Laboratory Evaluation of Amoxicillin
Amoxicillin (α-amino-p-hydroxybenzylpenicillin) is a new semisynthetic penicillin structurally related to ampicillin. The antibacterial spectrum of amoxicillin includes streptococci, pneumococci, penicillin-sensitive staphylococci, Haemophilus infiuenzae, Neisseria meningitidis, Neisseria gonorrhoea...
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| Veröffentlicht in: | The Journal of infectious diseases 1974-06, Vol.129 (Supplement-2), p.S139-S145 |
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| container_issue | Supplement-2 |
| container_start_page | S139 |
| container_title | The Journal of infectious diseases |
| container_volume | 129 |
| creator | Rolinson, G. N. |
| description | Amoxicillin (α-amino-p-hydroxybenzylpenicillin) is a new semisynthetic penicillin structurally related to ampicillin. The antibacterial spectrum of amoxicillin includes streptococci, pneumococci, penicillin-sensitive staphylococci, Haemophilus infiuenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli, Proteus mirabilis, and Salmonella species. The level of activity of amoxicillin is generally similar to that of ampicillin. Amoxicillin is more active than ampicillin against experimental infections of mice with gram-positive and gram-negative bacteria. The superior in vivo activity of amoxicillin cannot be explained solely on the basis of increased oral absorption. Bactericidal action measured in a mouse thigh infection model is more rapid with amoxicillin. Blood levels of amoxicillin in man are twice those achieved with equivalent doses of ampicillin. Peak serum concentrations are proportional to the dose, and 58%–68% of a dose is recovered unchanged in the urine. Absorption of amoxicillin is not greatly influenced by the presence of food. As with other orally-administered penicillins, higher and more prolonged levels of amoxicillin in blood are obtained when probenecid is used. |
| doi_str_mv | 10.1093/infdis/129.Supplement_2.S139 |
| format | Article |
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N.</creator><creatorcontrib>Rolinson, G. N.</creatorcontrib><description>Amoxicillin (α-amino-p-hydroxybenzylpenicillin) is a new semisynthetic penicillin structurally related to ampicillin. The antibacterial spectrum of amoxicillin includes streptococci, pneumococci, penicillin-sensitive staphylococci, Haemophilus infiuenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli, Proteus mirabilis, and Salmonella species. The level of activity of amoxicillin is generally similar to that of ampicillin. Amoxicillin is more active than ampicillin against experimental infections of mice with gram-positive and gram-negative bacteria. The superior in vivo activity of amoxicillin cannot be explained solely on the basis of increased oral absorption. Bactericidal action measured in a mouse thigh infection model is more rapid with amoxicillin. Blood levels of amoxicillin in man are twice those achieved with equivalent doses of ampicillin. Peak serum concentrations are proportional to the dose, and 58%–68% of a dose is recovered unchanged in the urine. Absorption of amoxicillin is not greatly influenced by the presence of food. As with other orally-administered penicillins, higher and more prolonged levels of amoxicillin in blood are obtained when probenecid is used.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/129.Supplement_2.S139</identifier><identifier>PMID: 4601188</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Administration, Oral ; Amines - administration & dosage ; Amines - metabolism ; Amines - pharmacology ; Amines - therapeutic use ; Amines - urine ; Ampicillin - administration & dosage ; Ampicillin - blood ; Ampicillin - therapeutic use ; Ampicillin - urine ; Animals ; Antibacterials ; Bacteria - drug effects ; Blood ; Dosage ; Dose-Response Relationship, Drug ; Escherichia coli ; Escherichia coli Infections - drug therapy ; Fasting ; Food ; Human resources ; Humans ; Infant, Newborn ; Infections ; Injections, Subcutaneous ; Intestinal Absorption ; Klebsiella Infections - drug therapy ; Mice ; Neisseria gonorrhoeae ; Penicillin ; Penicillin Resistance ; Penicillinase - pharmacology ; Penicillins - administration & dosage ; Penicillins - blood ; Penicillins - metabolism ; Penicillins - pharmacology ; Penicillins - therapeutic use ; Penicillins - urine ; Probenecid - pharmacology ; Protein Binding ; Session I. In Vitro Activity and Human Pharcology of Amoxicillin ; Staphylococcus ; Urine</subject><ispartof>The Journal of infectious diseases, 1974-06, Vol.129 (Supplement-2), p.S139-S145</ispartof><rights>Copyright 1974 University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-47aee368fd7ea5ab0285957933012ce6d5e6a8167127dc9654a5d7eaf59465893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30105968$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30105968$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4601188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rolinson, G. N.