The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis
1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that...
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| Veröffentlicht in: | British journal of nutrition 1974-03, Vol.31 (2), p.113-124 |
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| container_title | British journal of nutrition |
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| creator | Fraser, H. S. Alleyne, G. A. O. |
| description | 1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth. 3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein. 4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls. 5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis. |
| doi_str_mv | 10.1079/BJN19740017 |
| format | Article |
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Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN19740017</identifier><identifier>PMID: 4206858</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acid-Base Equilibrium ; Acidosis - metabolism ; Age Factors ; Ammonia - urine ; Animals ; Body Weight ; DNA - analysis ; Energy Metabolism ; General Nutrition ; Gluconeogenesis ; human nutrition ; Hydrogen-Ion Concentration ; Hypertrophy ; Kidney - analysis ; Kidney - growth & development ; Kidney - metabolism ; Nutrition Disorders - metabolism ; Organ Size ; Protein-Energy Malnutrition ; Proteins - analysis ; Rats ; RNA - analysis ; Water - analysis</subject><ispartof>British journal of nutrition, 1974-03, Vol.31 (2), p.113-124</ispartof><rights>Copyright © The Nutrition Society 1974</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-a25ff96eb1453c920c0cd5756884b813fbddf0c4cf43f8d9ed170d3659e89dac3</citedby><cites>FETCH-LOGICAL-c421t-a25ff96eb1453c920c0cd5756884b813fbddf0c4cf43f8d9ed170d3659e89dac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4206858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fraser, H. S.</creatorcontrib><creatorcontrib>Alleyne, G. A. O.</creatorcontrib><title>The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth. 3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein. 4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls. 5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.</description><subject>Acid-Base Equilibrium</subject><subject>Acidosis - metabolism</subject><subject>Age Factors</subject><subject>Ammonia - urine</subject><subject>Animals</subject><subject>Body Weight</subject><subject>DNA - analysis</subject><subject>Energy Metabolism</subject><subject>General Nutrition</subject><subject>Gluconeogenesis</subject><subject>human nutrition</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypertrophy</subject><subject>Kidney - analysis</subject><subject>Kidney - growth & development</subject><subject>Kidney - metabolism</subject><subject>Nutrition Disorders - metabolism</subject><subject>Organ Size</subject><subject>Protein-Energy Malnutrition</subject><subject>Proteins - analysis</subject><subject>Rats</subject><subject>RNA - analysis</subject><subject>Water - analysis</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1rFDEYh4Moda2ePIs5eZHRJJPPoxZblaKI23PI5GM37cxkm2TQ_vemzFI9CCHhzfPw4-UHwEuM3mEk1PuPX79hJShCWDwCG0wF6wjn5DHYIIREhzFlT8GzUq7bKDFSJ-CEEsQlkxuw3-499CF4W2EKcDLjvNQca0wzbKc2ejC1-jzf411Ov-oexhVkU-FNdLO_g2Z265efzdjuckhz8bAmaGx0qcTyHDwJZiz-xfE9BVfnn7Znn7vL7xdfzj5cdpYSXDtDWAiK-6Et3VtFkEXWMcG4lHSQuA-DcwFZagPtg3TKOyyQ6zlTXipnbH8K3qy5h5xuF1-qnmKxfhzN7NNStCREUKpkE9-uos2plOyDPuQ4mXynMdL3vep_em32q2PsMkzePbjHIhvvVh5L9b8fsMk3moteMM0vfmjKGD7nTOht81-vfjBJm12ORV_9JAj3qMcUY0H_JlozDTm6ndfXacmt3_LfDf8ACGuZdA</recordid><startdate>197403</startdate><enddate>197403</enddate><creator>Fraser, H. 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S.</creatorcontrib><creatorcontrib>Alleyne, G. A. O.</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fraser, H. S.</au><au>Alleyne, G. A. O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1974-03</date><risdate>1974</risdate><volume>31</volume><issue>2</issue><spage>113</spage><epage>124</epage><pages>113-124</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth. 3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein. 4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls. 5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>4206858</pmid><doi>10.1079/BJN19740017</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 1974-03, Vol.31 (2), p.113-124 |
| issn | 0007-1145 1475-2662 |
| language | eng |
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| subjects | Acid-Base Equilibrium Acidosis - metabolism Age Factors Ammonia - urine Animals Body Weight DNA - analysis Energy Metabolism General Nutrition Gluconeogenesis human nutrition Hydrogen-Ion Concentration Hypertrophy Kidney - analysis Kidney - growth & development Kidney - metabolism Nutrition Disorders - metabolism Organ Size Protein-Energy Malnutrition Proteins - analysis Rats RNA - analysis Water - analysis |
| title | The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis |
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