SOME SEROLOGIC ASPECTS OF THE IMMUNE RESPONSE IN THE ATLANTIC BOTTLE-NOSED PORPOISE
An investigation of the immunologic responsiveness of Tursiops truncatus to Erysipelothrix insidiosa and Clostridium perfringens Type D antigens was reported. Serum protein changes were recorded by electrophoresis, and the induction time, degree and duration of the immune response were determined by...
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| Veröffentlicht in: | Journal of wildlife diseases 1974-07, Vol.10 (3), p.180-186 |
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| container_end_page | 186 |
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| container_issue | 3 |
| container_start_page | 180 |
| container_title | Journal of wildlife diseases |
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| creator | GRAY, KENNETH N. KLONTZ, GEORGE W. |
| description | An investigation of the immunologic responsiveness of Tursiops truncatus to Erysipelothrix insidiosa and Clostridium perfringens Type D antigens was reported. Serum protein changes were recorded by electrophoresis, and the induction time, degree and duration of the immune response were determined by immunofluorescence. Passive protection studies were conducted in mice using porpoise serum dilutions and an LD50 of E. insidiosa and a TD50 of the epsilon toxin of Cl. perfringens Type D. Statistically significant quantitative changes in beta-2 globulins were observed in T. truncatus following inoculation with either E. insidiosa bacterin or Cl. perfringens Type D bacterin-toxoid. Newly captured T. truncatus possessed circulating antibodies to E. insidiosa and Cl. perfringens Type D; these antibodies were demonstrated using indirect immunofluorescence. Serum from T. truncatus having a 1:1024 titer to E. insidiosa prevented the development of clinical signs of disease and bacteremia produced by an LD50 of E. insidiosa in mice. |
| doi_str_mv | 10.7589/0090-3558-10.3.180 |
| format | Article |
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Serum protein changes were recorded by electrophoresis, and the induction time, degree and duration of the immune response were determined by immunofluorescence. Passive protection studies were conducted in mice using porpoise serum dilutions and an LD50 of E. insidiosa and a TD50 of the epsilon toxin of Cl. perfringens Type D. Statistically significant quantitative changes in beta-2 globulins were observed in T. truncatus following inoculation with either E. insidiosa bacterin or Cl. perfringens Type D bacterin-toxoid. Newly captured T. truncatus possessed circulating antibodies to E. insidiosa and Cl. perfringens Type D; these antibodies were demonstrated using indirect immunofluorescence. Serum from T. truncatus having a 1:1024 titer to E. insidiosa prevented the development of clinical signs of disease and bacteremia produced by an LD50 of E. insidiosa in mice.</description><identifier>ISSN: 0090-3558</identifier><identifier>EISSN: 1943-3700</identifier><identifier>DOI: 10.7589/0090-3558-10.3.180</identifier><identifier>PMID: 4135930</identifier><language>eng</language><publisher>United States: Wildlife Disease Association</publisher><subject>Animals ; Antibody Formation ; Antigens, Bacterial - administration & dosage ; Beta-Globulins - analysis ; Blood Proteins - analysis ; Clostridium perfringens - immunology ; Dolphins - immunology ; Erysipelothrix - immunology ; Fluorescent Antibody Technique ; Immunization, Passive ; Injections, Subcutaneous ; Mice</subject><ispartof>Journal of wildlife diseases, 1974-07, Vol.10 (3), p.180-186</ispartof><rights>1974 Wildlife Disease Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b254t-eca2c3abc39a5171d72db7ba2e7c981182f47a95ffbfa58ded91a8ff3d6224083</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.7589/0090-3558-10.3.180$$EPDF$$P50$$Gbioone$$H</linktopdf><link.rule.ids>109,314,777,781,27905,27906,52700</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4135930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GRAY, KENNETH N.</creatorcontrib><creatorcontrib>KLONTZ, GEORGE W.</creatorcontrib><title>SOME SEROLOGIC ASPECTS OF THE IMMUNE RESPONSE IN THE ATLANTIC BOTTLE-NOSED PORPOISE</title><title>Journal of wildlife diseases</title><addtitle>J Wildl Dis</addtitle><description>An investigation of the immunologic responsiveness of Tursiops truncatus to Erysipelothrix insidiosa and Clostridium perfringens Type D antigens was reported. Serum protein changes were recorded by electrophoresis, and the induction time, degree and duration of the immune response were determined by immunofluorescence. Passive protection studies were conducted in mice using porpoise serum dilutions and an LD50 of E. insidiosa and a TD50 of the epsilon toxin of Cl. perfringens Type D. Statistically significant quantitative changes in beta-2 globulins were observed in T. truncatus following inoculation with either E. insidiosa bacterin or Cl. perfringens Type D bacterin-toxoid. Newly captured T. truncatus possessed circulating antibodies to E. insidiosa and Cl. perfringens Type D; these antibodies were demonstrated using indirect immunofluorescence. Serum from T. truncatus having a 1:1024 titer to E. insidiosa prevented the development of clinical signs of disease and bacteremia produced by an LD50 of E. insidiosa in mice.