Efficacy and Safety of Adjunctive Local Moxifloxacin Delivery in the Treatment of Periodontitis

Background: Moxifloxacin exerts excellent antibacterial activity against most putative periodontal pathogens and has been shown to kill bacteria in biofilm and host cells. Methods: Patients with chronic periodontitis were randomly assigned to receive a single subgingival application of a 0.125%, 0.4...

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Veröffentlicht in:	Journal of periodontology (1970) 2011-01, Vol.82 (1), p.96-105
Hauptverfasser:	Flemmig, Thomas F., Petersilka, Gregor, Völp, Andreas, Gravemeier, Martina, Zilly, Martin, Mross, Daniela, Prior, Karola, Yamamoto, Julie, Beikler, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adult Aged Aggregatibacter actinomycetemcomitans - drug effects Anti-Infective Agents - administration & dosage Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Anti‐bacterial agents Aza Compounds - administration & dosage Bacterial Load Bacteroides - drug effects biofilms Biological and medical sciences Chronic Periodontitis - drug therapy Chronic Periodontitis - microbiology Chronic Periodontitis - therapy Delivery. Postpartum. Lactation Dental Plaque - microbiology Dental Scaling Dentistry Drug Resistance, Bacterial Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Fluoroquinolones Follow-Up Studies Gingival Hemorrhage - drug therapy Gingival Hemorrhage - therapy Gingival Recession - drug therapy Gingival Recession - therapy Gynecology. Andrology. Obstetrics Humans Male Medical sciences Middle Aged moxifloxacin Non tumoral diseases Otorhinolaryngology. Stomatology Periodontal Attachment Loss - drug therapy Periodontal Attachment Loss - microbiology Periodontal Attachment Loss - therapy periodontal diseases Periodontal Pocket - drug therapy Periodontal Pocket - microbiology Periodontal Pocket - therapy periodontitis Pharmacology. Drug treatments Placebos Porphyromonas gingivalis - drug effects Quinolines - administration & dosage Root Planing Safety Streptococcus intermedius - drug effects Treatment Outcome Treponema denticola - drug effects
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