Influence of interferon on virus particle formation in different oncornavirus carrier cell lines
Three types of oncornavirus‐carrying mouse cell lines were studied. Replication of endogenous sarcoma or leukemia viruses in cell lines producing the infectious viruses was as sensitive to inter feron as that of exogenous vesicular stomatitis virus (VSV). Replication of non‐infectious C‐type virus i...
Gespeichert in:
| Veröffentlicht in: | International journal of cancer 1973-11, Vol.12 (3), p.646-653 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 653 |
|---|---|
| container_issue | 3 |
| container_start_page | 646 |
| container_title | International journal of cancer |
| container_volume | 12 |
| creator | Billiau, A. Sobis, H. De Somer, P. |
| description | Three types of oncornavirus‐carrying mouse cell lines were studied. Replication of endogenous sarcoma or leukemia viruses in cell lines producing the infectious viruses was as sensitive to inter feron as that of exogenous vesicular stomatitis virus (VSV). Replication of non‐infectious C‐type virus in S+L− cells which carry a rescuable Moloney sarcoma virus (MSV) genome did not respond to interferon. However, this cell line was also found to be 70 times less responsive to interferon when tested by an exogenous VSV challenge. Finally, after exposure to interferon, M04 cells, which carry a rescuable MSV genome and produce non‐infectious A‐type particles, developed normal resistance to VSV. Yet, high doses of interferon could not prevent the induction of surplus A‐type particles by bromodeoxyuridine (BDU) and dimethylsulfoxide (DMSO). The results are interpreted as indicating that non‐infectious A‐type particles are synthetized by a mechanism different from that by which infectious C‐type particles are generated. |
| doi_str_mv | 10.1002/ijc.2910120313 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_82240799</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>82240799</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3403-2510d19d3d3696d1f4667f9ae0f5513fcaac4e60ec7d48f4f617a6c55694a0ea3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMotVav3oScvG2dbLLZ5ijFj0rBi57XmJ1Aym62JrtK_70pW9SbMDCH95mX4SHkksGcAeQ3bmPmuWLAcuCMH5EpA1VmkLPimEwTAFnJuDwlZzFuABgrQEzIRHApSiWn5G3lbTOgN0g7S53vMVgMnadpPl0YIt3q0DvTILVdaHXvUuA8rZ1NHPo-gaYLXo-w0SE4DNRg09DGeYzn5MTqJuLFYc_I6_3dy_IxWz8_rJa368xwATzLCwY1UzWvuVSyZlZIWVqlEWxRMG6N1kagBDRlLRZWWMlKLU1RSCU0oOYzcj32bkP3MWDsq9bF_RvaYzfEapHnAkqlEjgfQRO6GAPaahtcq8OuYlDtlVZJafWrNB1cHZqH9xbrH_zgMOVqzL9cg7t_2qrV0_JP9zf_lIPF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>82240799</pqid></control><display><type>article</type><title>Influence of interferon on virus particle formation in different oncornavirus carrier cell lines</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Billiau, A. ; Sobis, H. ; De Somer, P.</creator><creatorcontrib>Billiau, A. ; Sobis, H. ; De Somer, P.</creatorcontrib><description>Three types of oncornavirus‐carrying mouse cell lines were studied. Replication of endogenous sarcoma or leukemia viruses in cell lines producing the infectious viruses was as sensitive to inter feron as that of exogenous vesicular stomatitis virus (VSV). Replication of non‐infectious C‐type virus in S+L− cells which carry a rescuable Moloney sarcoma virus (MSV) genome did not respond to interferon. However, this cell line was also found to be 70 times less responsive to interferon when tested by an exogenous VSV challenge. Finally, after exposure to interferon, M04 cells, which carry a rescuable MSV genome and produce non‐infectious A‐type particles, developed normal resistance to VSV. Yet, high doses of interferon could not prevent the induction of surplus A‐type particles by bromodeoxyuridine (BDU) and dimethylsulfoxide (DMSO). The results are interpreted as indicating that non‐infectious A‐type particles are synthetized by a mechanism different from that by which infectious C‐type particles are generated.