Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2

Lysyl oxidase-like protein-2 (LOXL2) induces epithelial to mesenchymal transition and promotes invasiveness. To understand the mechanisms involved, we examined the effect of LOXL2 overexpression in MCF-7 cells on gene expression. We found that LOXL2 up-regulated the expression of receptor activity m...

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Veröffentlicht in:	The FASEB journal 2011-01, Vol.25 (1), p.55-65
Hauptverfasser:	Brekhman, Vera, Lugassie, Jennie, Zaffryar-Eilot, Shelly, Sabo, Edmond, Kessler, Ofra, Smith, Victoria, Golding, Hana, Neufeld, Gera
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - genetics Amino Acid Oxidoreductases - metabolism Animals Cell Line, Tumor Female Gene Expression Profiling Gene Expression Regulation, Neoplastic HCT116 Cells Humans invasion LOXL2 Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oligonucleotide Array Sequence Analysis Protein Binding RAMP3 Receptor Activity-Modifying Protein 3 - genetics Receptor Activity-Modifying Protein 3 - metabolism Receptors, Adrenomedullin - genetics Receptors, Adrenomedullin - metabolism Receptors, Islet Amyloid Polypeptide - genetics Receptors, Islet Amyloid Polypeptide - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference tumor progression Xenograft Model Antitumor Assays
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