Effect of chronic treatment with phenobarbital or 3-methylcholanthrene on the male reproductive system in rats

Treatment of rats for 4 weeks with phenobarbital (PB) did not inhibit the growth of the seminal vesicles, nor did it affect the biosynthesis of testosterone by testis microsomes. Moreover, neither the concentration of cytochrome p-450 or the 17 α-hydroxylase activity in testis microsomes were affect...

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Veröffentlicht in:	Life sciences (1973) 1974-06, Vol.14 (11), p.2121-2130
Hauptverfasser:	Stripp, Bitten, Menard, Raymond H., Gillette, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight Carbon Radioisotopes Chromatography, Thin Layer Cytochrome P-450 Enzyme System - metabolism Male Methylcholanthrene - pharmacology Microsomes - drug effects Microsomes - enzymology Microsomes - metabolism Organ Size Phenobarbital - pharmacology Progesterone - metabolism Rats Reproduction - drug effects Seminal Vesicles - drug effects Seminal Vesicles - metabolism Spectrophotometry Steroid Hydroxylases - metabolism Testis - cytology Testis - drug effects Testis - metabolism Testosterone - biosynthesis
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