Short Communication: Contribution of the Immunovirological State and Traditional Cardiovascular Risk Factors to Low HDL-Cholesterol in HIV Patients
The prevalence of low HDL-C levels in an HIV population and its related factors was investigated. We undertook a multicenter, cross-sectional study of all HIV patients on regular follow-up in five hospitals (Southern Spain). A physical examination and fasting laboratory analysis were performed and a...
Gespeichert in:
| Veröffentlicht in: | AIDS research and human retroviruses 2010-11, Vol.26 (11), p.1167-1170 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1170 |
|---|---|
| container_issue | 11 |
| container_start_page | 1167 |
| container_title | AIDS research and human retroviruses |
| container_volume | 26 |
| creator | PALACIOS, R PUERTA, S ORIHUELA, F OLALLA, J ROLDAN, J GRANA, M MARQUEZ, M COLMENERO, J. D CANTOS, J |
| description | The prevalence of low HDL-C levels in an HIV population and its related factors was investigated. We undertook a multicenter, cross-sectional study of all HIV patients on regular follow-up in five hospitals (Southern Spain). A physical examination and fasting laboratory analysis were performed and a questionnaire about cardiovascular risk factors was provided. One thousand and seventy-two patients were included, 43.8% of whom had low HDL-C levels. The prevalence of low HDL-C was higher among patients diagnosed with AIDS, those not on antiretroviral therapy, those with a detectable HIV viral load, those with CD4 cell counts ≤350 cells/μl, smokers, and those with hypertriglyceridemia. For patients on antiretroviral therapy, the prevalence of low HDL-C was higher for those on protease inhibitors than those taking nonnucleoside reverse transcriptase inhibitors. In the multivariate analysis, low HDL-C levels were associated with tobacco use (OR 1.37, 95% CI 1.04-1.8; p = 0.04), hypertriglyceridemia (OR 2.94, 95% CI 2.2-3.8; p |
| doi_str_mv | 10.1089/aid.2009.0284 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_821735991</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A245542773</galeid><sourcerecordid>A245542773</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-f7efa1c83ae0d05c1d88c990022a2bd22dc56dd93ea7f957f263b14c81a0e1163</originalsourceid><addsrcrecordid>eNqF0k1rFDEYB_Agit1Wj14lINLTrHmZ2Um8ldG6CwuKrV6HZ_PSjc4kbZKp-Dn8wmbYVREEySF5wi9PAvkj9IySJSVCvgKnl4wQuSRM1A_QgkpOK1GT5iFaECFkxRiTJ-g0pS-kMMaax-iElYXkki7Qj6t9iBl3YRwn7xRkF_zrUvoc3W6aKxwsznuDN7MI9y6GIdwUOeCrDNlg8BpfR9BuxmW3g6hduIekpgEi_ujSV3wJKoeYcA54G77h9Ztt1e3DYFI2pR12Hq83n_GHcrvxOT1BjywMyTw9zmfo0-Xb625dbd-_23QX20rVjObKtsYCVYKDIZo0imohlJSEMAZspxnTqllpLbmB1sqmtWzFd7RWggIxlK74GTo_9L2N4W4qj-lHl5QZBvAmTKkXjLa8kZL-X9JGrgireZEvDvIGBtM7b0OOoGbdX7C6aWrWtrNa_kOVoc3oVPDGurL_14HqcEDFkFI0tr-NboT4vaekn3PQlxz0cw76OQfFPz8-eNqNRv_Wvz6-gJdHUD4KBhvBK5f-ON5wSqTkPwE_q7th</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>815960243</pqid></control><display><type>article</type><title>Short Communication: Contribution of the Immunovirological State and Traditional Cardiovascular Risk Factors to Low HDL-Cholesterol in HIV Patients</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>PALACIOS, R ; PUERTA, S ; ORIHUELA, F ; OLALLA, J ; ROLDAN, J ; GRANA, M ; MARQUEZ, M ; COLMENERO, J. D ; CANTOS, J</creator><creatorcontrib>PALACIOS, R ; PUERTA, S ; ORIHUELA, F ; OLALLA, J ; ROLDAN, J ; GRANA, M ; MARQUEZ, M ; COLMENERO, J. D ; CANTOS, J ; Sociedad Andaluza de Enfermedades Infecciosas (SAEI)</creatorcontrib><description>The prevalence of low HDL-C levels in an HIV population and its related factors was investigated. We undertook a multicenter, cross-sectional study of all HIV patients on regular follow-up in five hospitals (Southern Spain). A physical examination and fasting laboratory analysis were performed and a questionnaire about cardiovascular risk factors was provided. One thousand and seventy-two patients were included, 43.8% of whom had low HDL-C levels. The prevalence of low HDL-C was higher among patients diagnosed with AIDS, those not on antiretroviral therapy, those with a detectable HIV viral