RESPONSE IN MACROMOLECULAR SYNTHESES OF MOUSE L CELLS TO BLEOMYCIN, WITH SPECIAL REFERENCE TO CELL-ANTIBIOTIC INTERACTION

The inhibitory effect of bleomycin on DNA, RNA and protein syntheses of mouse L cells was determined. DNA synthesis was most affected. Protein and RNA syntheses were less affected in this order. Inhibition of DNA synthesis exhibited an upward-concave curve as a function of time of exposure to bleomy...

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Veröffentlicht in:	Journal of antibiotics 1973/08/25, Vol.26(8), pp.417-423
Hauptverfasser:	WATANABE, MICHINORI, TAKABE, YOSINOBU, KATSUMATA, TAKESI, TERASIMA, TOYOZO, UMEZAWA, HAMAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Bleomycin - pharmacology Carbon Radioisotopes Depression, Chemical DNA - biosynthesis DNA Repair Drug Resistance L Cells (Cell Line) - drug effects L Cells (Cell Line) - metabolism Leucine - metabolism Mice Protein Biosynthesis RNA - biosynthesis Thymidine - metabolism Time Factors Tritium Uridine - metabolism
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