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.2910120313</identifier><identifier>PMID: 4364796</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Bromodeoxyuridine - pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic ; Cells, Cultured ; Depression, Chemical ; Dimethyl Sulfoxide - pharmacology ; Dose-Response Relationship, Drug ; Gammaretrovirus - drug effects ; Interferons - administration & dosage ; Interferons - pharmacology ; Leukemia Virus, Murine - drug effects ; Mice ; Microscopy, Electron ; Retroviridae ; Tritium ; Vesicular stomatitis Indiana virus ; Virus Replication - drug effects</subject><ispartof>International journal of cancer, 1973-11, Vol.12 (3), p.646-653</ispartof><rights>Copyright © 1973 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3403-2510d19d3d3696d1f4667f9ae0f5513fcaac4e60ec7d48f4f617a6c55694a0ea3</citedby><cites>FETCH-LOGICAL-c3403-2510d19d3d3696d1f4667f9ae0f5513fcaac4e60ec7d48f4f617a6c55694a0ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.2910120313$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.2910120313$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4364796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Billiau, A.</creatorcontrib><creatorcontrib>Sobis, H.</creatorcontrib><creatorcontrib>De Somer, P.</creatorcontrib><title>Influence of interferon on virus particle formation in different oncornavirus carrier cell lines</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Three types of oncornavirus‐carrying mouse cell lines were studied. Replication of endogenous sarcoma or leukemia viruses in cell lines producing the infectious viruses was as sensitive to inter feron as that of exogenous vesicular stomatitis virus (VSV). Replication of non‐infectious C‐type virus in S+L− cells which carry a rescuable Moloney sarcoma virus (MSV) genome did not respond to interferon. However, this cell line was also found to be 70 times less responsive to interferon when tested by an exogenous VSV challenge. Finally, after exposure to interferon, M04 cells, which carry a rescuable MSV genome and produce non‐infectious A‐type particles, developed normal resistance to VSV. Yet, high doses of interferon could not prevent the induction of surplus A‐type particles by bromodeoxyuridine (BDU) and dimethylsulfoxide (DMSO). The results are interpreted as indicating that non‐infectious A‐type particles are synthetized by a mechanism different from that by which infectious C‐type particles are generated.</description><subject>Animals</subject><subject>Bromodeoxyuridine - pharmacology</subject><subject>Carrier Proteins</subject><subject>Cell Line</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cells, Cultured</subject><subject>Depression, Chemical</subject><subject>Dimethyl Sulfoxide - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gammaretrovirus - drug effects</subject><subject>Interferons - administration & dosage</subject><subject>Interferons - pharmacology</subject><subject>Leukemia Virus, Murine - drug effects</subject><subject>Mice</subject><subject>Microscopy, Electron</subject><subject>Retroviridae</subject><subject>Tritium</subject><subject>Vesicular stomatitis Indiana virus</subject><subject>Virus Replication - drug effects</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVav3oScvG2dbLLZ5ijFj0rBi57XmJ1Aym62JrtK_70pW9SbMDCH95mX4SHkksGcAeQ3bmPmuWLAcuCMH5EpA1VmkLPimEwTAFnJuDwlZzFuABgrQEzIRHApSiWn5G3lbTOgN0g7S53vMVgMnadpPl0YIt3q0DvTILVdaHXvUuA8rZ1NHPo-gaYLXo-w0SE4DNRg09DGeYzn5MTqJuLFYc_I6_3dy_IxWz8_rJa368xwATzLCwY1UzWvuVSyZlZIWVqlEWxRMG6N1kagBDRlLRZWWMlKLU1RSCU0oOYzcj32bkP3MWDsq9bF_RvaYzfEapHnAkqlEjgfQRO6GAPaahtcq8OuYlDtlVZJafWrNB1cHZqH9xbrH_zgMOVqzL9cg7t_2qrV0_JP9zf_lIPF</recordid><startdate>19731115</startdate><enddate>19731115</enddate><creator>Billiau, A.</creator><creator>Sobis, H.</creator><creator>De Somer, P.