The mechanics of breathing and stabilization of ventilation in patients with unilateral cerebral infarction
The mechanics of breathing and responses of the respiratory system to CO 2 during resistance breathing were studied in 12 patients with clinical evidence of unilateral cerebral infarction and compared with the findings in normal subjects. The respiratory abnormalities in patients with cerebrovascula...
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| Veröffentlicht in: | Stroke (1970) 1974-07, Vol.5 (4), p.518-527 |
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| container_title | Stroke (1970) |
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| creator | McMahon, S M Heyman, A |
| description | The mechanics of breathing and responses of the respiratory system to CO
2
during resistance breathing were studied in 12 patients with clinical evidence of unilateral cerebral infarction and compared with the findings in normal subjects. The respiratory abnormalities in patients with cerebrovascular disease consisted of noncompliant lungs and high levels of elastic and nonelastic work while rebreathing CO
2
. There were no differences in responses of minute ventilation to CO
2
in the two groups. Unlike normal subjects, the patients did not increase their level of respiratory work to compensate for the addition of a modest external resistance to airflow, and the ventilatory response to CO
2
, consequently, became less than in the normal subjects. This failure to maintain tidal volumes and minute ventilation while breathing through an external resistance may account for some instances of respiratory deterioration among patients with cerebrovascular disease. |
| doi_str_mv | 10.1161/01.STR.5.4.518 |
| format | Article |
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2
during resistance breathing were studied in 12 patients with clinical evidence of unilateral cerebral infarction and compared with the findings in normal subjects. The respiratory abnormalities in patients with cerebrovascular disease consisted of noncompliant lungs and high levels of elastic and nonelastic work while rebreathing CO
2
. There were no differences in responses of minute ventilation to CO
2
in the two groups. Unlike normal subjects, the patients did not increase their level of respiratory work to compensate for the addition of a modest external resistance to airflow, and the ventilatory response to CO
2
, consequently, became less than in the normal subjects. This failure to maintain tidal volumes and minute ventilation while breathing through an external resistance may account for some instances of respiratory deterioration among patients with cerebrovascular disease.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.5.4.518</identifier><identifier>PMID: 4854946</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Blood Gas Analysis ; Carbon Dioxide - blood ; Carbon Dioxide - pharmacology ; Cerebrovascular Disorders - physiopathology ; Electroencephalography ; Female ; Functional Laterality ; Humans ; Lung Compliance ; Male ; Middle Aged ; Oxygen - blood ; Pulmonary Ventilation ; Radionuclide Imaging ; Respiration - drug effects ; Respiratory Function Tests ; Ventilation-Perfusion Ratio ; Vital Capacity ; Work of Breathing</subject><ispartof>Stroke (1970), 1974-07, Vol.5 (4), p.518-527</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-e4ec40fd8ceb01545244e9087932a1b63982589f4bb80b338ecda089ba1374f23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4854946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McMahon, S M</creatorcontrib><creatorcontrib>Heyman, A</creatorcontrib><title>The mechanics of breathing and stabilization of ventilation in patients with unilateral cerebral infarction</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>The mechanics of breathing and responses of the respiratory system to CO
2
during resistance breathing were studied in 12 patients with clinical evidence of unilateral cerebral infarction and compared with the findings in normal subjects. The respiratory abnormalities in patients with cerebrovascular disease consisted of noncompliant lungs and high levels of elastic and nonelastic work while rebreathing CO
2
. There were no differences in responses of minute ventilation to CO
2
in the two groups. Unlike normal subjects, the patients did not increase their level of respiratory work to compensate for the addition of a modest external resistance to airflow, and the ventilatory response to CO
2
