Pharmacokinetics of pentazocine in the rhesus monkey
The time course of pentazocine concentration was followed in the plasma and cerebrums of individual monkeys by obtaining serial samples of both tissues after intravenous administration of tritiated drug. Plasma concentrations of pentazocine were also followed in a monkey after portal vein infusion....
Gespeichert in:
| Veröffentlicht in: | Journal of pharmaceutical sciences 1974-01, Vol.63 (1), p.84-88 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 88 |
|---|---|
| container_issue | 1 |
| container_start_page | 84 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 63 |
| creator | Pittman, K.A. Portmann, G.A. |
| description | The time course of pentazocine concentration was followed in the plasma and cerebrums of individual monkeys by obtaining serial samples of both tissues after intravenous administration of tritiated drug. Plasma concentrations of pentazocine were also followed in a monkey after portal vein infusion. A three-compartment open-system model adequately fits the observed plasma data. The use of the constants derived from that model to predict the time course of pentazocine concentration in the brain results in a good fit with the observed cerebral concentrations. As expected, portal vein infusion caused a reduction in the area below the plasma concentration-time curves and in the percentage of pentazocine excreted in the urine. The relative proportions of known metabolites and their conjugates in urine were determined. |
| doi_str_mv | 10.1002/jps.2600630121 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_82297746</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022354915414285</els_id><sourcerecordid>82297746</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4931-dd090bccfbc26b0e95d7913f7a9f755e18c48a8b93e18bfb84ef4d678ec8c5973</originalsourceid><addsrcrecordid>eNqFkM9LwzAYhoMoc06v3oSevHUmadI0Rxn-RHSwqceQpl9ZtrWdSafOv95Ih-JBPH3h-573hTwIHRM8JBjTs_nKD2mKcZpgQskO6hNOcZxiInZRPwA0TjiT--jA-zkOGOa8h3qMYpawtI_YeKZdpU2zsDW01vioKaMV1K3-aExYRbaO2hlEbgZ-7aOqqRewOUR7pV56ONrOAXq8vJiOruO7h6ub0fldbJhMSFwUWOLcmDI3NM0xSF4ISZJSaFkKzoFkhmU6y2USnnmZZwxKVqQiA5MZLkUyQKdd78o1L2vwraqsN7Bc6hqatVcZpVIIlgZw2IHGNd47KNXK2Uq7jSJYfWlSQZP60RQCJ9vmdV5B8Y1vvYS77O5vdgmbf9rU7Xjyqzvusta38P6d1W6hUpEIrp7vrxSZTsaCPGH1FPis4yGofLXglDcWagOFdWBaVTT2r298AmP6lYU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>82297746</pqid></control><display><type>article</type><title>Pharmacokinetics of pentazocine in the rhesus monkey</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Pittman, K.A. ; Portmann, G.A.</creator><creatorcontrib>Pittman, K.A. ; Portmann, G.A.</creatorcontrib><description>The time course of pentazocine concentration was followed in the plasma and cerebrums of individual monkeys by obtaining serial samples of both tissues after intravenous administration of tritiated drug. Plasma concentrations of pentazocine were also followed in a monkey after portal vein infusion. A three-compartment open-system model adequately fits the observed plasma data. The use of the constants derived from that model to predict the time course of pentazocine concentration in the brain results in a good fit with the observed cerebral concentrations. As expected, portal vein infusion caused a reduction in the area below the plasma concentration-time curves and in the percentage of pentazocine excreted in the urine. The relative proportions of known metabolites and their conjugates in urine were determined.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600630121</identifier><identifier>PMID: 4204346</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; Bicarbonates ; Brain Chemistry - drug effects ; Brain concentration ; Brain concentration, pentazocine—correlated with plasma concentration, rhesus monkey ; Carbonates ; Cerebral Cortex - metabolism ; correlation between plasma and brain concentrations ; Haplorhini ; Kinetics ; Macaca - metabolism ; Male ; Models, Biological ; Pentazocine - blood ; Pentazocine - metabolism ; Pentazocine - pharmacology ; pentazocine-correlated with brain concentration ; pentazocine-correlated with plasma concentration ; Pentazocine-pharmacokinetics ; Pentazocine—pharmacokinetics, correlation between plasma and brain