Effects of Intracarotid Injections of Hypertonic Solutions on Arterial Pressure in the Rabbit
The intracarotid injection of hypertonic saline in the rabbit induces a brief drop in arterial pressure followed by a somewhat longer pressor phase. The “osmoreceptors” activating these changes are related to the hindbrain and are not the elements responsible for releasing neurohypophysial hormones....
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| Veröffentlicht in: | Circulation research 1959-09, Vol.7 (5), p.712-720 |
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| container_title | Circulation research |
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| creator | Holland, Robert C Sundsten, John W Sawyer, Charles H |
| description | The intracarotid injection of hypertonic saline in the rabbit induces a brief drop in arterial pressure followed by a somewhat longer pressor phase. The “osmoreceptors” activating these changes are related to the hindbrain and are not the elements responsible for releasing neurohypophysial hormones. The pressure changes are not prevented by vagotomy, deafferentation of the carotid body and sinus, adrenalectomy, or parasympathetic blockade. The blood pressure effects are interpreted as resulting from sequential inhibition and stimulation of medullary vasomotor centers by the hypertonic solutions. |
| doi_str_mv | 10.1161/01.RES.7.5.712 |
| format | Article |
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The “osmoreceptors” activating these changes are related to the hindbrain and are not the elements responsible for releasing neurohypophysial hormones. The pressure changes are not prevented by vagotomy, deafferentation of the carotid body and sinus, adrenalectomy, or parasympathetic blockade. 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The “osmoreceptors” activating these changes are related to the hindbrain and are not the elements responsible for releasing neurohypophysial hormones. The pressure changes are not prevented by vagotomy, deafferentation of the carotid body and sinus, adrenalectomy, or parasympathetic blockade. The blood pressure effects are interpreted as resulting from sequential inhibition and stimulation of medullary vasomotor centers by the hypertonic solutions.</description><subject>Animals</subject><subject>Blood Pressure - pharmacology</subject><subject>Hypertonic Solutions - pharmacology</subject><subject>Injections</subject><subject>Old Medline</subject><subject>Pressure</subject><subject>Rabbits</subject><subject>Sodium Chloride - pharmacology</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1959</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFr3DAQRkVJaTZprz0Wn3KzOyPJlnwMYdMEAilJeyxCssesU6-1lWSW_Ptqsws5DfPNmzm8YewrQoXY4HfA6mn9XKmqrhTyD2yFNZelrBWesRUAtKUSAs7ZRYwvACgFbz-xc5QSeINixf6sh4G6FAs_FPdzCrazwaexz81Lzkc_v43uXncUkp_Hrnj203LK5-I6JAqjnYqfgWJcAhXjXKQNFU_WuTF9Zh8HO0X6cqqX7Pft-tfNXfnw-OP-5vqh7CSiLutmaFugWglCQiedanqnLFDvgDvtSAnb9B2QVVyrjktNWtIgW4QetNPikl0d7-6C_7dQTGY7xo6myc7kl2g0l7IGdQCrI9gFH2OgwezCuLXh1SCYg1ADaLJQo0xtstC88O10eXFb6t_xk8EMyCOw91N2Ef9Oy56C2ZCd0sbkD4AA5CW2dQtt7spDpMV_HOCBLA</recordid><startdate>195909</startdate><enddate>195909</enddate><creator>Holland, Robert C</creator><creator>Sundsten, John W</creator><creator>Sawyer, Charles H</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195909</creationdate><title>Effects of Intracarotid Injections of Hypertonic Solutions on Arterial Pressure in the Rabbit</title><author>Holland, Robert C ; Sundsten, John W ; Sawyer, Charles H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4118-56f990e573e1e1b4b76db7a0edb02b8be73a6dc0ea7287c248e84ef4910d08b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1959</creationdate><topic>Animals</topic><topic>Blood Pressure - pharmacology</topic><topic>Hypertonic Solutions - pharmacology</topic><topic>Injections</topic><topic>Old Medline</topic><topic>Pressure</topic><topic>Rabbits</topic><topic>Sodium Chloride - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holland, Robert C</creatorcontrib><creatorcontrib>Sundsten, John W</creatorcontrib><creatorcontrib>Sawyer, Charles H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holland, Robert C</au><au>Sundsten, John W</au><au>Sawyer, Charles H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Intracarotid Injections of Hypertonic Solutions on Arterial Pressure in the Rabbit</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1959-09</date><risdate>1959</risdate><volume>7</volume><issue>5</issue><spage>712</spage><epage>720</epage><pages>712-720</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>The intracarotid injection of hypertonic saline in the rabbit induces a brief drop in arterial pressure followed by a somewhat longer pressor phase. 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| ispartof | Circulation research, 1959-09, Vol.7 (5), p.712-720 |
| issn | 0009-7330 1524-4571 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Blood Pressure - pharmacology Hypertonic Solutions - pharmacology Injections Old Medline Pressure Rabbits Sodium Chloride - pharmacology |
| title | Effects of Intracarotid Injections of Hypertonic Solutions on Arterial Pressure in the Rabbit |
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