, consequently, became less than in the normal subjects. This failure to maintain tidal volumes and minute ventilation while breathing through an external resistance may account for some instances of respiratory deterioration among patients with cerebrovascular disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Gas Analysis</subject><subject>Carbon Dioxide - blood</subject><subject>Carbon Dioxide - pharmacology</subject><subject>Cerebrovascular Disorders - physiopathology</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Humans</subject><subject>Lung Compliance</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen - blood</subject><subject>Pulmonary Ventilation</subject><subject>Radionuclide Imaging</subject><subject>Respiration - drug effects</subject><subject>Respiratory Function Tests</subject><subject>Ventilation-Perfusion Ratio</subject><subject>Vital Capacity</subject><subject>Work of Breathing</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LxDAQxYMo67p69Sbk5K01aZJuchTxCxYEXc8hSac22k3XpFX0r7dlF0_zZt6bgfkhdE5JTmlJrwjNX9bPuch5Lqg8QHMqCp7xspCHaE4IU1nBlTpGJym9E0IKJsUMzbgUXPFyjj7WDeANuMYE7xLuamwjmL7x4Q2bUOHUG-tb_2t634XJ_oLQ-3bX-oC3oxonCX_7vsFDmCyIpsUOIthJ-FCb6Kb8KTqqTZvgbF8X6PXudn3zkK2e7h9vrleZYyXvM-DgOKkr6cASKvj4DwdF5FKxwlBbMiULIVXNrZXEMibBVYZIZQ1lS14XbIEud3e3sfscIPV645ODtjUBuiFpWfBSjVDGYL4LutilFKHW2-g3Jv5oSvREVxOqR7paaK5HuuPCxf7yYDdQ_cf3ONkfYXZ3PQ</recordid><startdate>197407</startdate><enddate>197407</enddate><creator>McMahon, S M</creator><creator>Heyman, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197407</creationdate><title>The mechanics of breathing and stabilization of ventilation in patients with unilateral cerebral infarction</title><author>McMahon, S M ; Heyman, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-e4ec40fd8ceb01545244e9087932a1b63982589f4bb80b338ecda089ba1374f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Gas Analysis</topic><topic>Carbon Dioxide - blood</topic><topic>Carbon Dioxide - pharmacology</topic><topic>Cerebrovascular Disorders - physiopathology</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Humans</topic><topic>Lung Compliance</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen - blood</topic><topic>Pulmonary Ventilation</topic><topic>Radionuclide Imaging</topic><topic>Respiration - drug effects</topic><topic>Respiratory Function Tests</topic><topic>Ventilation-Perfusion Ratio</topic><topic>Vital Capacity</topic><topic>Work of Breathing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McMahon, S M</creatorcontrib><creatorcontrib>Heyman, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McMahon, S M</au><au>Heyman, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mechanics of breathing and stabilization of ventilation in patients with unilateral cerebral infarction</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>1974-07</date><risdate>1974</risdate><volume>5</volume><issue>4</issue><spage>518</spage><epage>527</epage><pages>518-527</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>The mechanics of breathing and responses of the respiratory system to CO
2
during resistance breathing were studied in 12 patients with clinical evidence of unilateral cerebral infarction and compared with the findings in normal subjects. The respiratory abnormalities in patients with cerebrovascular disease consisted of noncompliant lungs and high levels of elastic and nonelastic work while rebreathing CO
2
. There were no differences in responses of minute ventilation to CO
2
in the two groups. Unlike normal subjects, the patients did not increase their level of respiratory work to compensate for the addition of a modest external resistance to airflow, and the ventilatory response to CO
2
, consequently, became less than in the normal subjects. This failure to maintain tidal volumes and minute ventilation while breathing through an external resistance may account for some instances of respiratory deterioration among patients with cerebrovascular disease.</abstract><cop>United States</cop><pmid>4854946</pmid><doi>10.1161/01.STR.5.4.518</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 1974-07, Vol.5 (4), p.518-527 |
| issn | 0039-2499 1524-4628 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Blood Gas Analysis Carbon Dioxide - blood Carbon Dioxide - pharmacology Cerebrovascular Disorders - physiopathology Electroencephalography Female Functional Laterality Humans Lung Compliance Male Middle Aged Oxygen - blood Pulmonary Ventilation Radionuclide Imaging Respiration - drug effects Respiratory Function Tests Ventilation-Perfusion Ratio Vital Capacity Work of Breathing |
| title | The mechanics of breathing and stabilization of ventilation in patients with unilateral cerebral infarction |
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