concentrations, rhesus monkey ; Pharmacokinetics-pentazocine ; Pharmacokinetics—pentazocine, correlation between plasma and brain concentrations, rhesus monkey ; Plasma concentration ; Plasma concentration, pentazocine—correlated with brain concentration, rhesus monkey ; rhesus monkey ; Time Factors</subject><ispartof>Journal of pharmaceutical sciences, 1974-01, Vol.63 (1), p.84-88</ispartof><rights>1974 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1974 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4931-dd090bccfbc26b0e95d7913f7a9f755e18c48a8b93e18bfb84ef4d678ec8c5973</citedby><cites>FETCH-LOGICAL-c4931-dd090bccfbc26b0e95d7913f7a9f755e18c48a8b93e18bfb84ef4d678ec8c5973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600630121$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600630121$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4204346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pittman, K.A.</creatorcontrib><creatorcontrib>Portmann, G.A.</creatorcontrib><title>Pharmacokinetics of pentazocine in the rhesus monkey</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The time course of pentazocine concentration was followed in the plasma and cerebrums of individual monkeys by obtaining serial samples of both tissues after intravenous administration of tritiated drug. Plasma concentrations of pentazocine were also followed in a monkey after portal vein infusion. A three-compartment open-system model adequately fits the observed plasma data. The use of the constants derived from that model to predict the time course of pentazocine concentration in the brain results in a good fit with the observed cerebral concentrations. As expected, portal vein infusion caused a reduction in the area below the plasma concentration-time curves and in the percentage of pentazocine excreted in the urine. The relative proportions of known metabolites and their conjugates in urine were determined.</description><subject>Animals</subject><subject>Bicarbonates</subject><subject>Brain Chemistry - drug effects</subject><subject>Brain concentration</subject><subject>Brain concentration, pentazocine—correlated with plasma concentration, rhesus monkey</subject><subject>Carbonates</subject><subject>Cerebral Cortex - metabolism</subject><subject>correlation between plasma and brain concentrations</subject><subject>Haplorhini</subject><subject>Kinetics</subject><subject>Macaca - metabolism</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Pentazocine - blood</subject><subject>Pentazocine - metabolism</subject><subject>Pentazocine - pharmacology</subject><subject>pentazocine-correlated with brain concentration</subject><subject>pentazocine-correlated with plasma concentration</subject><subject>Pentazocine-pharmacokinetics</subject><subject>Pentazocine—pharmacokinetics, correlation between plasma and brain concentrations, rhesus monkey</subject><subject>Pharmacokinetics-pentazocine</subject><subject>Pharmacokinetics—pentazocine, correlation between plasma and brain concentrations, rhesus monkey</subject><subject>Plasma concentration</subject><subject>Plasma concentration, pentazocine—correlated with brain concentration, rhesus monkey</subject><subject>rhesus monkey</subject><subject>Time Factors</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAYhoMoc06v3oSevHUmadI0Rxn-RHSwqceQpl9ZtrWdSafOv95Ih-JBPH3h-573hTwIHRM8JBjTs_nKD2mKcZpgQskO6hNOcZxiInZRPwA0TjiT--jA-zkOGOa8h3qMYpawtI_YeKZdpU2zsDW01vioKaMV1K3-aExYRbaO2hlEbgZ-7aOqqRewOUR7pV56ONrOAXq8vJiOruO7h6ub0fldbJhMSFwUWOLcmDI3NM0xSF4ISZJSaFkKzoFkhmU6y2USnnmZZwxKVqQiA5MZLkUyQKdd78o1L2vwraqsN7Bc6hqatVcZpVIIlgZw2IHGNd47KNXK2Uq7jSJYfWlSQZP60RQCJ9vmdV5B8Y1vvYS77O5vdgmbf9rU7Xjyqzvusta38P6d1W6hUpEIrp7vrxSZTsaCPGH1FPis4yGofLXglDcWagOFdWBaVTT2r298AmP6lYU</recordid><startdate>197401</startdate><enddate>197401</enddate><creator>Pittman, K.A.</creator><creator>Portmann, G.A.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197401</creationdate><title>Pharmacokinetics of pentazocine in the rhesus monkey</title><author>Pittman, K.A. ; Portmann, G.