Products of Activated Lymphocytes: Leukocyte Inhibitory Factor (LIF) Distinct from Migration Inhibitory Factor (MIF)
The mechanism of inhibition in the leukocyte migration system was investigated. The migration of human buffy coat cells was inhibited by a soluble product of activated lymphocytes. This factor was found to have an elution pattern in Sephadex G-100 gels similar to that of albumin (69,000 daltons), th...
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| Veröffentlicht in: | The Journal of immunology (1950) 1974-04, Vol.112 (4), p.1461-1466 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 112 |
| creator | Rocklin, Ross E |
| description | The mechanism of inhibition in the leukocyte migration system was investigated. The migration of human buffy coat cells was inhibited by a soluble product of activated lymphocytes. This factor was found to have an elution pattern in Sephadex G-100 gels similar to that of albumin (69,000 daltons), thus differentiating it from human migratory inhibitory factor (MIF) (23,000 daltons). Leukocyte inhibitory factor (LIF), like MIF, was shown to be elaborated by sensitized lymphocytes following stimulation by specific antigen. LIF selectively inhibited the migration of polymorphonuclear (PMN) leukocytes but did not affect the migration of guinea pig macrophages or human monocytes. Thus, the leukocyte migration system has been shown to be mediated by a separate factor (LIF) and different indicator cells (PMN leukocytes) than the MIF-mediated system of migration inhibition which utilizes guinea pig macrophages or human monocytes as indicator cells. |
| doi_str_mv | 10.4049/jimmunol.112.4.1461 |
| format | Article |
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The migration of human buffy coat cells was inhibited by a soluble product of activated lymphocytes. This factor was found to have an elution pattern in Sephadex G-100 gels similar to that of albumin (69,000 daltons), thus differentiating it from human migratory inhibitory factor (MIF) (23,000 daltons). Leukocyte inhibitory factor (LIF), like MIF, was shown to be elaborated by sensitized lymphocytes following stimulation by specific antigen. LIF selectively inhibited the migration of polymorphonuclear (PMN) leukocytes but did not affect the migration of guinea pig macrophages or human monocytes. Thus, the leukocyte migration system has been shown to be mediated by a separate factor (LIF) and different indicator cells (PMN leukocytes) than the MIF-mediated system of migration inhibition which utilizes guinea pig macrophages or human monocytes as indicator cells.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.112.4.1461</identifier><identifier>PMID: 4592603</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Animals ; Candida - immunology ; Cell Migration Inhibition ; Cells, Cultured ; Chromatography, Gel ; Dermatitis, Contact ; Guinea Pigs ; Humans ; Leukocytes - immunology ; Lymphocytes - immunology ; Lymphocytes - metabolism ; Macrophage Migration-Inhibitory Factors ; Macrophages - immunology ; Streptodornase and Streptokinase ; Tuberculin</subject><ispartof>The Journal of immunology (1950), 1974-04, Vol.112 (4), p.1461-1466</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-54b67134aa2dce384843cce93030da95f7d332321fc55772cfafc577ab5c94493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4592603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rocklin, Ross E</creatorcontrib><title>Products of Activated Lymphocytes: Leukocyte Inhibitory Factor (LIF) Distinct from Migration Inhibitory Factor (MIF)</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The mechanism of inhibition in the leukocyte migration system was investigated. The migration of human buffy coat cells was inhibited by a soluble product of activated lymphocytes. This factor was found to have an elution pattern in Sephadex G-100 gels similar to that of albumin (69,000 daltons), thus differentiating it from human migratory inhibitory factor (MIF) (23,000 daltons). Leukocyte inhibitory factor (LIF), like MIF, was shown to be elaborated by sensitized lymphocytes following stimulation by specific antigen. LIF selectively inhibited the migration of polymorphonuclear (PMN) leukocytes but did not affect the migration of guinea pig macrophages or human monocytes. Thus, the leukocyte migration system has been shown to be mediated by a separate factor (LIF) and different indicator cells (PMN leukocytes) than the MIF-mediated system of migration inhibition which utilizes guinea pig macrophages or human monocytes as indicator cells.