Patterns of Hemopoietic Recovery in Irradiated Mice
We have demonstrated three distinct patterns of altered hemopoietic recovery in irradiated mice: 1. That seen in mice given isologous hemopoietic cells, in which granulocytes, lymphocytes, hemoglobin and platelets all showed an early recovery The time required for granulocyte and lymphocyte recovery...
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| Veröffentlicht in: | Blood 1959-06, Vol.14 (6), p.737-747 |
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| creator | Smith, Willie W. and, Robert Q. Marston Cornfield, Jerome Alderman, Ilo M. and, Ruth E. Gillespie Ruth, H. Jeanette |
| description | We have demonstrated three distinct patterns of altered hemopoietic recovery in irradiated mice:
1. That seen in mice given isologous hemopoietic cells, in which granulocytes, lymphocytes, hemoglobin and platelets all showed an early recovery The time required for granulocyte and lymphocyte recovery was relatively unaffected by the amount of radiation to which the host was exposed (LD1-99). The time between injection and recovery was also relatively constant.
2. That seen in mice given rat bone marrow, in which only granulocytes and hemoglobin showed an early increase in concentration, with lymphocytes and platelets recovering near the control times.
3. That seen in mice given endotoxin or colchicine prior to irradiation in which the lymphocyte recovery was variable while the granulocytes, hemoglobin and platelets compared favorably with mice given isologous bone marrow. |
| doi_str_mv | 10.1182/blood.V14.6.737.737 |
| format | Article |
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1. That seen in mice given isologous hemopoietic cells, in which granulocytes, lymphocytes, hemoglobin and platelets all showed an early recovery The time required for granulocyte and lymphocyte recovery was relatively unaffected by the amount of radiation to which the host was exposed (LD1-99). The time between injection and recovery was also relatively constant.
2. That seen in mice given rat bone marrow, in which only granulocytes and hemoglobin showed an early increase in concentration, with lymphocytes and platelets recovering near the control times.
3. That seen in mice given endotoxin or colchicine prior to irradiation in which the lymphocyte recovery was variable while the granulocytes, hemoglobin and platelets compared favorably with mice given isologous bone marrow.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V14.6.737.737</identifier><identifier>PMID: 13651345</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Hematopoietic System - radiation effects ; Mice ; Old Medline ; Radiation ; X-Rays</subject><ispartof>Blood, 1959-06, Vol.14 (6), p.737-747</ispartof><rights>1959 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-cafe1efda99d1863d295ea1b48496e597dc3842bccac62f9441360cbd89ed4d53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13651345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Willie W.</creatorcontrib><creatorcontrib>and, Robert Q. Marston</creatorcontrib><creatorcontrib>Cornfield, Jerome</creatorcontrib><creatorcontrib>Alderman, Ilo M.</creatorcontrib><creatorcontrib>and, Ruth E. Gillespie</creatorcontrib><creatorcontrib>Ruth, H. Jeanette</creatorcontrib><title>Patterns of Hemopoietic Recovery in Irradiated Mice</title><title>Blood</title><addtitle>Blood</addtitle><description>We have demonstrated three distinct patterns of altered hemopoietic recovery in irradiated mice:
1. That seen in mice given isologous hemopoietic cells, in which granulocytes, lymphocytes, hemoglobin and platelets all showed an early recovery The time required for granulocyte and lymphocyte recovery was relatively unaffected by the amount of radiation to which the host was exposed (LD1-99). The time between injection and recovery was also relatively constant.
2. That seen in mice given rat bone marrow, in which only granulocytes and hemoglobin showed an early increase in concentration, with lymphocytes and platelets recovering near the control times.