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4931-dd090bccfbc26b0e95d7913f7a9f755e18c48a8b93e18bfb84ef4d678ec8c5973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Bicarbonates</topic><topic>Brain Chemistry - drug effects</topic><topic>Brain concentration</topic><topic>Brain concentration, pentazocine—correlated with plasma concentration, rhesus monkey</topic><topic>Carbonates</topic><topic>Cerebral Cortex - metabolism</topic><topic>correlation between plasma and brain concentrations</topic><topic>Haplorhini</topic><topic>Kinetics</topic><topic>Macaca - metabolism</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Pentazocine - blood</topic><topic>Pentazocine - metabolism</topic><topic>Pentazocine - pharmacology</topic><topic>pentazocine-correlated with brain concentration</topic><topic>pentazocine-correlated with plasma concentration</topic><topic>Pentazocine-pharmacokinetics</topic><topic>Pentazocine—pharmacokinetics, correlation between plasma and brain concentrations, rhesus monkey</topic><topic>Pharmacokinetics-pentazocine</topic><topic>Pharmacokinetics—pentazocine, correlation between plasma and brain concentrations, rhesus monkey</topic><topic>Plasma concentration</topic><topic>Plasma concentration, pentazocine—correlated with brain concentration, rhesus monkey</topic><topic>rhesus monkey</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pittman, K.A.</creatorcontrib><creatorcontrib>Portmann, G.A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pittman, K.A.</au><au>Portmann, G.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of pentazocine in the rhesus monkey</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1974-01</date><risdate>1974</risdate><volume>63</volume><issue>1</issue><spage>84</spage><epage>88</epage><pages>84-88</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The time course of pentazocine concentration was followed in the plasma and cerebrums of individual monkeys by obtaining serial samples of both tissues after intravenous administration of tritiated drug. Plasma concentrations of pentazocine were also followed in a monkey after portal vein infusion. A three-compartment open-system model adequately fits the observed plasma data. The use of the constants derived from that model to predict the time course of pentazocine concentration in the brain results in a good fit with the observed cerebral concentrations. As expected, portal vein infusion caused a reduction in the area below the plasma concentration-time curves and in the percentage of pentazocine excreted in the urine. The relative proportions of known metabolites and their conjugates in urine were determined.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>4204346</pmid><doi>10.1002/jps.2600630121</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1974-01, Vol.63 (1), p.84-88 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82297746 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Animals Bicarbonates Brain Chemistry - drug effects Brain concentration Brain concentration, pentazocine—correlated with plasma concentration, rhesus monkey Carbonates Cerebral Cortex - metabolism correlation between plasma and brain concentrations Haplorhini Kinetics Macaca - metabolism Male Models, Biological Pentazocine - blood Pentazocine - metabolism Pentazocine - pharmacology pentazocine-correlated with brain concentration pentazocine-correlated with plasma concentration Pentazocine-pharmacokinetics Pentazocine—pharmacokinetics, correlation between plasma and brain concentrations, rhesus monkey Pharmacokinetics-pentazocine Pharmacokinetics—pentazocine, correlation between plasma and brain concentrations, rhesus monkey Plasma concentration Plasma concentration, pentazocine—correlated with brain concentration, rhesus monkey rhesus monkey Time Factors |
| title | Pharmacokinetics of pentazocine in the rhesus monkey |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T01%3A50%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pharmacokinetics%20of%20pentazocine%20in%20the%20rhesus%20monkey&rft.jtitle=Journal%20of%20pharmaceutical%20sciences&rft.au=Pittman,%20K.A.&rft.date=1974-01&rft.volume=63&rft.issue=1&rft.spage=84&rft.epage=88&rft.pages=84-88&rft.issn=0022-3549&rft.eissn=1520-6017&rft_id=info:doi/10.1002/jps.2600630121&rft_dat=%3Cproquest_cross%3E82297746%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=82297746&rft_id=info:pmid/4204346&rft_els_id=S0022354915414285&rfr_iscdi=true |