The role of diffusion 3-Tesla MRI in detecting prostate cancer before needle biopsy: multiparametric study of 111 patients
Evaluate diffusion MRI in the multiparametric assessment of prostate cancer before needle biopsy. One hundred eleven patients with suspected prostate cancer (mean age: 63 years old, median PSA: 7 ng/mL) were examined before undergoing needle biopsy (59 patients with a history of a negative biopsy an...
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| Veröffentlicht in: | Journal de radiologie 2010-11, Vol.91 (11 Pt 1), p.1121-1128 |
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| creator | Roy, C Pasquali, R Matau, A Bazille, G Lang, H |
| description | Evaluate diffusion MRI in the multiparametric assessment of prostate cancer before needle biopsy.
One hundred eleven patients with suspected prostate cancer (mean age: 63 years old, median PSA: 7 ng/mL) were examined before undergoing needle biopsy (59 patients with a history of a negative biopsy and 52 without a history of biopsy). A diffusion sequence type SS SE-EPI (TR/TE: 5357/58, fEPI: 73, b 0 and 1000 s/mm², axial) with a qualitative analysis of the ADC map was performed in addition to T2 and T1 gadolinium enhanced sequences on 3 T MRI with an endorectal coil. The histological correlations were obtained by ultrasound guided needle biopsy (85 patients) or radical prostatectomy (26 patients).
The correlation of the results of the diffusion sequence in the series of the 111 patients and the biopsies of the entire prostate or the hemiprostate had a sensitivity of: 92%, 77%; a specificity of: 55%, 70%; a positive predictive value of: 77%, 62%; a negative predictive value of: 84%, 80% and an efficacy of 78%, 75% respectively. The agreement of the three sequences had a specificity of 84.3%.
The sensitivity of diffusion MRI is high for the detection of cancer of the prostate. Specificity of sequences is good. The results of simple visual assessment of the ADC map are good. |
| doi_str_mv | 10.1016/S0221-0363(10)70157-8 |
| format | Article |
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One hundred eleven patients with suspected prostate cancer (mean age: 63 years old, median PSA: 7 ng/mL) were examined before undergoing needle biopsy (59 patients with a history of a negative biopsy and 52 without a history of biopsy). A diffusion sequence type SS SE-EPI (TR/TE: 5357/58, fEPI: 73, b 0 and 1000 s/mm², axial) with a qualitative analysis of the ADC map was performed in addition to T2 and T1 gadolinium enhanced sequences on 3 T MRI with an endorectal coil. The histological correlations were obtained by ultrasound guided needle biopsy (85 patients) or radical prostatectomy (26 patients).
The correlation of the results of the diffusion sequence in the series of the 111 patients and the biopsies of the entire prostate or the hemiprostate had a sensitivity of: 92%, 77%; a specificity of: 55%, 70%; a positive predictive value of: 77%, 62%; a negative predictive value of: 84%, 80% and an efficacy of 78%, 75% respectively. The agreement of the three sequences had a specificity of 84.3%.
The sensitivity of diffusion MRI is high for the detection of cancer of the prostate. Specificity of sequences is good. The results of simple visual assessment of the ADC map are good.</description><identifier>ISSN: 0221-0363</identifier><identifier>DOI: 10.1016/S0221-0363(10)70157-8</identifier><identifier>PMID: 21178875</identifier><language>fre</language><publisher>France</publisher><subject>Aged ; Biomarkers, Tumor - blood ; Biopsy, Needle ; Cohort Studies ; Contrast Media - administration & dosage ; Diffusion Magnetic Resonance Imaging ; Endosonography ; Gadolinium ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prostate - pathology ; Prostate-Specific Antigen - blood ; Prostatectomy ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - pathology ; Sensitivity and Specificity ; Ultrasonography, Interventional</subject><ispartof>Journal de radiologie, 2010-11, Vol.91 (11 Pt 1), p.1121-1128</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21178875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roy, C</creatorcontrib><creatorcontrib>Pasquali, R</creatorcontrib><creatorcontrib>Matau, A</creatorcontrib><creatorcontrib>Bazille, G</creatorcontrib><creatorcontrib>Lang, H</creatorcontrib><title>The role of diffusion 3-Tesla MRI in detecting prostate cancer before needle biopsy: multiparametric study of 111 patients</title><title>Journal de radiologie</title><addtitle>J Radiol</addtitle><description>Evaluate diffusion MRI in the multiparametric assessment of prostate cancer before needle biopsy.
One hundred eleven patients with suspected prostate cancer (mean age: 63 years old, median PSA: 7 ng/mL) were examined before undergoing needle biopsy (59 patients with a history of a negative biopsy and 52 without a history of biopsy). A diffusion sequence type SS SE-EPI (TR/TE: 5357/58, fEPI: 73, b 0 and 1000 s/mm², axial) with a qualitative analysis of the ADC map was performed in addition to T2 and T1 gadolinium enhanced sequences on 3 T MRI with an endorectal coil. The histological correlations were obtained by ultrasound guided needle biopsy (85 patients) or radical prostatectomy (26 patients).