load, those with CD4 cell counts ≤350 cells/μl, smokers, and those with hypertriglyceridemia. For patients on antiretroviral therapy, the prevalence of low HDL-C was higher for those on protease inhibitors than those taking nonnucleoside reverse transcriptase inhibitors. In the multivariate analysis, low HDL-C levels were associated with tobacco use (OR 1.37, 95% CI 1.04-1.8; p = 0.04), hypertriglyceridemia (OR 2.94, 95% CI 2.2-3.8; p < 0.00001), CD4 cells count ≤350 cells/μl (OR 1.74, 95% CI 1.2-2.3; p < 0.0001), and a detectable HIV viral load (OR 1.85, 95% CI 1.3-2.5; p < 0.0001). The immunological and virological conditions, in addition to traditional cardiovascular risk factors such as tobacco use and hypertriglyceridemia, affect HDL-C levels in HIV-infected patients. For patients on antiretroviral therapy, the use of protease inhibitors is associated with a higher probability of low levels of HDL-C. Although it is not clear if the higher HDL-C levels associated with antiretroviral use are surrogates for decreased cardiovascular disease risk, this may be another reason to start antiretroviral therapy earlier.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2009.0284</identifier><identifier>PMID: 20929391</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>New Rochelle, NY: Liebert</publisher><subject>Adult ; AIDS/HIV ; Anti-HIV Agents - therapeutic use ; Antiretroviral Therapy, Highly Active - methods ; Biological and medical sciences ; Cardiovascular diseases ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cholesterol, HDL ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; Diagnosis ; Female ; Health aspects ; HIV Infections - complications ; HIV Infections - epidemiology ; HIV patients ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Physiological aspects ; Prevalence ; Retrovirus ; Risk Factors ; Spain - epidemiology ; Surveys ; Surveys and Questionnaires ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS research and human retroviruses, 2010-11, Vol.26 (11), p.1167-1170</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-f7efa1c83ae0d05c1d88c990022a2bd22dc56dd93ea7f957f263b14c81a0e1163</citedby><cites>FETCH-LOGICAL-c421t-f7efa1c83ae0d05c1d88c990022a2bd22dc56dd93ea7f957f263b14c81a0e1163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3042,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23531099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20929391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PALACIOS, R</creatorcontrib><creatorcontrib>PUERTA, S</creatorcontrib><creatorcontrib>ORIHUELA, F</creatorcontrib><creatorcontrib>OLALLA, J</creatorcontrib><creatorcontrib>ROLDAN, J</creatorcontrib><creatorcontrib>GRANA, M</creatorcontrib><creatorcontrib>MARQUEZ, M</creatorcontrib><creatorcontrib>COLMENERO, J. D</creatorcontrib><creatorcontrib>CANTOS, J</creatorcontrib><creatorcontrib>Sociedad Andaluza de Enfermedades Infecciosas (SAEI)</creatorcontrib><title>Short Communication: Contribution of the Immunovirological State and Traditional Cardiovascular Risk Factors to Low HDL-Cholesterol in HIV Patients</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>The prevalence of low HDL-C levels in an HIV population and its related factors was investigated. We undertook a multicenter, cross-sectional study of all HIV patients on regular follow-up in five hospitals (Southern Spain). A physical examination and fasting laboratory analysis were performed and a questionnaire about cardiovascular risk factors was provided. One thousand and seventy-two patients were included, 43.8% of whom had low HDL-C levels. The prevalence of low HDL-C was higher among patients diagnosed with AIDS, those not on antiretroviral therapy, those with a detectable HIV viral load, those with CD4 cell counts ≤350 cells/μl, smokers, and those with hypertriglyceridemia. For patients on antiretroviral therapy, the prevalence of low HDL-C was higher for those on protease inhibitors than those taking nonnucleoside reverse transcriptase inhibitors. In the multivariate analysis, low HDL-C levels were associated with tobacco use (OR 