Effects of 6-hydroxydopamine on an identified dopamine-containing neuron in the central nervous system of Planorbis corneus
(1) A giant dopamine-containing cell (GDC) in the central nervous system of Planorbis corneus produces excitatory or inhibitory postsynaptic potentials in a number of different follower neurones; the potentials appear to be produced by direct connexions from the GDC and to result from release of dop...
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| Veröffentlicht in: | Brain research 1974-08, Vol.76 (2), p.309-324 |
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| container_title | Brain research |
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| creator | Berry, M.S. Pentreath, V.W. Turner, J.D. Cottrell, G.A. |
| description | (1)
A giant dopamine-containing cell (GDC) in the central nervous system of
Planorbis corneus produces excitatory or inhibitory postsynaptic potentials in a number of different follower neurones; the potentials appear to be produced by direct connexions from the GDC and to result from release of dopamine. The effects of bathing the isolated central nervous system in 6-hydroxydopamine (6-OHDA) were observed on the GDC and on transmission from it.
(2)
6-OHDA produced a postsynaptic blockade of transmission from the GDC by blocking the dopamine receptors of the follower neurones. The action was specific and more effective for inhibitory transmission than excitatory; it was reversible up to about 1 h exposure to 6-OHDA.
(3)
6-OHDA caused an increase in catecholamine-specific fluorescence in the GDC perikaryon. No concomitant changes in ultrastructure were observed, although certain axon processes in areas of neuropile containing presynaptic endings of the GDC showed a marked increase in vesicle granulation, and subsequent degeneration. |
| doi_str_mv | 10.1016/0006-8993(74)90462-4 |
| format | Article |
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A giant dopamine-containing cell (GDC) in the central nervous system of
Planorbis corneus produces excitatory or inhibitory postsynaptic potentials in a number of different follower neurones; the potentials appear to be produced by direct connexions from the GDC and to result from release of dopamine. The effects of bathing the isolated central nervous system in 6-hydroxydopamine (6-OHDA) were observed on the GDC and on transmission from it.
(2)
6-OHDA produced a postsynaptic blockade of transmission from the GDC by blocking the dopamine receptors of the follower neurones. The action was specific and more effective for inhibitory transmission than excitatory; it was reversible up to about 1 h exposure to 6-OHDA.
(3)
6-OHDA caused an increase in catecholamine-specific fluorescence in the GDC perikaryon. No concomitant changes in ultrastructure were observed, although certain axon processes in areas of neuropile containing presynaptic endings of the GDC showed a marked increase in vesicle granulation, and subsequent degeneration.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(74)90462-4</identifier><identifier>PMID: 4367507</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Central Nervous System - drug effects ; Dopamine ; Esophagus - innervation ; Ganglia - drug effects ; Hydroxydopamines - pharmacology ; Microscopy, Electron ; Microscopy, Fluorescence ; Neural Inhibition - drug effects ; Neurons - drug effects ; Receptors, Adrenergic - drug effects ; Receptors, Cholinergic - drug effects ; Snails - drug effects ; Synaptic Transmission - drug effects</subject><ispartof>Brain research, 1974-08, Vol.76 (2), p.309-324</ispartof><rights>1974 Elsevier Scientific Publishing Company, Amsterdam</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(74)90462-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27913,27914,45984</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4367507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berry, M.S.</creatorcontrib><creatorcontrib>Pentreath, V.W.</creatorcontrib><creatorcontrib>Turner, J.D.</creatorcontrib><creatorcontrib>Cottrell, G.A.</creatorcontrib><title>Effects of 6-hydroxydopamine on an identified dopamine-containing neuron in the central nervous system of Planorbis corneus</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>(1)
A giant dopamine-containing cell (GDC) in the central nervous system of
Planorbis corneus produces excitatory or inhibitory postsynaptic potentials in a number of different follower neurones; the potentials appear to be produced by direct connexions from the GDC and to result from release of dopamine. The effects of bathing the isolated central nervous system in 6-hydroxydopamine (6-OHDA) were observed on the GDC and on transmission from it.
(2)
6-OHDA produced a postsynaptic blockade of transmission from the GDC by blocking the dopamine receptors of the follower neurones. The action was specific and more effective for inhibitory transmission than excitatory; it was reversible up to about 1 h exposure to 6-OHDA.
