Effect of Corticosterone and Cortisol on Corticosteroidogenesis in Isolated Rat Adrenal Cells
Isolated rat adrenal cells were incubated with corticosterone or cortisol in the presence of ACTH. When the corticosterone production in the absence of exogenous corticoids was taken as 100%, it was decreased to 77±3 and 62±4% by the addition of 1.0 and 2.0 μg of corticosterone to 1ml of incubation...
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| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1974, Vol.112(2), pp.195-196 |
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| container_title | The Tohoku Journal of Experimental Medicine |
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| creator | ABE, KIICHIRO HIROSE, TAEKO |
| description | Isolated rat adrenal cells were incubated with corticosterone or cortisol in the presence of ACTH. When the corticosterone production in the absence of exogenous corticoids was taken as 100%, it was decreased to 77±3 and 62±4% by the addition of 1.0 and 2.0 μg of corticosterone to 1ml of incubation medium, respectively. However, the same concentration of cortisol did not show any inhibitory effect on corticosterone production. |
| doi_str_mv | 10.1620/tjem.112.195 |
| format | Article |
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However, the same concentration of cortisol did not show any inhibitory effect on corticosterone production.</description><subject>Adrenal Cortex Hormones - biosynthesis</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Animals</subject><subject>Corticosterone - pharmacology</subject><subject>Depression, Chemical</subject><subject>Feedback</subject><subject>Hydrocortisone - pharmacology</subject><subject>In Vitro Techniques</subject><subject>isolated rat adrenal cell</subject><subject>Male</subject><subject>negative feedback at the adrenal level</subject><subject>negative feedback on corticosteroidogenesis</subject><subject>Rats</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMFLwzAYR4MoOqc3r0JOnuxMmqRLj6M4FQaC6FFCmnzRjq6ZSXbwvzdzc-Algfwej_AQuqJkQquS3KUlrCaUlhNaiyM0oozXBWNlfYxGhHBSyGk5PUPnMS4JYZxMq1N0ylklqBAj9H7vHJiEvcOND6kzPiYIfgCsB7t7ir7Hfvg3d9Z_wACxi7gb8FMmdAKLX3TCMxtg0D1uoO_jBTpxuo9wub_H6G1-_9o8Fovnh6dmtiiMoDQVxhLQWraghQQu21IzTh03ljNB2tJIV8FUECEJA9nSljrKLLhKVlpwK0s2Rjc77zr4rw3EpFZdNPkHegC_iSojNSWMZPB2B5rgYwzg1Dp0Kx2-FSVqW1Nta6pcU-WaGb_eezftCuwB3ufL-3y3L2PSH3DY9TZVD78yWmfrVlj-nbU4AOZTBwUD-wH23opK</recordid><startdate>19740101</startdate><enddate>19740101</enddate><creator>ABE, KIICHIRO</creator><creator>HIROSE, TAEKO</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19740101</creationdate><title>Effect of Corticosterone and Cortisol on Corticosteroidogenesis in Isolated Rat Adrenal Cells</title><author>ABE, KIICHIRO ; HIROSE, TAEKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-cd0eaa8bea58e48b2a341f4cd4350b2c8f6e7505803e8b1b1f13def686a54d823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adrenal Cortex Hormones - biosynthesis</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Animals</topic><topic>Corticosterone - pharmacology</topic><topic>Depression, Chemical</topic><topic>Feedback</topic><topic>Hydrocortisone - pharmacology</topic><topic>In Vitro Techniques</topic><topic>isolated rat adrenal cell</topic><topic>Male</topic><topic>negative feedback at the adrenal level</topic><topic>negative feedback on corticosteroidogenesis</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ABE, KIICHIRO</creatorcontrib><creatorcontrib>HIROSE, TAEKO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ABE, KIICHIRO</au><au>HIROSE, TAEKO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Corticosterone and Cortisol on Corticosteroidogenesis in Isolated Rat Adrenal Cells</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. Exp. Med.</addtitle><date>1974-01-01</date><risdate>1974</risdate><volume>112</volume><issue>2</issue><spage>195</spage><epage>196</epage><pages>195-196</pages><issn>0040-8727</issn><eissn>1349-3329</eissn><abstract>Isolated rat adrenal cells were incubated with corticosterone or cortisol in the presence of ACTH. When the corticosterone production in the absence of exogenous corticoids was taken as 100%, it was decreased to 77±3 and 62±4% by the addition of 1.0 and 2.0 μg of corticosterone to 1ml of incubation medium, respectively. However, the same concentration of cortisol did not show any inhibitory effect on corticosterone production.</abstract><cop>Japan</cop><pub>Tohoku University Medical Press</pub><pmid>4365155</pmid><doi>10.1620/tjem.112.195</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Tohoku Journal of Experimental Medicine, 1974, Vol.112(2), pp.195-196 |
| issn | 0040-8727 1349-3329 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82391030 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adrenal Cortex Hormones - biosynthesis Adrenal Glands - metabolism Adrenocorticotropic Hormone - pharmacology Animals Corticosterone - pharmacology Depression, Chemical Feedback Hydrocortisone - pharmacology In Vitro Techniques isolated rat adrenal cell Male negative feedback at the adrenal level negative feedback on corticosteroidogenesis Rats |
| title | Effect of Corticosterone and Cortisol on Corticosteroidogenesis in Isolated Rat Adrenal Cells |
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