HEMORRHAGIC FEVER IN COCHABAMBA, BOLIVIA, 1971
Between January and March 1971, an unusual outbreak of hemorrhagic fever occurred in Cochabamba, Bolivia. The index case was apparently infected elsewhere, but became ill in Cochabamba, where hemorrhagic fever had never been reported. Four secondary cases occurred among hospital contacts of the inde...
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| Veröffentlicht in: | American journal of epidemiology 1974-06, Vol.99 (6), p.425-433 |
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| container_end_page | 433 |
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| container_issue | 6 |
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| container_title | American journal of epidemiology |
| container_volume | 99 |
| creator | PETERS, C. J. KUEHNE, R. W. MERCADO, R. R. LE BOW, R. H. SPERTZEL, R. O. WEBB, P. A. |
| description | Between January and March 1971, an unusual outbreak of hemorrhagic fever occurred in Cochabamba, Bolivia. The index case was apparently infected elsewhere, but became ill in Cochabamba, where hemorrhagic fever had never been reported. Four secondary cases occurred among hospital contacts of the index case, and a pathologist was infected after cutting himself during an autopsy of one of the secondary cases. Clinical manifestations were typical of Bolivian hemorrhagic fever, except that jaundice occurred in three cases. An arenavirus of the Tacaribe complex was isolated from three cases. One isolate was studied in detail and shown to be closely related antigenically to the prototype strains of Machupo virus. |
| doi_str_mv | 10.1093/oxfordjournals.aje.a121631 |
| format | Article |
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J. ; KUEHNE, R. W. ; MERCADO, R. R. ; LE BOW, R. H. ; SPERTZEL, R. O. ; WEBB, P. A.</creator><creatorcontrib>PETERS, C. J. ; KUEHNE, R. W. ; MERCADO, R. R. ; LE BOW, R. H. ; SPERTZEL, R. O. ; WEBB, P. A.</creatorcontrib><description>Between January and March 1971, an unusual outbreak of hemorrhagic fever occurred in Cochabamba, Bolivia. The index case was apparently infected elsewhere, but became ill in Cochabamba, where hemorrhagic fever had never been reported. Four secondary cases occurred among hospital contacts of the index case, and a pathologist was infected after cutting himself during an autopsy of one of the secondary cases. Clinical manifestations were typical of Bolivian hemorrhagic fever, except that jaundice occurred in three cases. An arenavirus of the Tacaribe complex was isolated from three cases. 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One isolate was studied in detail and shown to be closely related antigenically to the prototype strains of Machupo virus.</description><subject>Adult</subject><subject>Animals</subject><subject>Antibodies, Viral - analysis</subject><subject>Arboviruses - isolation & purification</subject><subject>arenavirus</subject><subject>Autopsy</subject><subject>Blood - microbiology</subject><subject>Bolivia</subject><subject>Cell Line</subject><subject>Cells, Cultured</subject><subject>Complement Fixation Tests</subject><subject>Cricetinae</subject><subject>etiology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>hemorrhagic fever</subject><subject>Hemorrhagic Fevers, Viral - epidemiology</subject><subject>Hemorrhagic Fevers, Viral - microbiology</subject><subject>Humans</subject><subject>jaundice</subject><subject>Liver - microbiology</subject><subject>Machupo virus</subject><subject>Male</subject><subject>Mice</subject><subject>Neutralization Tests</subject><subject>Pharynx - microbiology</subject><subject>Spleen - microbiology</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNpdkNFKwzAUhoMoc04fQSgKXtl5TtOkjXdd2eygW2HMId6EtEthc1tns8F8eyOrA71K4P_-czgfIXcIXQRBn6pDWdXzZbWvN2plumqpuwo95BTPSBv9gLvcY_yctAHAc4XHvUtyZcwSAFEwaJGWzwG5EG3STfqjbDJJopdh7Az6s_7EGY6dOIuTqBeNetGj08vS4WxoPygCvCYXpV2pb5q3Q14H_WmcuGlmB0SpW9AQdi4V3OMwRxbkHHUhSs1yzQDLQKBfFgoKj4cW8FlAA8qEzue5b0s6FypUNKcd8nCcu62rz702O7lemEKvVmqjq72RoeczewBa8P4f-KtFIgXOfU5DYannI1XUlTG1LuW2XqxV_SUR5I9S-VeptEplo9SWb5sV-3yt56dq49Dm7jFfmJ0-nGJVf0huz2MyeXuXs_EogHQaS6DfsuSAnQ</recordid><startdate>197406</startdate><enddate>197406</enddate><creator>PETERS, C. 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J.</au><au>KUEHNE, R. W.</au><au>MERCADO, R. R.</au><au>LE BOW, R. H.</au><au>SPERTZEL, R. O.</au><au>WEBB, P. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HEMORRHAGIC FEVER IN COCHABAMBA, BOLIVIA, 1971</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>1974-06</date><risdate>1974</risdate><volume>99</volume><issue>6</issue><spage>425</spage><epage>433</epage><pages>425-433</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><abstract>Between January and March 1971, an unusual outbreak of hemorrhagic fever occurred in Cochabamba, Bolivia. The index case was apparently infected elsewhere, but became ill in Cochabamba, where hemorrhagic fever had never been reported. Four secondary cases occurred among hospital contacts of the index case, and a pathologist was infected after cutting himself during an autopsy of one of the secondary cases. Clinical manifestations were typical of Bolivian hemorrhagic fever, except that jaundice occurred in three cases. An arenavirus of the Tacaribe complex was isolated from three cases. One isolate was studied in detail and shown to be closely related antigenically to the prototype strains of Machupo virus.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>4601699</pmid><doi>10.1093/oxfordjournals.aje.a121631</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0002-9262 |
| ispartof | American journal of epidemiology, 1974-06, Vol.99 (6), p.425-433 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Periodicals Index Online |
| subjects | Adult Animals Antibodies, Viral - analysis Arboviruses - isolation & purification arenavirus Autopsy Blood - microbiology Bolivia Cell Line Cells, Cultured Complement Fixation Tests Cricetinae etiology Female Fluorescent Antibody Technique hemorrhagic fever Hemorrhagic Fevers, Viral - epidemiology Hemorrhagic Fevers, Viral - microbiology Humans jaundice Liver - microbiology Machupo virus Male Mice Neutralization Tests Pharynx - microbiology Spleen - microbiology |
| title | HEMORRHAGIC FEVER IN COCHABAMBA, BOLIVIA, 1971 |
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