</description><subject>Animals</subject><subject>Candida - immunology</subject><subject>Cell Migration Inhibition</subject><subject>Cells, Cultured</subject><subject>Chromatography, Gel</subject><subject>Dermatitis, Contact</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Leukocytes - immunology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - metabolism</subject><subject>Macrophage Migration-Inhibitory Factors</subject><subject>Macrophages - immunology</subject><subject>Streptodornase and Streptokinase</subject><subject>Tuberculin</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtPwzAUhS0EKqXwCxCSJx5Dip95sCGgUCkIBpgt13GoIYmL7VD132NoQQxM50rnu2f4ADjEaMwQK85fTdv2nW3GGJMxG2OW4i0wxJyjJE1Rug2GCBGS4CzNdsGe968IoRQRNgADxguSIjoE4dHZqlfBQ1vDSxXMhwy6guWqXcytWgXtL2Cp-7fvG067uZmZYN0KTqSKCU_L6eQMXhsfTKcCrJ1t4b15cTIY2_3H30d-H-zUsvH6YJMj8Dy5ebq6S8qH2-nVZZkoSklIOJulGaZMSlIpTXOWM6qULiiiqJIFr7MqcpTgWnGeZUTVMl5ZJmdcFYwVdASO17sLZ9977YNojVe6aWSnbe9FTijiOc4jSNegctZ7p2uxcKaVbiUwEl-uxY9rEV0LJr5cx6-jzXw_a3X1-7ORG_uTdT83L_OlcVr4VjZNpLFYLpd_lj4BVvWKfw</recordid><startdate>197404</startdate><enddate>197404</enddate><creator>Rocklin, Ross E</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197404</creationdate><title>Products of Activated Lymphocytes: Leukocyte Inhibitory Factor (LIF) Distinct from Migration Inhibitory Factor (MIF)</title><author>Rocklin, Ross E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-54b67134aa2dce384843cce93030da95f7d332321fc55772cfafc577ab5c94493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Candida - immunology</topic><topic>Cell Migration Inhibition</topic><topic>Cells, Cultured</topic><topic>Chromatography, Gel</topic><topic>Dermatitis, Contact</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Leukocytes - immunology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - metabolism</topic><topic>Macrophage Migration-Inhibitory Factors</topic><topic>Macrophages - immunology</topic><topic>Streptodornase and Streptokinase</topic><topic>Tuberculin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rocklin, Ross E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rocklin, Ross E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Products of Activated Lymphocytes: Leukocyte Inhibitory Factor (LIF) Distinct from Migration Inhibitory Factor (MIF)</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1974-04</date><risdate>1974</risdate><volume>112</volume><issue>4</issue><spage>1461</spage><epage>1466</epage><pages>1461-1466</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>The mechanism of inhibition in the leukocyte migration system was investigated. The migration of human buffy coat cells was inhibited by a soluble product of activated lymphocytes. This factor was found to have an elution pattern in Sephadex G-100 gels similar to that of albumin (69,000 daltons), thus differentiating it from human migratory inhibitory factor (MIF) (23,000 daltons). Leukocyte inhibitory factor (LIF), like MIF, was shown to be elaborated by sensitized lymphocytes following stimulation by specific antigen. LIF selectively inhibited the migration of polymorphonuclear (PMN) leukocytes but did not affect the migration of guinea pig macrophages or human monocytes. 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| ispartof | The Journal of immunology (1950), 1974-04, Vol.112 (4), p.1461-1466 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Candida - immunology Cell Migration Inhibition Cells, Cultured Chromatography, Gel Dermatitis, Contact Guinea Pigs Humans Leukocytes - immunology Lymphocytes - immunology Lymphocytes - metabolism Macrophage Migration-Inhibitory Factors Macrophages - immunology Streptodornase and Streptokinase Tuberculin |
| title | Products of Activated Lymphocytes: Leukocyte Inhibitory Factor (LIF) Distinct from Migration Inhibitory Factor (MIF) |
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