(3)
6-OHDA caused an increase in catecholamine-specific fluorescence in the GDC perikaryon. No concomitant changes in ultrastructure were observed, although certain axon processes in areas of neuropile containing presynaptic endings of the GDC showed a marked increase in vesicle granulation, and subsequent degeneration.</description><subject>Animals</subject><subject>Central Nervous System - drug effects</subject><subject>Dopamine</subject><subject>Esophagus - innervation</subject><subject>Ganglia - drug effects</subject><subject>Hydroxydopamines - pharmacology</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Fluorescence</subject><subject>Neural Inhibition - drug effects</subject><subject>Neurons - drug effects</subject><subject>Receptors, Adrenergic - drug effects</subject><subject>Receptors, Cholinergic - drug effects</subject><subject>Snails - drug effects</subject><subject>Synaptic Transmission - drug effects</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UctOxCAUJUaj4-MPNGFldFEFykC7MTETX4mJLnRNKL04mCmM0Bon_rzUGV3dcM8jh3MROqbkghIqLgkhoqjqujyT_LwmXLCCb6EJrSQrBONkG03-KXtoP6X3_CzLmuyiXV4KOSVygr5vrAXTJxwsFsV81cbwtWrDUnfOAw4ea49dC7531kGL_5DCBN9r551_wx6GmInO434O2GRu1Iu8jZ9hSDitUg_daP-80D7ExiVsQsyidIh2rF4kONrMA_R6e_Myuy8en-4eZtePBTBB-wJEBaQqqZSyqdl0SkFaK3UjDJNTU7aSS0Mtk1bUTWMq05j8S8FYxYXOMl4eoNO17zKGjwFSrzqXDCxyHsgRVcU4HwWZeLIhDk0HrVpG1-m4Upu2Mn61xiGn_XQQVTIOvIHWxVyiaoNTlKjxOmqsXo3VK8nV73WyzQ9UWIJl</recordid><startdate>19740816</startdate><enddate>19740816</enddate><creator>Berry, M.S.</creator><creator>Pentreath, V.W.</creator><creator>Turner, J.D.</creator><creator>Cottrell, G.A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19740816</creationdate><title>Effects of 6-hydroxydopamine on an identified dopamine-containing neuron in the central nervous system of Planorbis corneus</title><author>Berry, M.S. ; Pentreath, V.W. ; Turner, J.D. ; Cottrell, G.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e261t-e68e0831777b92551e7ff7ab6c275c3d747c1f27f69bbc8cbc033622846a83143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Central Nervous System - drug effects</topic><topic>Dopamine</topic><topic>Esophagus - innervation</topic><topic>Ganglia - drug effects</topic><topic>Hydroxydopamines - pharmacology</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Fluorescence</topic><topic>Neural Inhibition - drug effects</topic><topic>Neurons - drug effects</topic><topic>Receptors, Adrenergic - drug effects</topic><topic>Receptors, Cholinergic - drug effects</topic><topic>Snails - drug effects</topic><topic>Synaptic Transmission - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berry, M.S.</creatorcontrib><creatorcontrib>Pentreath, V.W.</creatorcontrib><creatorcontrib>Turner, J.D.</creatorcontrib><creatorcontrib>Cottrell, G.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berry, M.S.</au><au>Pentreath, V.W.</au><au>Turner, J.D.</au><au>Cottrell, G.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 6-hydroxydopamine on an identified dopamine-containing neuron in the central nervous system of Planorbis corneus</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1974-08-16</date><risdate>1974</risdate><volume>76</volume><issue>2</issue><spage>309</spage><epage>324</epage><pages>309-324</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>(1)
A giant dopamine-containing cell (GDC) in the central nervous system of
Planorbis corneus produces excitatory or inhibitory postsynaptic potentials in a number of different follower neurones; the potentials appear to be produced by direct connexions from the GDC and to result from release of dopamine. The effects of bathing the isolated central nervous system in 6-hydroxydopamine (6-OHDA) were observed on the GDC and on transmission from it.
(2)
6-OHDA produced a postsynaptic blockade of transmission from the GDC by blocking the dopamine receptors of the follower neurones. The action was specific and more effective for inhibitory transmission than excitatory; it was reversible up to about 1 h exposure to 6-OHDA.
(3)
6-OHDA caused an increase in catecholamine-specific fluorescence in the GDC perikaryon. No concomitant changes in ultrastructure were observed, although certain axon processes in areas of neuropile containing presynaptic endings of the GDC showed a marked increase in vesicle granulation, and subsequent degeneration.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4367507</pmid><doi>10.1016/0006-8993(74)90462-4</doi><tpages>16</tpages></addata></record> |
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| ispartof | Brain research, 1974-08, Vol.76 (2), p.309-324 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Central Nervous System - drug effects Dopamine Esophagus - innervation Ganglia - drug effects Hydroxydopamines - pharmacology Microscopy, Electron Microscopy, Fluorescence Neural Inhibition - drug effects Neurons - drug effects Receptors, Adrenergic - drug effects Receptors, Cholinergic - drug effects Snails - drug effects Synaptic Transmission - drug effects |
| title | Effects of 6-hydroxydopamine on an identified dopamine-containing neuron in the central nervous system of Planorbis corneus |
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