Comparison of patient survival in non-diabetic transplant-listed patients initially treated with haemodialysis or peritoneal dialysis
It is still not known whether patients survive longer on one modality of dialysis compared to the other. We have tried to answer this question using data from the Scottish Renal Registry. To avoid the confounding effects of co-morbidity, we limited our survival analysis to those patients listed for...
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Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2011, Vol.26 (1), p.245-252 |
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creator | TRAYNOR, Jamie P THOMSON, Peter C SIMPSON, Keith TOYESE AYANSINA, Dolapo PRESCOTT, Gordon James MACTIER, Robert A |
description | It is still not known whether patients survive longer on one modality of dialysis compared to the other. We have tried to answer this question using data from the Scottish Renal Registry.
To avoid the confounding effects of co-morbidity, we limited our survival analysis to those patients listed for a renal transplant and excluded patients with a primary renal diagnosis (PRD) of diabetic nephropathy. We studied patients starting dialysis between 01 January 1982 and 31 December 2006.
Three thousand one hundred and ninety-seven patients fulfilled our criteria. A Kaplan-Meier plot showed no difference in survival between initial dialysis modality (log-rank P = 0.996). In the Cox regression model, initial dialysis modality was not a significant predictor of survival; hazard ratio = 0.97 (95% CI 0.80 to 1.18) after adjusting for age, sex and PRD. Age at the start of dialysis, hazard ratio = 1.05 (95% CI 1.04 to 1.06) and a PRD group of 'multi-system disease' or 'unknown' were found to significantly influence survival. When survival was also censored for change in modality, there was no difference in survival over the whole study period with the hazard of death for patients on haemodialysis compared to those on peritoneal dialysis being 1.04 (95% CI 0.78 to 1.38; P = 0.803). Age at the start of dialysis remained a significant predictor of death.
This study shows that there was no survival advantage between initial dialysis modalities in non-diabetic patients who are deemed healthy enough for listing for a renal transplant. |
doi_str_mv | 10.1093/ndt/gfq361 |
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To avoid the confounding effects of co-morbidity, we limited our survival analysis to those patients listed for a renal transplant and excluded patients with a primary renal diagnosis (PRD) of diabetic nephropathy. We studied patients starting dialysis between 01 January 1982 and 31 December 2006.
Three thousand one hundred and ninety-seven patients fulfilled our criteria. A Kaplan-Meier plot showed no difference in survival between initial dialysis modality (log-rank P = 0.996). In the Cox regression model, initial dialysis modality was not a significant predictor of survival; hazard ratio = 0.97 (95% CI 0.80 to 1.18) after adjusting for age, sex and PRD. Age at the start of dialysis, hazard ratio = 1.05 (95% CI 1.04 to 1.06) and a PRD group of 'multi-system disease' or 'unknown' were found to significantly influence survival. When survival was also censored for change in modality, there was no difference in survival over the whole study period with the hazard of death for patients on haemodialysis compared to those on peritoneal dialysis being 1.04 (95% CI 0.78 to 1.38; P = 0.803). Age at the start of dialysis remained a significant predictor of death.
This study shows that there was no survival advantage between initial dialysis modalities in non-diabetic patients who are deemed healthy enough for listing for a renal transplant.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfq361</identifier><identifier>PMID: 20659905</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Diabetes Mellitus ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - therapy ; Kidney Transplantation ; Male ; Medical sciences ; Middle Aged ; Peritoneal Dialysis - mortality ; Registries ; Renal Dialysis - mortality ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Survival Rate ; Treatment Outcome</subject><ispartof>Nephrology, dialysis, transplantation, 2011, Vol.26 (1), p.245-252</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-8a2b72ec527c703592dc4684730d70dc8bef0db91c3fa62409ffc83d9df979193</citedby><cites>FETCH-LOGICAL-c352t-8a2b72ec527c703592dc4684730d70dc8bef0db91c3fa62409ffc83d9df979193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23860612$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20659905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TRAYNOR, Jamie P</creatorcontrib><creatorcontrib>THOMSON, Peter C</creatorcontrib><creatorcontrib>SIMPSON, Keith</creatorcontrib><creatorcontrib>TOYESE AYANSINA, Dolapo</creatorcontrib><creatorcontrib>PRESCOTT, Gordon James</creatorcontrib><creatorcontrib>MACTIER, Robert A</creatorcontrib><creatorcontrib>Scottish Renal Registry</creatorcontrib><creatorcontrib>On behalf of the Scottish Renal Registry, Walton Building, Glasgow Royal Infirmary, Glasgow G4 0SF, UK</creatorcontrib><title>Comparison of patient survival in non-diabetic transplant-listed patients initially treated with haemodialysis or peritoneal dialysis</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>It is still not known whether patients survive longer on one modality of dialysis compared to the other. We have tried to answer this question using data from the Scottish Renal Registry.
To avoid the confounding effects of co-morbidity, we limited our survival analysis to those patients listed for a renal transplant and excluded patients with a primary renal diagnosis (PRD) of diabetic nephropathy. We studied patients starting dialysis between 01 January 1982 and 31 December 2006.
Three thousand one hundred and ninety-seven patients fulfilled our criteria. A Kaplan-Meier plot showed no difference in survival between initial dialysis modality (log-rank P = 0.996). In the Cox regression model, initial dialysis modality was not a significant predictor of survival; hazard ratio = 0.97 (95% CI 0.80 to 1.18) after adjusting for age, sex and PRD. Age at the start of dialysis, hazard ratio = 1.05 (95% CI 1.04 to 1.06) and a PRD group of 'multi-system disease' or 'unknown' were found to significantly influence survival. When survival was also censored for change in modality, there was no difference in survival over the whole study period with the hazard of death for patients on haemodialysis compared to those on peritoneal dialysis being 1.04 (95% CI 0.78 to 1.38; P = 0.803). Age at the start of dialysis remained a significant predictor of death.
