Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation

The aim of this study is to examine the ability of the bile acid analogues obtained by chemical modification of ursodeoxycholic acid (UDCA) for TGR5 activation. Eleven UDCA analogues including 3- or 7-methylated UDCAs and amino acid conjugates were investigated as to their ability to activate TGR5 b...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2011/01/01, Vol.34(1), pp.1-7
Hauptverfasser:	Iguchi, Yusuke, Nishimaki-Mogami, Tomoko, Yamaguchi, Masafumi, Teraoka, Fumiteru, Kaneko, Tetsuo, Une, Mizuho
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug farnesoid X receptor Gene Expression Regulation - drug effects HEK293 Cells Humans metabolic syndrome Molecular Structure Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Structure-Activity Relationship TGR5 ursodeoxycholic acid Ursodeoxycholic Acid - analogs & derivatives Ursodeoxycholic Acid - chemistry Ursodeoxycholic Acid - pharmacology
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