Biocompatibility and bioactivity enhancement of Ce stabilized ZrO(2) doped HA coatings by controlled porosity change of Al(2) O(3) substrates
Al(2) O(3) substrates with controlled porosity were manufactured from nanosized powders obtained by plasma processing. It was observed that when increasing the sintering temperature the overall porosity was decreasing, but the pores got larger. In a second step, Ce stabilized ZrO(2) doped hydroxyapa...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2011-02, Vol.96 (2), p.218-224 |
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| creator | Sima, Felix Ristoscu, Carmen Caiteanu, Diana Mihailescu, Cristian N Stefan, Nicolaie Mihailescu, Ion N Prodan, Gabriel Ciupina, Victor Palcevskis, Eriks Krastins, Janis Sima, Livia E Petrescu, Stefana M |
| description | Al(2) O(3) substrates with controlled porosity were manufactured from nanosized powders obtained by plasma processing. It was observed that when increasing the sintering temperature the overall porosity was decreasing, but the pores got larger. In a second step, Ce stabilized ZrO(2) doped hydroxyapatite coatings were pulsed laser deposited onto the Al(2) O(3) substrates. It was shown that the surface morphology, consisting of aggregates and particulates in micrometric range, was altered by the substrate porosity and interface properties, respectively. TEM studies evidenced that Ce stabilized ZrO(2) doped HA particulates ranged from 10 to 50 nm, strongly depending on the Al(2) O(3) porosity. The coatings consisted of HA nanocrystals embedded in an amorphous matrix quite similar to the bone structure. These findings were congruent with the increased biocompatibility and bioactivity of these layers confirmed by enhanced growing and proliferation of human mesenchymal stem cells. |
| doi_str_mv | 10.1002/jbm.b.31755 |
| format | Article |
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It was observed that when increasing the sintering temperature the overall porosity was decreasing, but the pores got larger. In a second step, Ce stabilized ZrO(2) doped hydroxyapatite coatings were pulsed laser deposited onto the Al(2) O(3) substrates. It was shown that the surface morphology, consisting of aggregates and particulates in micrometric range, was altered by the substrate porosity and interface properties, respectively. TEM studies evidenced that Ce stabilized ZrO(2) doped HA particulates ranged from 10 to 50 nm, strongly depending on the Al(2) O(3) porosity. The coatings consisted of HA nanocrystals embedded in an amorphous matrix quite similar to the bone structure. These findings were congruent with the increased biocompatibility and bioactivity of these layers confirmed by enhanced growing and proliferation of human mesenchymal stem cells.</description><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.31755</identifier><identifier>PMID: 21210500</identifier><language>eng</language><publisher>United States</publisher><subject>Aluminum Oxide ; Cell Proliferation ; Cerium ; Coated Materials, Biocompatible - chemistry ; Durapatite ; Humans ; Materials Testing ; Mesenchymal Stromal Cells - cytology ; Porosity ; Surface Properties ; Tissue Scaffolds - chemistry ; Zirconium</subject><ispartof>Journal of biomedical materials research. 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Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>Al(2) O(3) substrates with controlled porosity were manufactured from nanosized powders obtained by plasma processing. It was observed that when increasing the sintering temperature the overall porosity was decreasing, but the pores got larger. In a second step, Ce stabilized ZrO(2) doped hydroxyapatite coatings were pulsed laser deposited onto the Al(2) O(3) substrates. It was shown that the surface morphology, consisting of aggregates and particulates in micrometric range, was altered by the substrate porosity and interface properties, respectively. TEM studies evidenced that Ce stabilized ZrO(2) doped HA particulates ranged from 10 to 50 nm, strongly depending on the Al(2) O(3) porosity. The coatings consisted of HA nanocrystals embedded in an amorphous matrix quite similar to the bone structure. These findings were congruent with the increased biocompatibility and bioactivity of these layers confirmed by enhanced growing and proliferation of human mesenchymal stem cells.