of food in the gastrointestinal tract reduced lead absorption when a tracer dose was administered but did not affect absorption after 2 mg of Pb/kg po. The chelators nitrilotriacetic acid and sodium citrate increased absorption of lead, as did orange juice, a source of citric acid. Milk and the chelating agents, ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid, did not affect significantly lead absorption.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4212088</pmid><doi>10.1016/0041-008X(74)90048-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-008X |
| ispartof | Toxicology and applied pharmacology, 1974-03, Vol.27 (3), p.685-691 |
| issn | 0041-008X 1096-0333 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82469909 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetates - metabolism Animals Chelating Agents - pharmacology Diet Dose-Response Relationship, Drug Edetic Acid - pharmacology Intestinal Absorption Lead - metabolism Male Mice Nitrilotriacetic Acid - pharmacology Penicillamine - pharmacology Pentetic Acid - pharmacology Radioisotopes Time Factors |
| title | Influence of dietary factors on the gastrointestinal absorption of lead |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T07%3A10%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20dietary%20factors%20on%20the%20gastrointestinal%20absorption%20of%20lead&rft.jtitle=Toxicology%20and%20applied%20pharmacology&rft.au=Garber,%20Brad%20T.&rft.date=1974-03&rft.volume=27&rft.issue=3&rft.spage=685&rft.epage=691&rft.pages=685-691&rft.issn=0041-008X&rft.eissn=1096-0333&rft_id=info:doi/10.1016/0041-008X(74)90048-9&rft_dat=%3Cproquest_cross%3E82469909%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=82469909&rft_id=info:pmid/4212088&rft_els_id=0041008X74900489&rfr_iscdi=true |