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19731115</creationdate><title>Influence of interferon on virus particle formation in different oncornavirus carrier cell lines</title><author>Billiau, A. ; Sobis, H. ; De Somer, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3403-2510d19d3d3696d1f4667f9ae0f5513fcaac4e60ec7d48f4f617a6c55694a0ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Bromodeoxyuridine - pharmacology</topic><topic>Carrier Proteins</topic><topic>Cell Line</topic><topic>Cell Transformation, Neoplastic</topic><topic>Cells, Cultured</topic><topic>Depression, Chemical</topic><topic>Dimethyl Sulfoxide - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gammaretrovirus - drug effects</topic><topic>Interferons - administration & dosage</topic><topic>Interferons - pharmacology</topic><topic>Leukemia Virus, Murine - drug effects</topic><topic>Mice</topic><topic>Microscopy, Electron</topic><topic>Retroviridae</topic><topic>Tritium</topic><topic>Vesicular stomatitis Indiana virus</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Billiau, A.</creatorcontrib><creatorcontrib>Sobis, H.</creatorcontrib><creatorcontrib>De Somer, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Billiau, A.</au><au>Sobis, H.</au><au>De Somer, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of interferon on virus particle formation in different oncornavirus carrier cell lines</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1973-11-15</date><risdate>1973</risdate><volume>12</volume><issue>3</issue><spage>646</spage><epage>653</epage><pages>646-653</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>Three types of oncornavirus‐carrying mouse cell lines were studied. Replication of endogenous sarcoma or leukemia viruses in cell lines producing the infectious viruses was as sensitive to inter feron as that of exogenous vesicular stomatitis virus (VSV). Replication of non‐infectious C‐type virus in S+L− cells which carry a rescuable Moloney sarcoma virus (MSV) genome did not respond to interferon. However, this cell line was also found to be 70 times less responsive to interferon when tested by an exogenous VSV challenge. Finally, after exposure to interferon, M04 cells, which carry a rescuable MSV genome and produce non‐infectious A‐type particles, developed normal resistance to VSV. Yet, high doses of interferon could not prevent the induction of surplus A‐type particles by bromodeoxyuridine (BDU) and dimethylsulfoxide (DMSO). The results are interpreted as indicating that non‐infectious A‐type particles are synthetized by a mechanism different from that by which infectious C‐type particles are generated.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4364796</pmid><doi>10.1002/ijc.2910120313</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 1973-11, Vol.12 (3), p.646-653 |
| issn | 0020-7136 1097-0215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82240799 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Bromodeoxyuridine - pharmacology Carrier Proteins Cell Line Cell Transformation, Neoplastic Cells, Cultured Depression, Chemical Dimethyl Sulfoxide - pharmacology Dose-Response Relationship, Drug Gammaretrovirus - drug effects Interferons - administration & dosage Interferons - pharmacology Leukemia Virus, Murine - drug effects Mice Microscopy, Electron Retroviridae Tritium Vesicular stomatitis Indiana virus Virus Replication - drug effects |
| title | Influence of interferon on virus particle formation in different oncornavirus carrier cell lines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T22%3A17%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20interferon%20on%20virus%20particle%20formation%20in%20different%20oncornavirus%20carrier%20cell%20lines&rft.jtitle=International%20journal%20of%20cancer&rft.au=Billiau,%20A.&rft.date=1973-11-15&rft.volume=12&rft.issue=3&rft.spage=646&rft.epage=653&rft.pages=646-653&rft.issn=0020-7136&rft.eissn=1097-0215&rft_id=info:doi/10.1002/ijc.2910120313&rft_dat=%3Cproquest_cross%3E82240799%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=82240799&rft_id=info:pmid/4364796&rfr_iscdi=true |