The correlation of the results of the diffusion sequence in the series of the 111 patients and the biopsies of the entire prostate or the hemiprostate had a sensitivity of: 92%, 77%; a specificity of: 55%, 70%; a positive predictive value of: 77%, 62%; a negative predictive value of: 84%, 80% and an efficacy of 78%, 75% respectively. The agreement of the three sequences had a specificity of 84.3%.
The sensitivity of diffusion MRI is high for the detection of cancer of the prostate. Specificity of sequences is good. The results of simple visual assessment of the ADC map are good.</description><subject>Aged</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biopsy, Needle</subject><subject>Cohort Studies</subject><subject>Contrast Media - administration & dosage</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Endosonography</subject><subject>Gadolinium</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Prostate - pathology</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography, Interventional</subject><issn>0221-0363</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMlOwzAU9AFES-ETQL4Bh4CfncQxN1SxVCpCgnKOHOcZjLJhO4fy9QRROI00Gs1GyAmwS2CQX70wziFhIhfnwC4kg0wmxR6Z_9MzchjCB2McIE0PyGxCWRQym5OvzTtS3zdIe0trZ-0YXN9RkWwwNJo-Pq-o62iNEU103RsdfB-ijkiN7gx6WqHtPdIOsZ48KtcPYXtN27GJbtBetxi9MzTEsd7-JAAAHXR02MVwRPatbgIe73BBXu9uN8uHZP10v1rerJMBUhYTxTLFeZXnIpNaK5Oi4sBBMYnKGABdZLbOlc6kzfU0WOWSCQ1M1mgVZCAW5OzXd-r-OWKIZeuCwabRHfZjKAvOFeNiumlBTnfKsWqxLgfvWu235d9d4hu_02rT</recordid><startdate>201011</startdate><enddate>201011</enddate><creator>Roy, C</creator><creator>Pasquali, R</creator><creator>Matau, A</creator><creator>Bazille, G</creator><creator>Lang, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201011</creationdate><title>The role of diffusion 3-Tesla MRI in detecting prostate cancer before needle biopsy: multiparametric study of 111 patients</title><author>Roy, C ; Pasquali, R ; Matau, A ; Bazille, G ; Lang, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-905922b66357aa9c4e92121907e9cc11a85fd69a57f6a22196703a107def91513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biopsy, Needle</topic><topic>Cohort Studies</topic><topic>Contrast Media - administration & dosage</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Endosonography</topic><topic>Gadolinium</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Prostate - pathology</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography, Interventional</topic><toplevel>online_resources</toplevel><creatorcontrib>Roy, C</creatorcontrib><creatorcontrib>Pasquali, R</creatorcontrib><creatorcontrib>Matau, A</creatorcontrib><creatorcontrib>Bazille, G</creatorcontrib><creatorcontrib>Lang, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal de radiologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roy, C</au><au>Pasquali, R</au><au>Matau, A</au><au>Bazille, G</au><au>Lang, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of diffusion 3-Tesla MRI in detecting prostate cancer before needle biopsy: multiparametric study of 111 patients</atitle><jtitle>Journal de radiologie</jtitle><addtitle>J Radiol</addtitle><date>2010-11</date><risdate>2010</risdate><volume>91</volume><issue>11 Pt 1</issue><spage>1121</spage><epage>1128</epage><pages>1121-1128</pages><issn>0221-0363</issn><abstract>Evaluate diffusion MRI in the multiparametric assessment of prostate cancer before needle biopsy.
One hundred eleven patients with suspected prostate cancer (mean age: 63 years old, median PSA: 7 ng/mL) were examined before undergoing needle biopsy (59 patients with a history of a negative biopsy and 52 without a history of biopsy). A diffusion sequence type SS SE-EPI (TR/TE: 5357/58, fEPI: 73, b 0 and 1000 s/mm², axial) with a qualitative analysis of the ADC map was performed in addition to T2 and T1 gadolinium enhanced sequences on 3 T MRI with an endorectal coil. The histological correlations were obtained by ultrasound guided needle biopsy (85 patients) or radical prostatectomy (26 patients).
The correlation of the results of the diffusion sequence in the series of the 111 patients and the biopsies of the entire prostate or the hemiprostate had a sensitivity of: 92%, 77%; a specificity of: 55%, 70%; a positive predictive value of: 77%, 62%; a negative predictive value of: 84%, 80% and an efficacy of 78%, 75% respectively. The agreement of the three sequences had a specificity of 84.3%.
The sensitivity of diffusion MRI is high for the detection of cancer of the prostate. Specificity of sequences is good. The results of simple visual assessment of the ADC map are good.</abstract><cop>France</cop><pmid>21178875</pmid><doi>10.1016/S0221-0363(10)70157-8</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Biomarkers, Tumor - blood Biopsy, Needle Cohort Studies Contrast Media - administration & dosage Diffusion Magnetic Resonance Imaging Endosonography Gadolinium Humans Image Processing, Computer-Assisted Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prostate - pathology Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Sensitivity and Specificity Ultrasonography, Interventional |
| title | The role of diffusion 3-Tesla MRI in detecting prostate cancer before needle biopsy: multiparametric study of 111 patients |
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