The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture
In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1974-04, Vol.71 (4), p.1133-1136 |
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| container_end_page | 1136 |
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| container_issue | 4 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 71 |
| creator | Halpern, Barbara C. Clark, Brian R. Hardy, Dorothy N. Halpern, Richard M. Smith, Roberts A. |
| description | In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die. |
| doi_str_mv | 10.1073/pnas.71.4.1133 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1974-04, Vol.71 (4), p.1133-1136 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82367225 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adults Animals Biological Sciences: Cell Biology Breast Carcinoma 256, Walker - metabolism Cell culture techniques Cell Division - drug effects Cell growth Cell Line Cell lines Cell Survival Cells Cells, Cultured - metabolism Culture Media Cultured cells Female Fibroblasts Folic Acid - metabolism Homocystine - metabolism Humans Leukemia Leukemia L1210 Leukemia, Experimental Leukemia, Myeloid Liver Male Methionine - metabolism Mice Prostate Rats Tissue culture techniques Vitamin B 12 - metabolism Vitamin B12 |
| title | The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture |
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