TNF receptor‐associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets

Background: Reactive oxygen species generation is one consequence of ligand engagement of platelet glycoprotein (GP) receptors GPIb‐IX‐V and GPVI, which bind VWF/collagen and initiate thrombosis at arterial shear; however, the precise molecular mechanism coupling redox pathway activation to engageme...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2011-01, Vol.9 (1), p.163-172
Hauptverfasser:	ARTHUR, J. F., SHEN, Y., GARDINER, E. E., COLEMAN, L., KENNY, D., ANDREWS, R. K., BERNDT, M. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - metabolism Chromatography, Affinity Focal Adhesion Kinase 2 - blood glycoprotein Ib‐IX‐V glycoprotein VI Humans Immunoprecipitation Intracellular Signaling Peptides and Proteins - blood LIM Domain Proteins NADPH oxidase NADPH Oxidases - blood Oxidation-Reduction Phosphorylation Platelet Glycoprotein GPIb-IX Complex - metabolism Platelet Membrane Glycoproteins - metabolism platelets Protein Array Analysis Protein Binding Protein Interaction Domains and Motifs Protein Interaction Mapping Recombinant Fusion Proteins - metabolism redox Signal Transduction TNF Receptor-Associated Factor 4 - blood TRAF4
Online-Zugang:	Volltext
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