Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices: The influence of agitation sequence

In this article, the influence of agitation in descending and ascending sequences as a systematic method development process for potentially discriminating fed and fasted states and evaluation of its effects on the drug release from swelling gel-forming hydrophilic matrix tablets were investigated....

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2010-12, Vol.81 (2), p.452-460
Hauptverfasser:	Asare-Addo, Kofi, Levina, Marina, Rajabi-Siahboomi, Ali R., Nokhodchi, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Agitation Agitation rate Apparatus III Bio-Dis Dissolution Dissolution testing Drug release mechanism Drugs Extended release HPMC matrix tablets Hydrogen-Ion Concentration Hypromellose Derivatives Kinetics Mathematical analysis Matrices Matrix methods Methylcellulose - analogs & derivatives Methylcellulose - chemistry Solubility Tablets Time Factors
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