Kinetics and Clonal Restriction of the Anti-Dinitrophenyl Antibody Response to Dinitrophenyl-6-Amino-Caproyl-L-Tyrosine-Azobenzene-p-Arsonate in Guinea Pigs

The anti-DNP responses in guinea pigs to the small bifunctional antigen DNP-SAC-RAT and to DNP-protein were compared. The response to DNP-SAC-RAT is more restricted both in terms of the anti-DNP titers reached in serum and of the number of DNP specific clones expressed. Priming with DNP-SAC-RAT led...

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Veröffentlicht in:	The Journal of immunology (1950) 1974-03, Vol.112 (3), p.883-889
Hauptverfasser:	Roelants, Georges E, Goodman, Joel W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - analysis Antibody Formation Antibody-Producing Cells - immunology Arsenicals Autoradiography Azo Compounds Cattle - immunology Clone Cells Dipeptides gamma-Globulins Guinea Pigs Hemocyanins Immunization, Secondary Iodine Radioisotopes Isoelectric Focusing Kinetics Myeloma Proteins - analysis Nitrobenzenes Staining and Labeling
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