Cyclic AMP Content and Histamine Release in Rat Mast Cells

The relationship between the content of cyclic AMP (cAMP) in rat mast cells in vitro and release of histamine was studied with compound 48/80 and a variety of hormones and drugs that affect cAMP in tissues. Papaverine (0.1 mM) increased cAMP in mast cells 3-fold. No increases in cAMP were observed i...

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Veröffentlicht in:	The Journal of immunology (1950) 1974-02, Vol.112 (2), p.511-519
Hauptverfasser:	Johnson, Alice R, Moran, Neil C, Mayer, Steven E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - biosynthesis Angiotensin II - pharmacology Animals Bradykinin - pharmacology Cell Separation Cyclic AMP - analysis DNA - analysis Enzyme Activation Glucagon - pharmacology Histamine Release Isoproterenol - pharmacology Male Mast Cells - analysis Mast Cells - immunology p-Methoxy-N-methylphenethylamine - pharmacology Papaverine - pharmacology Phosphoric Diester Hydrolases - metabolism Prostaglandins - pharmacology Protein Kinases - metabolism Rats Tissue Extracts Trichloroacetic Acid Vasopressins - pharmacology
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