Idiopathic Pulmonary Hemosiderosis: An Electron Microscopic and Immunofluorescent Study
Electron microscopic and immunofluorescent studies are reported in a patient with idiopathic pulmonary hemosiderosis, suggesting that idiopathic pulmonary hemosiderosis is distinct from other pulmonary hemorrhagic syndromes associated with antibasement membrane antibody or immune complex mediated di...
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| Veröffentlicht in: | Chest 1974-01, Vol.65 (1), p.41-45 |
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| container_title | Chest |
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| creator | Irwin, R S Cottrell, T S Hsu, K C Griswold, W R Thomas, 3rd, H M |
| description | Electron microscopic and immunofluorescent studies are reported in a patient with idiopathic pulmonary hemosiderosis, suggesting
that idiopathic pulmonary hemosiderosis is distinct from other pulmonary hemorrhagic syndromes associated with antibasement
membrane antibody or immune complex mediated diseases. The ultrastructural studies showed evidence of nonspecific lung injury
and indirect evidence of vascular lesions. No subendothelial deposits or basement membrane lesions were seen. Immunofluorescent
studies failed to reveal any evidence for localization of IgG, IgM, βIC, Clq or fibrinogen in the lung. Investigation of platelet
function showed low and low normal values of platelet retention on a glass bead column, but findings were otherwise normal. |
| doi_str_mv | 10.1378/chest.65.1.41 |
| format | Article |
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that idiopathic pulmonary hemosiderosis is distinct from other pulmonary hemorrhagic syndromes associated with antibasement
membrane antibody or immune complex mediated diseases. The ultrastructural studies showed evidence of nonspecific lung injury
and indirect evidence of vascular lesions. No subendothelial deposits or basement membrane lesions were seen. Immunofluorescent
studies failed to reveal any evidence for localization of IgG, IgM, βIC, Clq or fibrinogen in the lung. Investigation of platelet
function showed low and low normal values of platelet retention on a glass bead column, but findings were otherwise normal.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.65.1.41</identifier><identifier>PMID: 4588311</identifier><language>eng</language><publisher>United States: American College of Chest Physicians</publisher><subject>Adult ; Basement Membrane - anatomy & histology ; Biopsy ; Collagen ; Cytoplasm ; Diagnosis, Differential ; Epithelial Cells ; Erythrocytes ; Fibrin ; Fluorescent Antibody Technique ; Glycogen ; Hemorrhage - pathology ; Hemosiderin ; Hemosiderosis - diagnosis ; Hemosiderosis - immunology ; Hemosiderosis - pathology ; Humans ; Leukocytes ; Lung - pathology ; Lung Diseases - diagnosis ; Lung Diseases - immunology ; Lung Diseases - pathology ; Macrophages ; Male ; Microscopy, Electron ; Pulmonary Alveoli - pathology ; Pulmonary Edema - pathology</subject><ispartof>Chest, 1974-01, Vol.65 (1), p.41-45</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4588311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irwin, R S</creatorcontrib><creatorcontrib>Cottrell, T S</creatorcontrib><creatorcontrib>Hsu, K C</creatorcontrib><creatorcontrib>Griswold, W R</creatorcontrib><creatorcontrib>Thomas, 3rd, H M</creatorcontrib><title>Idiopathic Pulmonary Hemosiderosis: An Electron Microscopic and Immunofluorescent Study</title><title>Chest</title><addtitle>Chest</addtitle><description>Electron microscopic and immunofluorescent studies are reported in a patient with idiopathic pulmonary hemosiderosis, suggesting
that idiopathic pulmonary hemosiderosis is distinct from other pulmonary hemorrhagic syndromes associated with antibasement
membrane antibody or immune complex mediated diseases. The ultrastructural studies showed evidence of nonspecific lung injury
and indirect evidence of vascular lesions. No subendothelial deposits or basement membrane lesions were seen. Immunofluorescent
studies failed to reveal any evidence for localization of IgG, IgM, βIC, Clq or fibrinogen in the lung. Investigation of platelet