This study shows that there was no survival advantage between initial dialysis modalities in non-diabetic patients who are deemed healthy enough for listing for a renal transplant.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peritoneal Dialysis - mortality</subject><subject>Registries</subject><subject>Renal Dialysis - mortality</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE2LFDEQhoMo7uzqxR8guYiw0G4lme50jjL4BQte9Nyk8-FG0klvKrPL_AD_t1lmRk8FVc_7Qj2EvGHwgYESN8nWm1_-XgzsGdmw7QAdF2P_nGzakXXQg7ogl4i_AUBxKV-SCw5DrxT0G_Jnl5dVl4A50ezpqmtwqVLcl4fwoCMNiaacOhv07GowtBadcI061S4GrM6eI9jQUIOO8dAgp59Oj6He0Tvtltzy8YABaS50dSXUnFxrP69fkRdeR3SvT_OK_Pz86cfua3f7_cu33cfbzoie127UfJbcmZ5LI0H0iluzHcatFGAlWDPOzoOdFTPC64FvQXlvRmGV9UoqpsQVeX_sXUu-3zus0xLQuNj-cXmP08i5AtYPspHXR9KUjFicn9YSFl0OE4PpyfrUrE9H6w1-e6rdz4uz_9Cz5ga8OwEajY6-STQB_3NiHGBgXPwFYDOPZQ</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>TRAYNOR, Jamie P</creator><creator>THOMSON, Peter C</creator><creator>SIMPSON, Keith</creator><creator>TOYESE AYANSINA, Dolapo</creator><creator>PRESCOTT, Gordon James</creator><creator>MACTIER, Robert A</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Comparison of patient survival in non-diabetic transplant-listed patients initially treated with haemodialysis or peritoneal dialysis</title><author>TRAYNOR, Jamie P ; THOMSON, Peter C ; SIMPSON, Keith ; TOYESE AYANSINA, Dolapo ; PRESCOTT, Gordon James ; MACTIER, Robert A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-8a2b72ec527c703592dc4684730d70dc8bef0db91c3fa62409ffc83d9df979193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peritoneal Dialysis - mortality</topic><topic>Registries</topic><topic>Renal Dialysis - mortality</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TRAYNOR, Jamie P</creatorcontrib><creatorcontrib>THOMSON, Peter C</creatorcontrib><creatorcontrib>SIMPSON, Keith</creatorcontrib><creatorcontrib>TOYESE AYANSINA, Dolapo</creatorcontrib><creatorcontrib>PRESCOTT, Gordon James</creatorcontrib><creatorcontrib>MACTIER, Robert A</creatorcontrib><creatorcontrib>Scottish Renal Registry</creatorcontrib><creatorcontrib>On behalf of the Scottish Renal Registry, Walton Building, Glasgow Royal Infirmary, Glasgow G4 0SF, UK</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TRAYNOR, Jamie P</au><au>THOMSON, Peter C</au><au>SIMPSON, Keith</au><au>TOYESE AYANSINA, Dolapo</au><au>PRESCOTT, Gordon James</au><au>MACTIER, Robert A</au><aucorp>Scottish Renal Registry</aucorp><aucorp>On behalf of the Scottish Renal Registry, Walton Building, Glasgow Royal Infirmary, Glasgow G4 0SF, UK</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of patient survival in non-diabetic transplant-listed patients initially treated with haemodialysis or peritoneal dialysis</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2011</date><risdate>2011</risdate><volume>26</volume><issue>1</issue><spage>245</spage><epage>252</epage><pages>245-252</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>It is still not known whether patients survive longer on one modality of dialysis compared to the other. We have tried to answer this question using data from the Scottish Renal Registry.
To avoid the confounding effects of co-morbidity, we limited our survival analysis to those patients listed for a renal transplant and excluded patients with a primary renal diagnosis (PRD) of diabetic nephropathy. We studied patients starting dialysis between 01 January 1982 and 31 December 2006.
Three thousand one hundred and ninety-seven patients fulfilled our criteria. A Kaplan-Meier plot showed no difference in survival between initial dialysis modality (log-rank P = 0.996). In the Cox regression model, initial dialysis modality was not a significant predictor of survival; hazard ratio = 0.97 (95% CI 0.80 to 1.18) after adjusting for age, sex and PRD. Age at the start of dialysis, hazard ratio = 1.05 (95% CI 1.04 to 1.06) and a PRD group of 'multi-system disease' or 'unknown' were found to significantly influence survival. When survival was also censored for change in modality, there was no difference in survival over the whole study period with the hazard of death for patients on haemodialysis compared to those on peritoneal dialysis being 1.04 (95% CI 0.78 to 1.38; P = 0.803). Age at the start of dialysis remained a significant predictor of death.
This study shows that there was no survival advantage between initial dialysis modalities in non-diabetic patients who are deemed healthy enough for listing for a renal transplant.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>20659905</pmid><doi>10.1093/ndt/gfq361</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Diabetes Mellitus Emergency and intensive care: renal failure. Dialysis management Female Humans Intensive care medicine Kidney Failure, Chronic - therapy Kidney Transplantation Male Medical sciences Middle Aged Peritoneal Dialysis - mortality Registries Renal Dialysis - mortality Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Survival Rate Treatment Outcome |
title | Comparison of patient survival in non-diabetic transplant-listed patients initially treated with haemodialysis or peritoneal dialysis |
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