1.37, 95% CI 1.04-1.8; p = 0.04), hypertriglyceridemia (OR 2.94, 95% CI 2.2-3.8; p < 0.00001), CD4 cells count ≤350 cells/μl (OR 1.74, 95% CI 1.2-2.3; p < 0.0001), and a detectable HIV viral load (OR 1.85, 95% CI 1.3-2.5; p < 0.0001). The immunological and virological conditions, in addition to traditional cardiovascular risk factors such as tobacco use and hypertriglyceridemia, affect HDL-C levels in HIV-infected patients. For patients on antiretroviral therapy, the use of protease inhibitors is associated with a higher probability of low levels of HDL-C. Although it is not clear if the higher HDL-C levels associated with antiretroviral use are surrogates for decreased cardiovascular disease risk, this may be another reason to start antiretroviral therapy earlier.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral Therapy, Highly Active - methods</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cholesterol, HDL</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Health aspects</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>HIV patients</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Physiological aspects</subject><subject>Prevalence</subject><subject>Retrovirus</subject><subject>Risk Factors</subject><subject>Spain - epidemiology</subject><subject>Surveys</subject><subject>Surveys and Questionnaires</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0k1rFDEYB_Agit1Wj14lINLTrHmZ2Um8ldG6CwuKrV6HZ_PSjc4kbZKp-Dn8wmbYVREEySF5wi9PAvkj9IySJSVCvgKnl4wQuSRM1A_QgkpOK1GT5iFaECFkxRiTJ-g0pS-kMMaax-iElYXkki7Qj6t9iBl3YRwn7xRkF_zrUvoc3W6aKxwsznuDN7MI9y6GIdwUOeCrDNlg8BpfR9BuxmW3g6hduIekpgEi_ujSV3wJKoeYcA54G77h9Ztt1e3DYFI2pR12Hq83n_GHcrvxOT1BjywMyTw9zmfo0-Xb625dbd-_23QX20rVjObKtsYCVYKDIZo0imohlJSEMAZspxnTqllpLbmB1sqmtWzFd7RWggIxlK74GTo_9L2N4W4qj-lHl5QZBvAmTKkXjLa8kZL-X9JGrgireZEvDvIGBtM7b0OOoGbdX7C6aWrWtrNa_kOVoc3oVPDGurL_14HqcEDFkFI0tr-NboT4vaekn3PQlxz0cw76OQfFPz8-eNqNRv_Wvz6-gJdHUD4KBhvBK5f-ON5wSqTkPwE_q7th</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>PALACIOS, R</creator><creator>PUERTA, S</creator><creator>ORIHUELA, F</creator><creator>OLALLA, J</creator><creator>ROLDAN, J</creator><creator>GRANA, M</creator><creator>MARQUEZ, M</creator><creator>COLMENERO, J. D</creator><creator>CANTOS, J</creator><general>Liebert</general><general>Mary Ann Liebert, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20101101</creationdate><title>Short Communication: Contribution of the Immunovirological State and Traditional Cardiovascular Risk Factors to Low HDL-Cholesterol in HIV Patients</title><author>PALACIOS, R ; PUERTA, S ; ORIHUELA, F ; OLALLA, J ; ROLDAN, J ; GRANA, M ; MARQUEZ, M ; COLMENERO, J. D ; CANTOS, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-f7efa1c83ae0d05c1d88c990022a2bd22dc56dd93ea7f957f263b14c81a0e1163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiretroviral Therapy, Highly Active - methods</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cholesterol, HDL</topic><topic>Cholesterol, HDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Health aspects</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - epidemiology</topic><topic>HIV patients</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Physiological aspects</topic><topic>Prevalence</topic><topic>Retrovirus</topic><topic>Risk Factors</topic><topic>Spain - epidemiology</topic><topic>Surveys</topic><topic>Surveys and Questionnaires</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PALACIOS, R</creatorcontrib><creatorcontrib>PUERTA, S</creatorcontrib><creatorcontrib>ORIHUELA, F</creatorcontrib><creatorcontrib>OLALLA, J</creatorcontrib><creatorcontrib>ROLDAN, J</creatorcontrib><creatorcontrib>GRANA, M</creatorcontrib><creatorcontrib>MARQUEZ, M</creatorcontrib><creatorcontrib>COLMENERO, J. D</creatorcontrib><creatorcontrib>CANTOS, J</creatorcontrib><creatorcontrib>Sociedad Andaluza de Enfermedades Infecciosas (SAEI)</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PALACIOS, R</au><au>PUERTA, S</au><au>ORIHUELA, F</au><au>OLALLA, J</au><au>ROLDAN, J</au><au>GRANA, M</au><au>MARQUEZ, M</au><au>COLMENERO, J. D</au><au>CANTOS, J</au><aucorp>Sociedad