function showed low and low normal values of platelet retention on a glass bead column, but findings were otherwise normal.</description><subject>Adult</subject><subject>Basement Membrane - anatomy & histology</subject><subject>Biopsy</subject><subject>Collagen</subject><subject>Cytoplasm</subject><subject>Diagnosis, Differential</subject><subject>Epithelial Cells</subject><subject>Erythrocytes</subject><subject>Fibrin</subject><subject>Fluorescent Antibody Technique</subject><subject>Glycogen</subject><subject>Hemorrhage - pathology</subject><subject>Hemosiderin</subject><subject>Hemosiderosis - diagnosis</subject><subject>Hemosiderosis - immunology</subject><subject>Hemosiderosis - pathology</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Lung - pathology</subject><subject>Lung Diseases - diagnosis</subject><subject>Lung Diseases - immunology</subject><subject>Lung Diseases - pathology</subject><subject>Macrophages</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Pulmonary Alveoli - pathology</subject><subject>Pulmonary Edema - pathology</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkE1PwzAMhiMEGmNw5IjUE7eWOmnalNuEBps0BBIgjlXaJLRTPkrTCu3fE9gutuz3sWW_CF1DmgAp2F3TSj8mOU0gyeAEzaEkEBOakVM0T1PAMclLfI4uvN-loYYyn6FZRhkjAHP0uRGd6_nYdk30OmnjLB_20Voa5zshhxD9fbS00UrLZhycjZ67JnQb14cBbkW0MWayTunJDdI30o7R2ziJ_SU6U1x7eXXMC_TxuHp_WMfbl6fNw3IbtzjLxlhxWtJCECVqnNdMYSCgoMlrXJY0TTOG_yRGcV0UAHVRF1I0SjHCVCpBMLJAt4e9_eC-p-BEZbpwhtbcSjf5imFgJZA8gDdHcKqNFFU_dCa8Wh2dCHp80Nvuq_3pBll5w7UONKn-Ld65abBc57SCKgPyC2SUchs</recordid><startdate>19740101</startdate><enddate>19740101</enddate><creator>Irwin, R S</creator><creator>Cottrell, T S</creator><creator>Hsu, K C</creator><creator>Griswold, W R</creator><creator>Thomas, 3rd, H M</creator><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19740101</creationdate><title>Idiopathic Pulmonary Hemosiderosis: An Electron Microscopic and Immunofluorescent Study</title><author>Irwin, R S ; Cottrell, T S ; Hsu, K C ; Griswold, W R ; Thomas, 3rd, H M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h244t-fa5957d3fdb26b8f2131f1c6b2995004823fdb852b7711b7b7edcff838f0e1d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adult</topic><topic>Basement Membrane - anatomy & histology</topic><topic>Biopsy</topic><topic>Collagen</topic><topic>Cytoplasm</topic><topic>Diagnosis, Differential</topic><topic>Epithelial Cells</topic><topic>Erythrocytes</topic><topic>Fibrin</topic><topic>Fluorescent Antibody Technique</topic><topic>Glycogen</topic><topic>Hemorrhage - pathology</topic><topic>Hemosiderin</topic><topic>Hemosiderosis - diagnosis</topic><topic>Hemosiderosis - immunology</topic><topic>Hemosiderosis - pathology</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Lung - pathology</topic><topic>Lung Diseases - diagnosis</topic><topic>Lung Diseases - immunology</topic><topic>Lung Diseases - pathology</topic><topic>Macrophages</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Pulmonary Alveoli - pathology</topic><topic>Pulmonary Edema - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irwin, R S</creatorcontrib><creatorcontrib>Cottrell, T S</creatorcontrib><creatorcontrib>Hsu, K C</creatorcontrib><creatorcontrib>Griswold, W R</creatorcontrib><creatorcontrib>Thomas, 3rd, H M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irwin, R S</au><au>Cottrell, T S</au><au>Hsu, K C</au><au>Griswold, W R</au><au>Thomas, 3rd, H M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Idiopathic Pulmonary Hemosiderosis: An Electron Microscopic and Immunofluorescent Study</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1974-01-01</date><risdate>1974</risdate><volume>65</volume><issue>1</issue><spage>41</spage><epage>45</epage><pages>41-45</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><abstract>Electron microscopic and immunofluorescent studies are reported in a patient with idiopathic pulmonary hemosiderosis, suggesting
that idiopathic pulmonary hemosiderosis is distinct from other pulmonary hemorrhagic syndromes associated with antibasement
membrane antibody or immune complex mediated diseases. The ultrastructural studies showed evidence of nonspecific lung injury
and indirect evidence of vascular lesions. No subendothelial deposits or basement membrane lesions were seen. Immunofluorescent
studies failed to reveal any evidence for localization of IgG, IgM, βIC, Clq or fibrinogen in the lung. Investigation of platelet
function showed low and low normal values of platelet retention on a glass bead column, but findings were otherwise normal.</abstract><cop>United States</cop><pub>American College of Chest Physicians</pub><pmid>4588311</pmid><doi>10.1378/chest.65.1.41</doi><tpages>5</tpages></addata></record> |
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| ispartof | Chest, 1974-01, Vol.65 (1), p.41-45 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82189136 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Basement Membrane - anatomy & histology Biopsy Collagen Cytoplasm Diagnosis, Differential Epithelial Cells Erythrocytes Fibrin Fluorescent Antibody Technique Glycogen Hemorrhage - pathology Hemosiderin Hemosiderosis - diagnosis Hemosiderosis - immunology Hemosiderosis - pathology Humans Leukocytes Lung - pathology Lung Diseases - diagnosis Lung Diseases - immunology Lung Diseases - pathology Macrophages Male Microscopy, Electron Pulmonary Alveoli - pathology Pulmonary Edema - pathology |
| title | Idiopathic Pulmonary Hemosiderosis: An Electron Microscopic and Immunofluorescent Study |
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