</creatorcontrib><title>Laboratory Evaluation of Amoxicillin</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Amoxicillin (α-amino-p-hydroxybenzylpenicillin) is a new semisynthetic penicillin structurally related to ampicillin. The antibacterial spectrum of amoxicillin includes streptococci, pneumococci, penicillin-sensitive staphylococci, Haemophilus infiuenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli, Proteus mirabilis, and Salmonella species. The level of activity of amoxicillin is generally similar to that of ampicillin. Amoxicillin is more active than ampicillin against experimental infections of mice with gram-positive and gram-negative bacteria. The superior in vivo activity of amoxicillin cannot be explained solely on the basis of increased oral absorption. Bactericidal action measured in a mouse thigh infection model is more rapid with amoxicillin. Blood levels of amoxicillin in man are twice those achieved with equivalent doses of ampicillin. Peak serum concentrations are proportional to the dose, and 58%–68% of a dose is recovered unchanged in the urine. Absorption of amoxicillin is not greatly influenced by the presence of food. As with other orally-administered penicillins, higher and more prolonged levels of amoxicillin in blood are obtained when probenecid is used.</description><subject>Administration, Oral</subject><subject>Amines - administration & dosage</subject><subject>Amines - metabolism</subject><subject>Amines - pharmacology</subject><subject>Amines - therapeutic use</subject><subject>Amines - urine</subject><subject>Ampicillin - administration & dosage</subject><subject>Ampicillin - blood</subject><subject>Ampicillin - therapeutic use</subject><subject>Ampicillin - urine</subject><subject>Animals</subject><subject>Antibacterials</subject><subject>Bacteria - drug effects</subject><subject>Blood</subject><subject>Dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - drug therapy</subject><subject>Fasting</subject><subject>Food</subject><subject>Human resources</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Injections, Subcutaneous</subject><subject>Intestinal Absorption</subject><subject>Klebsiella Infections - drug therapy</subject><subject>Mice</subject><subject>Neisseria gonorrhoeae</subject><subject>Penicillin</subject><subject>Penicillin Resistance</subject><subject>Penicillinase - pharmacology</subject><subject>Penicillins - administration & dosage</subject><subject>Penicillins - blood</subject><subject>Penicillins - metabolism</subject><subject>Penicillins - pharmacology</subject><subject>Penicillins - therapeutic use</subject><subject>Penicillins - urine</subject><subject>Probenecid - pharmacology</subject><subject>Protein Binding</subject><subject>Session I. In Vitro Activity and Human Pharcology of Amoxicillin</subject><subject>Staphylococcus</subject><subject>Urine</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtKw0AUhgdRaq0-gtBFcZd2LpkbuCmlF6Wg2AriZpgmE5iaZGImkfbtTUiprs7i-_9zOB8AIwTHCEoysXkSWz9BWI43dVGkJjN5pfB4g4i8AH1ECQ8YQ-QS9CHEOEBCymtw4_0eQhgSxnugFzKIkBB9MFrrnSt15crjcP6j01pX1uVDlwynmTvYyKapzW_BVaJTb-5OcwDeF_PtbBWsX5ZPs-k6iAjBVRBybQxhIom50VTvIBZUUi4JgQhHhsXUMC0Q4wjzOJKMhpq20YTKkFEhyQA8dHuL0n3Xxlcqsz4yaapz42qvBA5h2HzWBB-7YFQ670uTqKK0mS6PCkHVSlKdJNVIUv8lqVZSU78_3al3mYnP5ZOVP773jZgzbt6AVLKWBx23vjKHM9fll2KccKpWH59q8UaX9Bm_qi35BalSgNg</recordid><startdate>197406</startdate><enddate>197406</enddate><creator>Rolinson, G. N.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197406</creationdate><title>Laboratory Evaluation of Amoxicillin</title><author>Rolinson, G. