A Proteomic Approach in Investigating the Hepatoprotective Mechanism of Schisandrin B: Role of Raf Kinase Inhibitor Protein

To identify key proteins involved in the hepatoprotection afforded by schisandrin B (Sch B), we used a proteomic approach to screen proteins that were specifically regulated by Sch B in mouse livers and to investigate the role of the proteins in hepatoprotection. Thirteen proteins were specifically...

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Veröffentlicht in:	Journal of proteome research 2011-01, Vol.10 (1), p.299-304
Hauptverfasser:	Chen, Yan, Ip, Siu-Po, Ko, Kam-Ming, Poon, Terence C. W, Ng, Eddy W. Y, Lai, Paul B. S, Mao, Qing-Qiu, Xian, Yan-Fang, Che, Chun-Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Blotting, Western Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - prevention & control Cyclooctanes - pharmacology Electrophoresis, Gel, Two-Dimensional Extracellular Signal-Regulated MAP Kinases - metabolism Lignans - pharmacology Male MAP Kinase Kinase Kinases - metabolism Mice Mice, Inbred BALB C Phosphatidylethanolamine Binding Protein - chemistry Phosphatidylethanolamine Binding Protein - metabolism Polycyclic Compounds - pharmacology Protective Agents - pharmacology Proteins - chemistry Proteins - classification Proteins - metabolism Proteome - chemistry Proteome - drug effects Proteome - metabolism Proteomics - methods Proto-Oncogene Proteins c-raf - metabolism Signal Transduction - drug effects Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Statistics, Nonparametric
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