3. That seen in mice given endotoxin or colchicine prior to irradiation in which the lymphocyte recovery was variable while the granulocytes, hemoglobin and platelets compared favorably with mice given isologous bone marrow.</description><subject>Animals</subject><subject>Hematopoietic System - radiation effects</subject><subject>Mice</subject><subject>Old Medline</subject><subject>Radiation</subject><subject>X-Rays</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1959</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9Lw0AQxRdRbK1-AkFy8pa4_5M9eBBRW6gool6Xze4EVpJs3U0L_famtuDNw2Mu772Z-SF0SXBBSEVv6jYEV3wSXsiiZOVOR2hKBK1yjCk-RlOMscy5KskEnaX0hTHhjIpTNCFMCsK4mCL2aoYBYp-y0GRz6MIqeBi8zd7Ahg3Ebeb7bBGjcd4M4LJnb-EcnTSmTXBxmDP08fjwfj_Ply9Pi_u7ZW45pkNuTQMEGmeUcqSSzFElwJCaV1xJEKp0llWc1tYaK2mjOB_PwrZ2lQLHnWAzdL3vXcXwvYY06M4nC21regjrpCvKRFVKPBrZ3mhjSClCo1fRdyZuNcF6x0r_stIjKy31yGmnMXV1qF_XHbi_zAHOaLjdG2B8cuMh6mQ99Bacj2AH7YL_d8EPtTN7Kg</recordid><startdate>19590601</startdate><enddate>19590601</enddate><creator>Smith, Willie W.</creator><creator>and, Robert Q. Marston</creator><creator>Cornfield, Jerome</creator><creator>Alderman, Ilo M.</creator><creator>and, Ruth E. Gillespie</creator><creator>Ruth, H. Jeanette</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19590601</creationdate><title>Patterns of Hemopoietic Recovery in Irradiated Mice</title><author>Smith, Willie W. ; and, Robert Q. Marston ; Cornfield, Jerome ; Alderman, Ilo M. ; and, Ruth E. Gillespie ; Ruth, H. Jeanette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-cafe1efda99d1863d295ea1b48496e597dc3842bccac62f9441360cbd89ed4d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1959</creationdate><topic>Animals</topic><topic>Hematopoietic System - radiation effects</topic><topic>Mice</topic><topic>Old Medline</topic><topic>Radiation</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Willie W.</creatorcontrib><creatorcontrib>and, Robert Q. Marston</creatorcontrib><creatorcontrib>Cornfield, Jerome</creatorcontrib><creatorcontrib>Alderman, Ilo M.</creatorcontrib><creatorcontrib>and, Ruth E. Gillespie</creatorcontrib><creatorcontrib>Ruth, H. Jeanette</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Willie W.</au><au>and, Robert Q. Marston</au><au>Cornfield, Jerome</au><au>Alderman, Ilo M.</au><au>and, Ruth E. Gillespie</au><au>Ruth, H. Jeanette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of Hemopoietic Recovery in Irradiated Mice</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1959-06-01</date><risdate>1959</risdate><volume>14</volume><issue>6</issue><spage>737</spage><epage>747</epage><pages>737-747</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>We have demonstrated three distinct patterns of altered hemopoietic recovery in irradiated mice:
1. That seen in mice given isologous hemopoietic cells, in which granulocytes, lymphocytes, hemoglobin and platelets all showed an early recovery The time required for granulocyte and lymphocyte recovery was relatively unaffected by the amount of radiation to which the host was exposed (LD1-99). The time between injection and recovery was also relatively constant.
2. That seen in mice given rat bone marrow, in which only granulocytes and hemoglobin showed an early increase in concentration, with lymphocytes and platelets recovering near the control times.
3. That seen in mice given endotoxin or colchicine prior to irradiation in which the lymphocyte recovery was variable while the granulocytes, hemoglobin and platelets compared favorably with mice given isologous bone marrow.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>13651345</pmid><doi>10.1182/blood.V14.6.737.737</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Animals Hematopoietic System - radiation effects Mice Old Medline Radiation X-Rays |
| title | Patterns of Hemopoietic Recovery in Irradiated Mice |
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