</description><subject>Aluminum Oxide</subject><subject>Cell Proliferation</subject><subject>Cerium</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Durapatite</subject><subject>Humans</subject><subject>Materials Testing</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Porosity</subject><subject>Surface Properties</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Zirconium</subject><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kD1PwzAQhi0kREthYkfeaIcUf8SNM5YKKFKlDjCxRP64FldJHGIHqfwH_jOJKNPdq_e5ZziEbiiZU0LY_UFXcz3nNBPiDI2pECxJc0lH6DKEQw8siOAXaMQoo0QQMkY_D84bXzUqOu1KF49Y1RZr55WJ7mvIUH-o2kAFdcR-h1eAQ1QD-w0Wv7fbKZth65s-rJfY-F5U7wPWx36vY-vLsm8a3_owyEzv2sPgWZbD4XbKZzh0OsRWRQhX6HynygDXpzlBr0-Pb6t1stk-v6yWm6QRgiSMGZnrnKXWqB1hnEqdscxybbJUUWCWpsCpslZaKrihGUgrM8m1yhd5qvgE3f1Zm9Z_dhBiUblgoCxVDb4LhWRM5jlJSU_enshOV2CLpnWVao_F___4L6XhcEI</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Sima, Felix</creator><creator>Ristoscu, Carmen</creator><creator>Caiteanu, Diana</creator><creator>Mihailescu, Cristian N</creator><creator>Stefan, Nicolaie</creator><creator>Mihailescu, Ion N</creator><creator>Prodan, Gabriel</creator><creator>Ciupina, Victor</creator><creator>Palcevskis, Eriks</creator><creator>Krastins, Janis</creator><creator>Sima, Livia E</creator><creator>Petrescu, Stefana M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201102</creationdate><title>Biocompatibility and bioactivity enhancement of Ce stabilized ZrO(2) doped HA coatings by controlled porosity change of Al(2) O(3) substrates</title><author>Sima, Felix ; Ristoscu, Carmen ; Caiteanu, Diana ; Mihailescu, Cristian N ; Stefan, Nicolaie ; Mihailescu, Ion N ; Prodan, Gabriel ; Ciupina, Victor ; Palcevskis, Eriks ; Krastins, Janis ; Sima, Livia E ; Petrescu, Stefana M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p550-22c89b924dcaf02318b727d3bc74a1e2d14e31add8d153c17e8d8783ba9694a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aluminum Oxide</topic><topic>Cell Proliferation</topic><topic>Cerium</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Durapatite</topic><topic>Humans</topic><topic>Materials Testing</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Porosity</topic><topic>Surface Properties</topic><topic>Tissue Scaffolds - chemistry</topic><topic>Zirconium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sima, Felix</creatorcontrib><creatorcontrib>Ristoscu, Carmen</creatorcontrib><creatorcontrib>Caiteanu, Diana</creatorcontrib><creatorcontrib>Mihailescu, Cristian N</creatorcontrib><creatorcontrib>Stefan, Nicolaie</creatorcontrib><creatorcontrib>Mihailescu, Ion N</creatorcontrib><creatorcontrib>Prodan, Gabriel</creatorcontrib><creatorcontrib>Ciupina, Victor</creatorcontrib><creatorcontrib>Palcevskis, Eriks</creatorcontrib><creatorcontrib>Krastins, Janis</creatorcontrib><creatorcontrib>Sima, Livia E</creatorcontrib><creatorcontrib>Petrescu, Stefana M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. 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Part B, Applied biomaterials</jtitle><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><date>2011-02</date><risdate>2011</risdate><volume>96</volume><issue>2</issue><spage>218</spage><epage>224</epage><pages>218-224</pages><eissn>1552-4981</eissn><abstract>Al(2) O(3) substrates with controlled porosity were manufactured from nanosized powders obtained by plasma processing. It was observed that when increasing the sintering temperature the overall porosity was decreasing, but the pores got larger. In a second step, Ce stabilized ZrO(2) doped hydroxyapatite coatings were pulsed laser deposited onto the Al(2) O(3) substrates. It was shown that the surface morphology, consisting of aggregates and particulates in micrometric range, was altered by the substrate porosity and interface properties, respectively. TEM studies evidenced that Ce stabilized ZrO(2) doped HA particulates ranged from 10 to 50 nm, strongly depending on the Al(2) O(3) porosity. 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| identifier | EISSN: 1552-4981 |
| ispartof | Journal of biomedical materials research. Part B, Applied biomaterials, 2011-02, Vol.96 (2), p.218-224 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aluminum Oxide Cell Proliferation Cerium Coated Materials, Biocompatible - chemistry Durapatite Humans Materials Testing Mesenchymal Stromal Cells - cytology Porosity Surface Properties Tissue Scaffolds - chemistry Zirconium |
| title | Biocompatibility and bioactivity enhancement of Ce stabilized ZrO(2) doped HA coatings by controlled porosity change of Al(2) O(3) substrates |
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