Intestinal Motor Effects of a Unique Analgesic Agent

The effects of 2,3,5,6,11,11b-hexahydro-11,11b-dimethyl-14-indolizino(8,7,b)indole hydrochloride on intestinal motility were investigated. The indole derivative altered contractile activity in each preparation studied. Intestinal contractions in situ in anesthetized dogs were stimulated, but variabl...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1974-05, Vol.63 (5), p.787-790
Hauptverfasser:	Jacobs, Gary R., Burks, Thomas F.
Format:	Artikel
Sprache:	eng
Schlagworte:	11b-dimethyl-14-indolizino 11b-Hexahydro-11 2,3,5,6,11,11b-Hexahydro-11,11b-dimethyl-14-indolizino(8,7,b)indole hydrochloride—intestinal motor effects studied in cats, dogs, and monkeys 2,3,5,6,11,11b‐Hexahydro‐11,11b‐dimethyl‐14‐indolizino(8,7, b)indole hydrochloride—intestinal motor effects studied in cats, dogs, and monkeyss Analgesics Analgesics - pharmacology Analgesics, investigational indolazinoindole—effects on intestinal motility investigated and monkeys and monkeyss Animals b)indole hydrochloride-intestinal motor effects studied in cats Cats Dogs Dose-Response Relationship, Drug Gastrointestinal Motility - drug effects Haplorhini In Vitro Techniques Indole derivatives-intestinal motility effects of investigational indolazinoindole studied in cats Indole derivatives—intestinal motility effects of investigational indolazinoindole studied in cats, dogs, and monkeys Indoles - pharmacology Intestinal motility —effects of indolazinoindole analgesic in cats, dogs, and monkeys Intestinal motility-effects of indolazinoindole analgesic in cats investigational indolazinoindole-effects on intestinal motility investigated Macaca Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Species Specificity
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