Tranquilizing and Antiserotonin Activity of Nicotinamide

Tranquilizing and Antiserotonin Activity of Nicotinamide

Nicotinamide in large amounts antagonized the action of serotonin on smooth muscles in vitro and in vivo. It also tranquilized animals. The antagonism differed in some respects from that of an antimetabolite of serotonin.

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1958-11, Vol.128 (3334), p.1277-1278
1. Verfasser: Woolley, D. W.
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Animals
Antihypertensive Agents
Antimetabolites
Hormones
Hypnotics and Sedatives
Hypothermia
Mental illness
Muscle, Smooth
Muscles
Muscles - drug effects
Niacin - analogs & derivatives
Niacinamide
Nicotinic antagonists
Old Medline
Sedatives
Serotonin
Serotonin Antagonists
Tranquilizing Agents
Uterus
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Beschreibung
Zusammenfassung:Nicotinamide in large amounts antagonized the action of serotonin on smooth muscles in vitro and in vivo. It also tranquilized animals. The antagonism differed in some respects from that of an antimetabolite of serotonin.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.128.3334.1277