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>Antigens, Bacterial - administration & dosage</subject><subject>Beta-Globulins - analysis</subject><subject>Blood Proteins - analysis</subject><subject>Clostridium perfringens - immunology</subject><subject>Dolphins - immunology</subject><subject>Erysipelothrix - immunology</subject><subject>Fluorescent Antibody Technique</subject><subject>Immunization, Passive</subject><subject>Injections, Subcutaneous</subject><subject>Mice</subject><issn>0090-3558</issn><issn>1943-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF9PwjAUxRujQUS_gInJnnwb9s_q2seJRUjGutDx3HRbl2CA4QoPfns7IDz7dHPPOffc5AfAM4LjmDL-BiGHIaGUhV4hY8TgDRgiHpGQxBDeguE1cA8enPuGEFO_DMAgQoRyAodAKbkQgRJLmcqv-SRIVC4mhQrkNChmIpgvFqtMBEuhcpkpv2cnOSnSJCt8_EMWRSrCTCrxGeRymcu5Eo_grjEbZ58ucwRWU1FMZuHpRZKGJabRIbSVwRUxZUW4oShGdYzrMi4NtnHFGUIMN1FsOG2asjGU1bbmyLCmIfU7xhFkZARez737rv05WnfQ27Wr7GZjdrY9Os1wRCDisQ_ic7DqWuc62-h9t96a7lcjqHuSugele1C9QrQn6Y9eLu3Hcmvr68kFnffh2S_Xbbuz_6n8A1X-da0</recordid><startdate>197407</startdate><enddate>197407</enddate><creator>GRAY, KENNETH N.</creator><creator>KLONTZ, GEORGE W.</creator><general>Wildlife Disease Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197407</creationdate><title>SOME SEROLOGIC ASPECTS OF THE IMMUNE RESPONSE IN THE ATLANTIC BOTTLE-NOSED PORPOISE</title><author>GRAY, KENNETH N. ; KLONTZ, GEORGE W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b254t-eca2c3abc39a5171d72db7ba2e7c981182f47a95ffbfa58ded91a8ff3d6224083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>Antigens, Bacterial - administration & dosage</topic><topic>Beta-Globulins - analysis</topic><topic>Blood Proteins - analysis</topic><topic>Clostridium perfringens - immunology</topic><topic>Dolphins - immunology</topic><topic>Erysipelothrix - immunology</topic><topic>Fluorescent Antibody Technique</topic><topic>Immunization, Passive</topic><topic>Injections, Subcutaneous</topic><topic>Mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GRAY, KENNETH N.</creatorcontrib><creatorcontrib>KLONTZ, GEORGE W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of wildlife diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GRAY, KENNETH N.</au><au>KLONTZ, GEORGE W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SOME SEROLOGIC ASPECTS OF THE IMMUNE RESPONSE IN THE ATLANTIC BOTTLE-NOSED PORPOISE</atitle><jtitle>Journal of wildlife diseases</jtitle><addtitle>J Wildl Dis</addtitle><date>1974-07</date><risdate>1974</risdate><volume>10</volume><issue>3</issue><spage>180</spage><epage>186</epage><pages>180-186</pages><issn>0090-3558</issn><eissn>1943-3700</eissn><abstract>An investigation of the immunologic responsiveness of Tursiops truncatus to Erysipelothrix insidiosa and Clostridium perfringens Type D antigens was reported. Serum protein changes were recorded by electrophoresis, and the induction time, degree and duration of the immune response were determined by immunofluorescence. Passive protection studies were conducted in mice using porpoise serum dilutions and an LD50 of E. insidiosa and a TD50 of the epsilon toxin of Cl. perfringens Type D. Statistically significant quantitative changes in beta-2 globulins were observed in T. truncatus following inoculation with either E. insidiosa bacterin or Cl. perfringens Type D bacterin-toxoid. Newly captured T. truncatus possessed circulating antibodies to E. insidiosa and Cl. perfringens Type D; these antibodies were demonstrated using indirect immunofluorescence. Serum from T. truncatus having a 1:1024 titer to E. insidiosa prevented the development of clinical signs of disease and bacteremia produced by an LD50 of E. insidiosa in mice.</abstract><cop>United States</cop><pub>Wildlife Disease Association</pub><pmid>4135930</pmid><doi>10.7589/0090-3558-10.3.180</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-3558 |
| ispartof | Journal of wildlife diseases, 1974-07, Vol.10 (3), p.180-186 |
| issn | 0090-3558 1943-3700 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82430197 |
| source | MEDLINE; BioOne Open Access Titles; Allen Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antibody Formation Antigens, Bacterial - administration & dosage Beta-Globulins - analysis Blood Proteins - analysis Clostridium perfringens - immunology Dolphins - immunology Erysipelothrix - immunology Fluorescent Antibody Technique Immunization, Passive Injections, Subcutaneous Mice |
| title | SOME SEROLOGIC ASPECTS OF THE IMMUNE RESPONSE IN THE ATLANTIC BOTTLE-NOSED PORPOISE |
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