Binding of an Antiviral Agent (Kethoxal) by Various Metabolites
Summary Kethoxal (β-ethoxy-α-ketobutyraldehyde hydrate) reacted chemically with a variety of normal metabolites. Some of these reactions (e.g., those with cysteine and arginine) resulted in rapid loss of antiviral activity; others (e.g., with glycine and intact gelatin) in a more gradual loss of act...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1959-02, Vol.100 (2), p.312-315 |
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| container_issue | 2 |
| container_start_page | 312 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 100 |
| creator | Underwood, Gerald E. Siem, Robert A. Gerpheide, Shirley A. Hunter, James H. |
| description | Summary
Kethoxal (β-ethoxy-α-ketobutyraldehyde hydrate) reacted chemically with a variety of normal metabolites. Some of these reactions (e.g., those with cysteine and arginine) resulted in rapid loss of antiviral activity; others (e.g., with glycine and intact gelatin) in a more gradual loss of activity, while still others, particularly with serine and threonine, gave products possessing apparently undiminished activity. It was concluded that lack of significant antiviral activity by Kethoxal in animals could be attributed principally to its rapid binding and inactivation by proteins, amino acids and other metabolites. |
| doi_str_mv | 10.3181/00379727-100-24611 |
| format | Article |
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Kethoxal (β-ethoxy-α-ketobutyraldehyde hydrate) reacted chemically with a variety of normal metabolites. Some of these reactions (e.g., those with cysteine and arginine) resulted in rapid loss of antiviral activity; others (e.g., with glycine and intact gelatin) in a more gradual loss of activity, while still others, particularly with serine and threonine, gave products possessing apparently undiminished activity. It was concluded that lack of significant antiviral activity by Kethoxal in animals could be attributed principally to its rapid binding and inactivation by proteins, amino acids and other metabolites.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-100-24611</identifier><identifier>PMID: 13634123</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aldehydes ; Antiviral Agents ; Ketones ; Old Medline ; Viruses - drug effects</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1959-02, Vol.100 (2), p.312-315</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-712de6dff26a40d589e60b54bd27417aad3eb227ea9e2bc1aa2d3bb74ed0188f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13634123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Underwood, Gerald E.</creatorcontrib><creatorcontrib>Siem, Robert A.</creatorcontrib><creatorcontrib>Gerpheide, Shirley A.</creatorcontrib><creatorcontrib>Hunter, James H.</creatorcontrib><title>Binding of an Antiviral Agent (Kethoxal) by Various Metabolites</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Kethoxal (β-ethoxy-α-ketobutyraldehyde hydrate) reacted chemically with a variety of normal metabolites. Some of these reactions (e.g., those with cysteine and arginine) resulted in rapid loss of antiviral activity; others (e.g., with glycine and intact gelatin) in a more gradual loss of activity, while still others, particularly with serine and threonine, gave products possessing apparently undiminished activity. It was concluded that lack of significant antiviral activity by Kethoxal in animals could be attributed principally to its rapid binding and inactivation by proteins, amino acids and other metabolites.</description><subject>Aldehydes</subject><subject>Antiviral Agents</subject><subject>Ketones</subject><subject>Old Medline</subject><subject>Viruses - drug effects</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1959</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EouXxAyyQVwgWoX4kdrJCpeIlitgAW8uOJ8VVmhTbQfTvSWkRO1Yjjc7cmTkInVByyWlOR4RwWUgmE0pIwlJB6Q4a0oxnCRdFsYuGayBZEwN0EMKcEJpJJvbRgHLBU8r4EF1du8a6ZobbCusGj5voPp3XNR7PoIn4_BHie_ul6wtsVvhNe9d2AT9B1KatXYRwhPYqXQc43tZD9Hp78zK5T6bPdw-T8TQp-0UxkZRZELaqmNApsVlegCAmS41lMqVSa8vBMCZBF8BMSbVmlhsjU7CE5nnFD9HZJnfp248OQlQLF0qoa91Af5LKGStElskeZBuw9G0IHiq19G6h_UpRotba1K-2vkHUj7Z-6HSb3pkF2L-RraceGG2AoGeg5m3nm_7b_yK_AWk-dNE</recordid><startdate>195902</startdate><enddate>195902</enddate><creator>Underwood, Gerald E.</creator><creator>Siem, Robert A.</creator><creator>Gerpheide, Shirley A.</creator><creator>Hunter, James H.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195902</creationdate><title>Binding of an Antiviral Agent (Kethoxal) by Various Metabolites</title><author>Underwood, Gerald E. ; Siem, Robert A. ; Gerpheide, Shirley A. ; Hunter, James H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-712de6dff26a40d589e60b54bd27417aad3eb227ea9e2bc1aa2d3bb74ed0188f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1959</creationdate><topic>Aldehydes</topic><topic>Antiviral Agents</topic><topic>Ketones</topic><topic>Old Medline</topic><topic>Viruses - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Underwood, Gerald E.</creatorcontrib><creatorcontrib>Siem, Robert A.</creatorcontrib><creatorcontrib>Gerpheide, Shirley A.</creatorcontrib><creatorcontrib>Hunter, James H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Underwood, Gerald E.</au><au>Siem, Robert A.</au><au>Gerpheide, Shirley A.</au><au>Hunter, James H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binding of an Antiviral Agent (Kethoxal) by Various Metabolites</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1959-02</date><risdate>1959</risdate><volume>100</volume><issue>2</issue><spage>312</spage><epage>315</epage><pages>312-315</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Kethoxal (β-ethoxy-α-ketobutyraldehyde hydrate) reacted chemically with a variety of normal metabolites. Some of these reactions (e.g., those with cysteine and arginine) resulted in rapid loss of antiviral activity; others (e.g., with glycine and intact gelatin) in a more gradual loss of activity, while still others, particularly with serine and threonine, gave products possessing apparently undiminished activity. It was concluded that lack of significant antiviral activity by Kethoxal in animals could be attributed principally to its rapid binding and inactivation by proteins, amino acids and other metabolites.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13634123</pmid><doi>10.3181/00379727-100-24611</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1959-02, Vol.100 (2), p.312-315 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82296557 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aldehydes Antiviral Agents Ketones Old Medline Viruses - drug effects |
| title | Binding of an Antiviral Agent (Kethoxal) by Various Metabolites |
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