Andaluza de Enfermedades Infecciosas (SAEI)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short Communication: Contribution of the Immunovirological State and Traditional Cardiovascular Risk Factors to Low HDL-Cholesterol in HIV Patients</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>26</volume><issue>11</issue><spage>1167</spage><epage>1170</epage><pages>1167-1170</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>The prevalence of low HDL-C levels in an HIV population and its related factors was investigated. We undertook a multicenter, cross-sectional study of all HIV patients on regular follow-up in five hospitals (Southern Spain). A physical examination and fasting laboratory analysis were performed and a questionnaire about cardiovascular risk factors was provided. One thousand and seventy-two patients were included, 43.8% of whom had low HDL-C levels. The prevalence of low HDL-C was higher among patients diagnosed with AIDS, those not on antiretroviral therapy, those with a detectable HIV viral load, those with CD4 cell counts ≤350 cells/μl, smokers, and those with hypertriglyceridemia. For patients on antiretroviral therapy, the prevalence of low HDL-C was higher for those on protease inhibitors than those taking nonnucleoside reverse transcriptase inhibitors. In the multivariate analysis, low HDL-C levels were associated with tobacco use (OR 1.37, 95% CI 1.04-1.8; p = 0.04), hypertriglyceridemia (OR 2.94, 95% CI 2.2-3.8; p < 0.00001), CD4 cells count ≤350 cells/μl (OR 1.74, 95% CI 1.2-2.3; p < 0.0001), and a detectable HIV viral load (OR 1.85, 95% CI 1.3-2.5; p < 0.0001). The immunological and virological conditions, in addition to traditional cardiovascular risk factors such as tobacco use and hypertriglyceridemia, affect HDL-C levels in HIV-infected patients. For patients on antiretroviral therapy, the use of protease inhibitors is associated with a higher probability of low levels of HDL-C. Although it is not clear if the higher HDL-C levels associated with antiretroviral use are surrogates for decreased cardiovascular disease risk, this may be another reason to start antiretroviral therapy earlier.</abstract><cop>New Rochelle, NY</cop><pub>Liebert</pub><pmid>20929391</pmid><doi>10.1089/aid.2009.0284</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-2229 |
| ispartof | AIDS research and human retroviruses, 2010-11, Vol.26 (11), p.1167-1170 |
| issn | 0889-2229 1931-8405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_821735991 |
| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Adult AIDS/HIV Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active - methods Biological and medical sciences Cardiovascular diseases Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cholesterol, HDL Cholesterol, HDL - blood Cross-Sectional Studies Diagnosis Female Health aspects HIV Infections - complications HIV Infections - epidemiology HIV patients Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Physiological aspects Prevalence Retrovirus Risk Factors Spain - epidemiology Surveys Surveys and Questionnaires Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Short Communication: Contribution of the Immunovirological State and Traditional Cardiovascular Risk Factors to Low HDL-Cholesterol in HIV Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T21%3A47%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Short%20Communication:%20Contribution%20of%20the%20Immunovirological%20State%20and%20Traditional%20Cardiovascular%20Risk%20Factors%20to%20Low%20HDL-Cholesterol%20in%20HIV%20Patients&rft.jtitle=AIDS%20research%20and%20human%20retroviruses&rft.au=PALACIOS,%20R&rft.aucorp=Sociedad%20Andaluza%20de%20Enfermedades%20Infecciosas%20(SAEI)&rft.date=2010-11-01&rft.volume=26&rft.issue=11&rft.spage=1167&rft.epage=1170&rft.pages=1167-1170&rft.issn=0889-2229&rft.eissn=1931-8405&rft.coden=ARHRE7&rft_id=info:doi/10.1089/aid.2009.0284&rft_dat=%3Cgale_proqu%3EA245542773%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=815960243&rft_id=info:pmid/20929391&rft_galeid=A245542773&rfr_iscdi=true |