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-47aee368fd7ea5ab0285957933012ce6d5e6a8167127dc9654a5d7eaf59465893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Administration, Oral</topic><topic>Amines - administration & dosage</topic><topic>Amines - metabolism</topic><topic>Amines - pharmacology</topic><topic>Amines - therapeutic use</topic><topic>Amines - urine</topic><topic>Ampicillin - administration & dosage</topic><topic>Ampicillin - blood</topic><topic>Ampicillin - therapeutic use</topic><topic>Ampicillin - urine</topic><topic>Animals</topic><topic>Antibacterials</topic><topic>Bacteria - drug effects</topic><topic>Blood</topic><topic>Dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Escherichia coli</topic><topic>Escherichia coli Infections - drug therapy</topic><topic>Fasting</topic><topic>Food</topic><topic>Human resources</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Injections, Subcutaneous</topic><topic>Intestinal Absorption</topic><topic>Klebsiella Infections - drug therapy</topic><topic>Mice</topic><topic>Neisseria gonorrhoeae</topic><topic>Penicillin</topic><topic>Penicillin Resistance</topic><topic>Penicillinase - pharmacology</topic><topic>Penicillins - administration & dosage</topic><topic>Penicillins - blood</topic><topic>Penicillins - metabolism</topic><topic>Penicillins - pharmacology</topic><topic>Penicillins - therapeutic use</topic><topic>Penicillins - urine</topic><topic>Probenecid - pharmacology</topic><topic>Protein Binding</topic><topic>Session I. In Vitro Activity and Human Pharcology of Amoxicillin</topic><topic>Staphylococcus</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rolinson, G. N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rolinson, G. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laboratory Evaluation of Amoxicillin</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1974-06</date><risdate>1974</risdate><volume>129</volume><issue>Supplement-2</issue><spage>S139</spage><epage>S145</epage><pages>S139-S145</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Amoxicillin (α-amino-p-hydroxybenzylpenicillin) is a new semisynthetic penicillin structurally related to ampicillin. The antibacterial spectrum of amoxicillin includes streptococci, pneumococci, penicillin-sensitive staphylococci, Haemophilus infiuenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli, Proteus mirabilis, and Salmonella species. The level of activity of amoxicillin is generally similar to that of ampicillin. Amoxicillin is more active than ampicillin against experimental infections of mice with gram-positive and gram-negative bacteria. The superior in vivo activity of amoxicillin cannot be explained solely on the basis of increased oral absorption. Bactericidal action measured in a mouse thigh infection model is more rapid with amoxicillin. Blood levels of amoxicillin in man are twice those achieved with equivalent doses of ampicillin. Peak serum concentrations are proportional to the dose, and 58%–68% of a dose is recovered unchanged in the urine. Absorption of amoxicillin is not greatly influenced by the presence of food. As with other orally-administered penicillins, higher and more prolonged levels of amoxicillin in blood are obtained when probenecid is used.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>4601188</pmid><doi>10.1093/infdis/129.Supplement_2.S139</doi></addata></record> |
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| ispartof | The Journal of infectious diseases, 1974-06, Vol.129 (Supplement-2), p.S139-S145 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82404613 |
| source | Jstor Complete Legacy; MEDLINE |
| subjects | Administration, Oral Amines - administration & dosage Amines - metabolism Amines - pharmacology Amines - therapeutic use Amines - urine Ampicillin - administration & dosage Ampicillin - blood Ampicillin - therapeutic use Ampicillin - urine Animals Antibacterials Bacteria - drug effects Blood Dosage Dose-Response Relationship, Drug Escherichia coli Escherichia coli Infections - drug therapy Fasting Food Human resources Humans Infant, Newborn Infections Injections, Subcutaneous Intestinal Absorption Klebsiella Infections - drug therapy Mice Neisseria gonorrhoeae Penicillin Penicillin Resistance Penicillinase - pharmacology Penicillins - administration & dosage Penicillins - blood Penicillins - metabolism Penicillins - pharmacology Penicillins - therapeutic use Penicillins - urine Probenecid - pharmacology Protein Binding Session I. In Vitro Activity and Human Pharcology of Amoxicillin Staphylococcus Urine |
| title | Laboratory Evaluation of Amoxicillin |
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